Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications
Discover Materials,
Год журнала:
2025,
Номер
5(1)
Опубликована: Янв. 9, 2025
Achieving
the
ideal
replacement
for
robust
biological
tissues
requires
biocompatible
materials
with
a
nuanced
blend
of
characteristics,
including
organ
specific
toughness,
durability,
self-repairing
capability,
and
well-defined
structure.
Hydrogels,
structured
high
water
containing
3D-crosslinked
polymeric
networks,
present
promising
avenue
in
biomedical
applications
due
to
their
close
resemblance
natural
tissues.
However,
mechanical
performance
often
falls
short,
limiting
clinical
applications.
Recent
research
has
been
focused
on
developing
hydrogel
therapeutic
advancements
have
spurred
researchers
develop
hydrogels
having
acceptable
toughness.
While
it
is
now
possible
tailor
properties
synthetic
gels
mimic
those
tissues,
critical
aspects
such
as
biocompatibility
crosslinking
strategies
are
frequently
neglected.
This
review
scrutinizes
structural
techniques
designed
improve
toughness
hydrogels,
focusing
especially
innovative
efforts
integrate
these
enhancements
into
natural-based
hydrogels.
By
thoroughly
examining
methodologies,
sheds
light
complexities
strengthening
will
propose
valuable
insights
development
next-generation
tissue
substitutes.
Язык: Английский
Tailoring Design of Microneedles for Drug Delivery and Biosensing
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
Язык: Английский
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Abstract
Recent
strides
in
non‐invasive
drug
delivery
have
spurred
innovation
alternatives
to
traditional
needle
injections.
Transdermal
systems
(TDDs)
emerged
as
a
particularly
promising
avenue,
boasting
minimal
rejection
rates,
user‐friendly
administration,
and
enhanced
patient
adherence.
Beyond
pharmaceuticals,
TDDs
show
potential
skincare
cosmetics,
leveraging
their
ability
facilitate
localized
while
minimizing
systemic
exposure.
Nonetheless,
the
intricate
physicochemical
nature
of
skin
presents
formidable
obstacles,
prompting
intensive
exploration
overcome
these
barriers.
This
comprehensive
review
delves
into
landscape
methodologies,
critically
analyzing
respective
advantages,
limitations,
characterization
prospective
applications.
advancements
underscore
robust
efficacy
TDDs,
positioning
it
versatile
indispensable
modality
poised
for
widespread
integration
across
multifarious
fields.
Язык: Английский