Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Язык: Английский

Cuproptosis and copper as potential mechanisms and intervention targets in Alzheimer's disease DOI Open Access
Yinghong Li, Ying Han, Qi Shu

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 183, С. 117814 - 117814

Опубликована: Янв. 13, 2025

Язык: Английский

Процитировано

4

Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy DOI
Yuanying Yang, Chen Dong, Xuehua Ma

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Язык: Английский

Процитировано

2

Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis DOI

Wenqian Zheng,

Yang Liu, Jinru Liu

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137337 - 137337

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

A hyaluronic acid modified copper-based metal-organic framework overcomes multidrug resistance via two-way redox dyshomeostasis under hypoxia DOI

Jiajia Sun,

Xingwang An,

Yi Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140148 - 140148

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Harnessing nanomaterials for copper-induced cell death DOI

Su-Ran Li,

Shi-Yue Tao,

Qian Li

и другие.

Biomaterials, Год журнала: 2024, Номер 313, С. 122805 - 122805

Опубликована: Сен. 3, 2024

Язык: Английский

Процитировано

5

Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy DOI Creative Commons

Sai‐Nan Zhang,

Qibo Huang,

Tuo Ji

и другие.

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Окт. 31, 2024

Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis critical human health, its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities metal ion regulation interact with fate. This review insights into the complex mechanisms metabolism, molecular basis cuproptosis, association cancer development. We assess role cuproptosis-related genes (CRGs) associated tumorigenesis, their importance prognostic indicators targets, impact on tumor microenvironment (TME) immune response. Ultimately, this highlights interplay between copper, immunotherapy.

Язык: Английский

Процитировано

5

Effective Amplification of Oxidative Stress and Calcium Manipulation Mediated Mitochondrial Dysfunction Based on Engineered Nanozyme for Primary and Metastatic Breast Cancer Therapy DOI
Handan Zhang,

Tianfeng Yang,

Wenyun Mu

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Abstract Herein, an engineered nanocomposite (FZS HC ) was constructed containing zinc‐based nanozyme(ZS), Hemin and Ca 2+ ions with further surface modification of phospholipid folic acid (FA) for primary metastatic breast cancer therapy. During therapy, the FZS initially accumulated in tumor tissues through enhanced permeability retention effectand FA receptor‐mediated tumor‐targeting delivery. After that, dissociated to free loaded ZS acidic environment lysosome. The resulting then generated reactive oxygen species (ROS) consumed glutathione via peroxidase oxidase mimicking enzyme activities induce tumor‐specific ferroptosis elimination, which ROS production could be promoted by catalyzed Fenton‐likereactions amplify oxidative damage accelerate ferroptosis. Furthermore, also influenced calcium metabolism cells, causingthe ‐overloading mitochondrial dysfunction cell salong introduction exogenous , resulted suppression adenosine triphosphate synthesis hinder energy supply cells significant inhibition metastasis. Both vitro vivo results demonstrated remarkable therapeutic slmult1 efficiencyof nanozyme suppressing growth metastasis breastcancer.

Язык: Английский

Процитировано

0

A self-accelerating ‘copper bomb’ strategy activated innate and adaptive immune response against triple-negative breast cancer DOI

Xinzhi Xu,

Hang Zhou,

Ruixia Hong

и другие.

Bioactive Materials, Год журнала: 2025, Номер 49, С. 193 - 206

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0

Dual-Functional Micelles for Codelivery of Sorafenib and Dehydrodiisoeugenol in Treatment of Hepatocellular Carcinoma DOI

Shuo Yang,

Shutong Li, Tianhua Li

и другие.

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

0

GSH-responsive targeted copper-based nanoparticle improve ovarian cancer treatment via induction of apoptosis-ferroptosis-cuproptosis DOI Creative Commons
Lan Ma,

Sihong Guo,

Xinlei Yang

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 113944 - 113944

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0