Transforming Nanomaterial Synthesis through Advanced Microfluidic Approaches: A Review on Accessing Unrestricted Possibilities

Journal of Composites Science, Journal Year: 2024, Volume and Issue: 8(10), P. 386 - 386

Published: Sept. 25, 2024

The inception of microfluidic devices marks a confluence diverse scientific domains, including physics, biology, chemistry, and fluid mechanics. These multidisciplinary roots have catalyzed the evolution devices, which serve as versatile platforms for various chemical biological processes. Notably, garnered attention efficient reactors, offering distinct benefits such minimized spatial requirements reactions, reduced equipment costs, accelerated residence times. advantages, among others, ignited compelling interest in harnessing technology conception, refinement, production nanomaterials nanocomposites, pivotal within both industrial medicinal sectors. This comprehensive exposition delves into multifaceted aspects nanomaterial synthesis, underscoring transformative role methodologies departure from conventional techniques. discourse navigates through intricate considerations surrounding preparation nanomaterials, elucidating how paradigm has emerged promising alternative. paper serves an illuminating exploration juncture between innovation synthesis. It traverses potential microfluidics revolutionizing traditional approaches, heralding new era precision engineering advanced materials with applications spanning to domains.

Language: Английский

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Nanocarriers in Skin Cancer Treatment: Emerging Drug Delivery Approaches and Innovations.

Nano TransMed, Journal Year: 2024, Volume and Issue: unknown, P. 100068 - 100068

Published: Dec. 1, 2024

Language: Английский

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Core-Shell Hybrid Liposomes: Transforming Imaging Diagnostics and Therapeutic Strategies

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114597 - 114597

Published: Feb. 1, 2025

Language: Английский

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Utilizing Nanomaterials in Microfluidic Devices for Disease Detection and Treatment

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(6), P. 434 - 434

Published: March 12, 2025

Microfluidic technology has gained widespread application in the field of biomedical research due to its exceptional sensitivity and high specificity. Particularly when combined with nanomaterials, synergy between two significantly advanced fields such as precision medicine, drug delivery, disease detection, treatment. This article aims provide an overview latest achievements microfluidic nanomaterials detection It delves into applications detecting blood parameters, cardiovascular markers, neurological tumor markers. Special emphasis is placed on their roles treatment, including models vessels, blood–brain barrier, lung chips, tumors. The development emerging medical technologies, particularly skin interactive devices imaging, also introduced. Additionally, challenges future prospects current clinical are discussed. In summary, play indispensable role With continuous advancement technology, will become even more profound extensive.

Language: Английский

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Microfluidic Synthesis of Trastuzumab-Encapsulated pH-Responsive ZIF-67 Nanoparticles for Targeted Drug Delivery

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136881 - 136881

Published: April 1, 2025

Language: Английский

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(Re)evolution in nanoparticles-loaded microneedle delivery systems: are we getting closer to a clinical translation?

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: April 21, 2025

The deposition of drug-loaded nanoparticles within the skin structure has been a challenge due to inexorable barrier function. Unless specific like liposomes and lipid-based related vesicles, most cannot penetrate epidermal layers by themselves. This is reason why microneedle-based systems are nowadays straightforward in research. They can greatly bypass stratum corneum deposit supramolecular cargo entities dermal layers, which perform features such as drug-controlled release, targeting or stimuli-responsive behaviors. At this point, after more than 20 years research using nanoparticle-microneedle combination all positive results, clinical experience still so limited. Therefore, how it possible that everlasting promise translation these not reached real practice? In piece work, based on authors' review, series limiting factors regulatory framework guidelines identified discussed, while highlighted revolutionary advances biomedical field 3D-printing technology microfluidics will contribute accelerate nanoparticle-microneedle-based devices make their use entrance market.

Language: Английский

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Tracking the electrocatalytic activity of Au@Ag core–shell nanoparticles for nitrite oxidation via single-entity electrochemistry

Journal of Electroanalytical Chemistry, Journal Year: 2024, Volume and Issue: 974, P. 118757 - 118757

Published: Nov. 1, 2024

Language: Английский

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Recent Advances in Microfluidic Technologies for Stimuli-Sensitive Alginate Particles: Applications in Biosensing and Drug Delivery

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 118124 - 118124

Published: Dec. 1, 2024

Language: Английский

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Efficient internalization of poly(benzyl malate) and poly(ethylene glycol)-b-poly(benzyl malate) copolymer based nanoparticles by human hepatic HepaRG cells and macrophages : Impact of nanoparticle functionalization by GBVA10-9 peptide on cell uptake.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

In the past years, we have designed biodegradable poly(benzyl malate) (PMLABe73) homopolymer and amphiphilic poly(ethylene glycol)-b-PMLABe (PEG42-b-PMLABe73) copolymer several modified (co)polymers to produce biocompatible polymeric nanoparticles (NPs) capable of targeting hepatic cells in vitro with goal develop applications treatment liver diseases. The current study aimed at comparing uptake PMLABe73 PEG42-b-PMLABe73-based NPs human HepaRG cells, primary macrophages peripheral blood mononuclear (PBMC). prepared from PEG42-b-PMLABe73 was significantly lower than that both macrophages. addition, by inversely correlated density PEG present on their surface. contrast, internalization PMLABe-based not affected low densities, only fully pegylated PEG42-b-PMLABe73based-NPs decreased. Herein, also showed did strongly accumulated PBMC, T lymphocytes neutrophils while monocytes slightly higher these NPs. Moreover, further demonstrated PMLABe-derived trigger inflammasome activation secretion pro-inflammatory cytokines neither nor cells. Then, peptide GBVA10-9 derived George Baker (GB) Virus A, known exhibit a good hepatotropism affect PMLABe73-based macrophages, when grafted onto results demonstrate are very efficiently internalized hepatocytes but PBMC reinforce our previous reports regarding biocompatibility.

Language: Английский

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Overview of Pectin-Derived Microparticles through Microfluidic Technology

Fluids, Journal Year: 2024, Volume and Issue: 9(8), P. 184 - 184

Published: Aug. 16, 2024

The scientific field of microcarrier systems has gained significant advancements, especially in drug delivery and controlled release mechanisms. This manuscript provides a comprehensive overview the progress developing pectin-derived microcarriers fabricated using microfluidic technology. Pectin, naturally occurring polysaccharide, garnered attention due to its biocompatibility, biodegradability, ability form hydrogels, making it an ideal candidate for forming microcarriers. integration technology synthesizing these carriers revolutionized their design functionality, enabling precise control over size, morphology, encapsulation efficiency. review systematically analyzes methodologies employed fabrication pectin-based microparticles, highlighting advantages this offers, such as reduced use solvents, enhanced reproducibility, scalability.

Language: Английский

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