Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(6), P. 065025 - 065025
Published: Oct. 2, 2024
Chemodynamic
therapy
(CDT)
is
a
new
method
for
cancer
treatment
that
produces
highly
toxic
reactive
oxygen
species
(ROS)
in
the
tumor
microenvironment
to
induce
cell
apoptosis
or
necrosis.
However,
therapeutic
effect
of
CDT
often
hindered
by
intracellular
H
Polymers,
Journal Year:
2025,
Volume and Issue:
17(9), P. 1258 - 1258
Published: May 5, 2025
Conjugated
polymers
(CPs)
have
emerged
as
promising
candidates
for
photodynamic
therapy
(PDT)
in
cancer
treatment
due
to
their
high
fluorescence
quantum
yield,
excellent
photostability,
and
remarkable
reactive
oxygen
species
(ROS)
generation
capability.
This
review
systematically
summarizes
molecular
design
strategies
augment
CP
photosensitivity
efficiency,
including:
(1)
constructing
donor–acceptor
(D-A)
alternating
structures,
(2)
incorporating
aggregation-induced
emission
(AIE)
moieties,
(3)
employing
heavy-atom
effects,
(4)
designing
hyperbranched
architectures.
In
addition,
considering
the
limitations
of
monotherapy
like
tumor
heterogeneity,
we
will
further
discuss
synergistic
CP-mediated
PDT
combination
with
other
therapeutic
modalities,
including
photothermal
(PTT)-PDT,
immunotherapy-PDT,
chemotherapy-PDT,
Chemiluminescence
(CL)-PDT,
diagnostic
technology-PDT,
chemodynamic
(CDT)-PDT.
These
multimodal
approaches
leverage
complementary
mechanisms
achieve
enhanced
eradication
efficacy.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
comprehensively
explores
the
biological
effects
of
hydrogen,
hydrogen
release
mechanisms,
synthesis
methods,
and
biomedical
applications
hydrogen-releasing
metal-based
micro/nanomaterials.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
PAA-AuPd@Fe
x
O
y
NPs
enable
pH-responsive
T
1
MRI-guided
CDT–PTT
for
osteosarcoma.
could
generate
˙OH
via
Fenton
reaction
and
enhance
ROS
under
an
808
nm
NIR
laser,
effectively
suppressing
MG63
tumor
growth
in
mice.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(22), P. 5656 - 5679
Published: Jan. 1, 2024
This
review
is
focused
on
using
natural
products
for
cancer
therapy
by
inducing
pyroptosis-related
signaling
pathways.
Natural
product-based
compounds
can
also
be
combined
with
other
antitumor
therapies
a
synergistic
effect.