Overview of Pectin-Derived Microparticles through Microfluidic Technology DOI Creative Commons

Pedro Brivaldo Viana da Silva,

João Paulo Fabi

Fluids, Год журнала: 2024, Номер 9(8), С. 184 - 184

Опубликована: Авг. 16, 2024

The scientific field of microcarrier systems has gained significant advancements, especially in drug delivery and controlled release mechanisms. This manuscript provides a comprehensive overview the progress developing pectin-derived microcarriers fabricated using microfluidic technology. Pectin, naturally occurring polysaccharide, garnered attention due to its biocompatibility, biodegradability, ability form hydrogels, making it an ideal candidate for forming microcarriers. integration technology synthesizing these carriers revolutionized their design functionality, enabling precise control over size, morphology, encapsulation efficiency. review systematically analyzes methodologies employed fabrication pectin-based microparticles, highlighting advantages this offers, such as reduced use solvents, enhanced reproducibility, scalability.

Язык: Английский

Core-Shell Hybrid Liposomes: Transforming Imaging Diagnostics and Therapeutic Strategies DOI Creative Commons
Joana Cunha, Eloah Latocheski,

Ana Fidalgo

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114597 - 114597

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Transforming Nanomaterial Synthesis through Advanced Microfluidic Approaches: A Review on Accessing Unrestricted Possibilities DOI Open Access
Sanjib Baran Roy, Ramesh Kumar,

Argha Acooli

и другие.

Journal of Composites Science, Год журнала: 2024, Номер 8(10), С. 386 - 386

Опубликована: Сен. 25, 2024

The inception of microfluidic devices marks a confluence diverse scientific domains, including physics, biology, chemistry, and fluid mechanics. These multidisciplinary roots have catalyzed the evolution devices, which serve as versatile platforms for various chemical biological processes. Notably, garnered attention efficient reactors, offering distinct benefits such minimized spatial requirements reactions, reduced equipment costs, accelerated residence times. advantages, among others, ignited compelling interest in harnessing technology conception, refinement, production nanomaterials nanocomposites, pivotal within both industrial medicinal sectors. This comprehensive exposition delves into multifaceted aspects nanomaterial synthesis, underscoring transformative role methodologies departure from conventional techniques. discourse navigates through intricate considerations surrounding preparation nanomaterials, elucidating how paradigm has emerged promising alternative. paper serves an illuminating exploration juncture between innovation synthesis. It traverses potential microfluidics revolutionizing traditional approaches, heralding new era precision engineering advanced materials with applications spanning to domains.

Язык: Английский

Процитировано

6

Nanocarriers in Skin Cancer Treatment: Emerging Drug Delivery Approaches and Innovations. DOI Creative Commons
L. D. Jadhav, Satish K. Mandlik

Nano TransMed, Год журнала: 2024, Номер unknown, С. 100068 - 100068

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

6

Utilizing Nanomaterials in Microfluidic Devices for Disease Detection and Treatment DOI Creative Commons
Zhenyu Tian, Yatian Fu, Zhaolong Dang

и другие.

Nanomaterials, Год журнала: 2025, Номер 15(6), С. 434 - 434

Опубликована: Март 12, 2025

Microfluidic technology has gained widespread application in the field of biomedical research due to its exceptional sensitivity and high specificity. Particularly when combined with nanomaterials, synergy between two significantly advanced fields such as precision medicine, drug delivery, disease detection, treatment. This article aims provide an overview latest achievements microfluidic nanomaterials detection It delves into applications detecting blood parameters, cardiovascular markers, neurological tumor markers. Special emphasis is placed on their roles treatment, including models vessels, blood–brain barrier, lung chips, tumors. The development emerging medical technologies, particularly skin interactive devices imaging, also introduced. Additionally, challenges future prospects current clinical are discussed. In summary, play indispensable role With continuous advancement technology, will become even more profound extensive.

Язык: Английский

Процитировано

0

Microfluidic Synthesis of Trastuzumab-Encapsulated pH-Responsive ZIF-67 Nanoparticles for Targeted Drug Delivery DOI
Mina Naderi,

Ataallah Soltani Goharrizi,

Hongkai Wu

и другие.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136881 - 136881

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

(Re)evolution in nanoparticles-loaded microneedle delivery systems: are we getting closer to a clinical translation? DOI
Antonio José Guillot, Ana Melero

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 13

Опубликована: Апрель 21, 2025

The deposition of drug-loaded nanoparticles within the skin structure has been a challenge due to inexorable barrier function. Unless specific like liposomes and lipid-based related vesicles, most cannot penetrate epidermal layers by themselves. This is reason why microneedle-based systems are nowadays straightforward in research. They can greatly bypass stratum corneum deposit supramolecular cargo entities dermal layers, which perform features such as drug-controlled release, targeting or stimuli-responsive behaviors. At this point, after more than 20 years research using nanoparticle-microneedle combination all positive results, clinical experience still so limited. Therefore, how it possible that everlasting promise translation these not reached real practice? In piece work, based on authors' review, series limiting factors regulatory framework guidelines identified discussed, while highlighted revolutionary advances biomedical field 3D-printing technology microfluidics will contribute accelerate nanoparticle-microneedle-based devices make their use entrance market.

Язык: Английский

Процитировано

0

Tracking the electrocatalytic activity of Au@Ag core–shell nanoparticles for nitrite oxidation via single-entity electrochemistry DOI

Aruchamy Gowrisankar,

Byung‐Kwon Kim

Journal of Electroanalytical Chemistry, Год журнала: 2024, Номер 974, С. 118757 - 118757

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1

Recent Advances in Microfluidic Technologies for Stimuli-Sensitive Alginate Particles: Applications in Biosensing and Drug Delivery DOI

Aliakbar Ebrahimiverkiani,

Seyed Morteza Naghib,

Ghobad Shafiei Sabet

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 118124 - 118124

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1

Efficient internalization of poly(benzyl malate) and poly(ethylene glycol)-b-poly(benzyl malate) copolymer based nanoparticles by human hepatic HepaRG cells and macrophages : Impact of nanoparticle functionalization by GBVA10-9 peptide on cell uptake. DOI Open Access

Hanadi Nahas,

Saad Saba,

Perla METLEJ

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 26, 2024

In the past years, we have designed biodegradable poly(benzyl malate) (PMLABe73) homopolymer and amphiphilic poly(ethylene glycol)-b-PMLABe (PEG42-b-PMLABe73) copolymer several modified (co)polymers to produce biocompatible polymeric nanoparticles (NPs) capable of targeting hepatic cells in vitro with goal develop applications treatment liver diseases. The current study aimed at comparing uptake PMLABe73 PEG42-b-PMLABe73-based NPs human HepaRG cells, primary macrophages peripheral blood mononuclear (PBMC). prepared from PEG42-b-PMLABe73 was significantly lower than that both macrophages. addition, by inversely correlated density PEG present on their surface. contrast, internalization PMLABe-based not affected low densities, only fully pegylated PEG42-b-PMLABe73based-NPs decreased. Herein, also showed did strongly accumulated PBMC, T lymphocytes neutrophils while monocytes slightly higher these NPs. Moreover, further demonstrated PMLABe-derived trigger inflammasome activation secretion pro-inflammatory cytokines neither nor cells. Then, peptide GBVA10-9 derived George Baker (GB) Virus A, known exhibit a good hepatotropism affect PMLABe73-based macrophages, when grafted onto results demonstrate are very efficiently internalized hepatocytes but PBMC reinforce our previous reports regarding biocompatibility.

Язык: Английский

Процитировано

0

Overview of Pectin-Derived Microparticles through Microfluidic Technology DOI Creative Commons

Pedro Brivaldo Viana da Silva,

João Paulo Fabi

Fluids, Год журнала: 2024, Номер 9(8), С. 184 - 184

Опубликована: Авг. 16, 2024

The scientific field of microcarrier systems has gained significant advancements, especially in drug delivery and controlled release mechanisms. This manuscript provides a comprehensive overview the progress developing pectin-derived microcarriers fabricated using microfluidic technology. Pectin, naturally occurring polysaccharide, garnered attention due to its biocompatibility, biodegradability, ability form hydrogels, making it an ideal candidate for forming microcarriers. integration technology synthesizing these carriers revolutionized their design functionality, enabling precise control over size, morphology, encapsulation efficiency. review systematically analyzes methodologies employed fabrication pectin-based microparticles, highlighting advantages this offers, such as reduced use solvents, enhanced reproducibility, scalability.

Язык: Английский

Процитировано

0