Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 6, 2024
As
a
mechanism
of
cell
death,
ferroptosis
has
gained
popularity
since
2012.
The
process
is
distinguished
by
iron
toxicity
and
phospholipid
accumulation,
in
contrast
to
autophagy,
apoptosis,
other
death
mechanisms.
It
implicated
the
advancement
multiple
diseases
across
body.
Researchers
currently
know
that
osteosarcoma,
osteoporosis,
orthopedic
disorders
are
caused
NRF2,
GPX4,
star
proteins.
effective
relief
osteoarthritis
symptoms
from
deterioration
been
confirmed
clinical
treatment
with
inhibitors.
At
same
time,
it
should
be
reminded
mechanisms
involved
regulate
not
understood.
In
this
manuscript,
we
present
discovery
ferroptosis,
role
variety
diseases.
We
expect
manuscript
can
provide
new
perspective
on
diagnosis
related
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 27, 2024
The
proficient
handling
of
diabetic
wounds,
a
rising
issue
coinciding
with
the
global
escalation
diabetes
cases,
poses
significant
clinical
difficulties.
A
range
biofunctional
dressings
have
been
engineered
and
produced
to
expedite
healing
process
wounds.
This
study
proposes
multifunctional
hydrogel
dressing
for
wound
healing,
which
is
composed
Polyvinyl
Alcohol
(PVA)
N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1,
N1,
N3,
N3-teramethylpropane-1,
3-diaminium
(TSPBA),
dual-drug
loaded
Gelatin
methacryloyl
(GM)
microgel.
GM
microgel
sodium
fusidate
(SF)
nanoliposomes
(LP)
that
contain
metformin
hydrochloride
(MH).
Notably,
adhesive
self-healing
properties
enhance
their
therapeutic
potential
ease
application.
In
vitro
assessments
indicate
SF-infused
can
eliminate
more
than
98%
bacteria
within
24
h
maintain
sustained
release
over
15
days.
Additionally,
MH
incorporated
has
demonstrated
effective
glucose
level
regulation
duration
exceeding
demonstrates
ability
neutralize
ROS
throughout
entire
process,
predominantly
by
electron
donation
sequestration.
dressing,
integrated
biological
functions
efficient
bactericidal
activity
against
both
MSSA
MRSA
strains,
blood
modulation,
control
active
oxygen
levels,
successfully
promoted
wounds
in
rats
14
exhibited
effectiveness
facilitating
highlighting
its
considerable
promise
translation.
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 979 - 979
Опубликована: Июль 24, 2024
Intervertebral
disc
degeneration
(IVDD)
stands
as
the
foremost
contributor
to
low
back
pain
(LBP),
imposing
a
substantial
weight
on
world
economy.
Traditional
treatment
modalities
encompass
both
conservative
approaches
and
surgical
interventions;
however,
former
falls
short
in
halting
IVDD
progression,
while
latter
carries
inherent
risks.
Hence,
quest
for
an
efficacious
method
reverse
onset
is
paramount.
Biomaterial
delivery
systems,
exemplified
by
hydrogels,
microspheres,
microneedles,
renowned
their
exceptional
biocompatibility,
biodegradability,
biological
efficacy,
mechanical
attributes,
have
found
widespread
application
bone,
cartilage,
various
tissue
engineering
endeavors.
Consequently,
IVD
has
emerged
burgeoning
field
of
interest.
This
paper
succinctly
introduces
intervertebral
(IVD)
structure
pathophysiology
IVDD,
meticulously
classifies
biomaterials
repair,
reviews
recent
advances
field.
Particularly,
strengths
weaknesses
are
emphasized,
potential
avenues
future
research
suggested.
