Integrative gas-based therapeutics for cancer treatment: Recent advances and multi-therapy innovations

Coordination Chemistry Reviews, Год журнала: 2025, Номер 539, С. 216746 - 216746

Опубликована: Май 2, 2025

Язык: Английский

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Liquid metal-based nanocomposite with triple-amplified Fenton-like reaction for tumor chemodynamic/photothermal/immunotherapy

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163326 - 163326

Опубликована: Май 1, 2025

Язык: Английский

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Conjugated Polymer-Photosensitizers for Cancer Photodynamic Therapy and Their Multimodal Treatment Strategies

Polymers, Год журнала: 2025, Номер 17(9), С. 1258 - 1258

Опубликована: Май 5, 2025

Conjugated polymers (CPs) have emerged as promising candidates for photodynamic therapy (PDT) in cancer treatment due to their high fluorescence quantum yield, excellent photostability, and remarkable reactive oxygen species (ROS) generation capability. This review systematically summarizes molecular design strategies augment CP photosensitivity efficiency, including: (1) constructing donor–acceptor (D-A) alternating structures, (2) incorporating aggregation-induced emission (AIE) moieties, (3) employing heavy-atom effects, (4) designing hyperbranched architectures. In addition, considering the limitations of monotherapy like tumor heterogeneity, we will further discuss synergistic CP-mediated PDT combination with other therapeutic modalities, including photothermal (PTT)-PDT, immunotherapy-PDT, chemotherapy-PDT, Chemiluminescence (CL)-PDT, diagnostic technology-PDT, chemodynamic (CDT)-PDT. These multimodal approaches leverage complementary mechanisms achieve enhanced eradication efficacy.

Язык: Английский

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Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.

Язык: Английский

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Metal-based micro/nanomaterials for hydrogen therapy and their biomedical applications

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review comprehensively explores the biological effects of hydrogen, hydrogen release mechanisms, synthesis methods, and biomedical applications hydrogen-releasing metal-based micro/nanomaterials.

Язык: Английский

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Synthesis of polyacrylic acid-coated AuPd@Fe_xO_y nanoparticles for synergistic chemodynamic and photothermal therapy of osteosarcoma

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

PAA-AuPd@Fe x O y NPs enable pH-responsive T 1 MRI-guided CDT–PTT for osteosarcoma. could generate ˙OH via Fenton reaction and enhance ROS under an 808 nm NIR laser, effectively suppressing MG63 tumor growth in mice.

Язык: Английский

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Tumor Microenvironment-Responsive CA@ZIF-8/MnO 2 Nanoreactor for Self-Reinforcing Cascade Chemodynamic Therapy and Immunomodulation

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 22, 2025

Chemodynamic therapy (CDT), which utilizes endogenous hydrogen peroxide (H₂O₂) to generate hydroxyl radicals (^•OH) via Fenton-like reactions, faces critical limitations in clinical translation, including insufficient intratumoral H₂O₂ levels and glutathione (GSH)-mediated ROS scavenging. To address these challenges, we developed a tumor microenvironment (TME)-responsive nanoreactor, CA@ZIF-8/MnO₂ (CZM), integrating dual functionalities of GSH-depleting self-supplying for cascade-amplified CDT. The ZIF-8 framework serves as biodegradable carrier chlorogenic acid (CA), converts superoxide (O₂^•−) into H₂O₂, while the MnO₂ shell depletes GSH yield Mn²⁺, catalyst. Upon internalization by cells, reacts with produce catalyzes conversion ^•OH, simultaneously depleting enhance CDT efficacy. Additionally, acidic TME triggers release CA, elevates through its self-oxidation property, creating self-reinforcing cycle. In vitro vivo studies demonstrated that CZM NPs not only ^•OH generation but also trigger immunogenic cell death (ICD), promoting antitumor immune responses. Furthermore, promote polarization tumor-associated macrophages towards M1 phenotype, reshaping immunosuppressive TME. RNA-seq pathway analysis further revealed modulate key signaling pathways, NF-κB, induce apoptosis immunity. Overall, findings highlight potential multifunctional nanoplatform immunotherapy.

Язык: Английский

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Polyoxometalate-Containing Nanocomposite Hydrogels for Cascade-Catalytic and Photothermal Dually Enhanced Chemodynamic Therapy

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 27, 2025

Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species (ROS)-mediated cancer therapies. However, lack endogenous hydrogen peroxide (H2O2) tumors and low catalytic efficiency traditional Fenton catalysts limit therapeutic effect CDT. Herein, an injectable nanocomposite hydrogel (HA-DOPA/W-POM/1-S-S-PEG@GOx) based on hyaluronic acid-dopamine (HA-DOPA) matrix is designed to deliver tungsten-based polyoxometalates (W-POM) peptide nanomicelles (1-S-S-PEG@GOx) for achieving cascade-catalytic photothermal dually enhanced Upon tumor cell uptake, 1-S-S-PEG@GOx specifically responds glutathione disassembles release glucose oxidase (GOx), which catalyzes oxidation produce H2O2. On one hand, W-POM functions peroxidase-like nanozymes convert H2O2 into hydroxyl radical (·OH) under aid GOx, enhancing efficacy CDT through reactions (i.e., ·OH). other acts agent, generating mild heat near-infrared laser irradiation achieve photothermal-enhanced This triggers intracellular ROS storm, leading apoptosis ferroptosis cells. Importantly, situ administration HA-DOPA/W-POM/1-S-S-PEG@GOx alongside showcases antitumor satisfactory biocompatibility vivo, holds great potential development functional nanomedicine toward targeted therapy.

Язык: Английский

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Recent progress in hyaluronic acid based nanoparticles for the anti-tumor application

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114860 - 114860

Опубликована: Июнь 1, 2025

Язык: Английский

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Pyroptosis induced by natural products and their derivatives for cancer therapy

Biomaterials Science, Год журнала: 2024, Номер 12(22), С. 5656 - 5679

Опубликована: Янв. 1, 2024

This review is focused on using natural products for cancer therapy by inducing pyroptosis-related signaling pathways. Natural product-based compounds can also be combined with other antitumor therapies a synergistic effect.

Язык: Английский

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