ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
The
oxygen
consumption
during
chemodynamic
therapy
(CDT)
can
lead
to
severe
cellular
hypoxia,
resulting
in
an
increase
the
hypoxia
inducible
factor-1α
(HIF-1α)
level,
which
hinders
effectiveness
of
CDT
and
induces
tumor
metastasis.
Here,
we
propose
a
strategy
synergistic
between
HIF-1α
inhibitor
avoid
limitations
reduce
risk
Herein,
based
on
coordination
Fe3+
apigenin
(API,
inhibitor),
constructed
hyaluronic
acid
(HA)-modified
API-Fe
nanoparticles
(AF@HA
NPs)
for
synergetic
chemotherapy
glutathione
(GSH)-activated
self-enhancing
CDT.
AF@HA
NPs
have
high
drug
loading
capacity,
stability,
biocompatibility.
Furthermore,
overexpressed
GSH
cancer
cells
Fe2+,
weakened
API
Fe,
promoted
release
chemotherapy.
Fe2+
could
react
with
endogenous
H2O2
generate
hydroxyl
groups
In
addition,
released
inhibit
expression
sensitivity
reactive
species
(ROS),
thereby
achieving
effect
results
vitro
vivo
experiments
indicated
that
effectively
growth
suppress
lung
metastasis
cells.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Biomarker Research,
Год журнала:
2024,
Номер
12(1)
Опубликована: Окт. 31, 2024
Copper
is
an
important
trace
element
for
maintaining
key
biological
functions
such
as
cellular
respiration,
nerve
conduction,
and
antioxidant
defense.
Maintaining
copper
homeostasis
critical
human
health,
its
imbalance
has
been
linked
to
various
diseases,
especially
cancer.
Cuproptosis,
a
novel
mechanism
of
copper-induced
cell
death,
provides
new
therapeutic
opportunities
metal
ion
regulation
interact
with
fate.
This
review
insights
into
the
complex
mechanisms
metabolism,
molecular
basis
cuproptosis,
association
cancer
development.
We
assess
role
cuproptosis-related
genes
(CRGs)
associated
tumorigenesis,
their
importance
prognostic
indicators
targets,
impact
on
tumor
microenvironment
(TME)
immune
response.
Ultimately,
this
highlights
interplay
between
copper,
immunotherapy.
Abstract
Herein,
an
engineered
nanocomposite
(FZS
HC
)
was
constructed
containing
zinc‐based
nanozyme(ZS),
Hemin
and
Ca
2+
ions
with
further
surface
modification
of
phospholipid
folic
acid
(FA)
for
primary
metastatic
breast
cancer
therapy.
During
therapy,
the
FZS
initially
accumulated
in
tumor
tissues
through
enhanced
permeability
retention
effectand
FA
receptor‐mediated
tumor‐targeting
delivery.
After
that,
dissociated
to
free
loaded
ZS
acidic
environment
lysosome.
The
resulting
then
generated
reactive
oxygen
species
(ROS)
consumed
glutathione
via
peroxidase
oxidase
mimicking
enzyme
activities
induce
tumor‐specific
ferroptosis
elimination,
which
ROS
production
could
be
promoted
by
catalyzed
Fenton‐likereactions
amplify
oxidative
damage
accelerate
ferroptosis.
Furthermore,
also
influenced
calcium
metabolism
cells,
causingthe
‐overloading
mitochondrial
dysfunction
cell
salong
introduction
exogenous
,
resulted
suppression
adenosine
triphosphate
synthesis
hinder
energy
supply
cells
significant
inhibition
metastasis.
Both
vitro
vivo
results
demonstrated
remarkable
therapeutic
slmult1
efficiencyof
nanozyme
suppressing
growth
metastasis
breastcancer.
