Nanozymes as Antibacterial Agents: New Concerns in Design and Enhancement Strategies DOI
Xianhang Yan, Xiaoqiang Li,

Pei‐Kai Yu

и другие.

ChemBioChem, Год журнала: 2024, Номер 26(1)

Опубликована: Окт. 21, 2024

Abstract Nanozymes exhibiting natural enzyme‐mimicking catalytic activities as antibacterial agents present several advantages, including high stability, low cost, broad‐spectrum activity, ease of preparation and storage, minimal bacterial resistance. Consequently, they have attracted significant attention in recent years. However, the rapid expansion antimicrobial nanozyme research has resulted pioneering reviews that do not comprehensively address emerging concerns enhancement strategies within this field. This paper first summarizes factors influencing intrinsic activity nanozymes; subsequently, we outline new considerations for designing nanozymes with enhanced functionality biosafety features such degradable, imageable, targeted, bacterial‐binding well those capable selectively targeting pathogenic bacteria while sparing normal cells probiotics. Furthermore, review novel involving external physical stimuli (light or ultrasound), introduction extrinsic small molecules, self‐supplying H 2 O to enhance under physiological conditions characterized by concentrations . Additionally, non‐redox operate independently highly toxic reactive oxygen species (ROS) alongside designed combat less common bacteria. Finally, discuss current issues, challenges faced field, future prospects nanozymes.

Язык: Английский

Iron-doped carbon dots nanozyme scavenged reactive oxygen species system for inhibiting effectively the uptake of arsenic in lettuce DOI

Meihua Xie,

Feiyu Li, Yueying Li

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159956 - 159956

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Bioactive Decellularized Extracellular Matrix Platform Integrating Multifunctional Nanozymes and Cell-Laden Microgels for Acute Liver Failure Treatment DOI
Gang Xiao, Jiabin Zhang, Tong Lin

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Mesenchymal stem cell (MSC) therapy has emerged as a promising alternative approach for treating acute liver failure (ALF) while confronting the shortage of low efficiency and poor engraftment within hostile milieu. In this study, we establish bioactive decellularized extracellular matrix (dECM) platform that incorporates dihydrolipoic acid (DHLA)-protected Pt nanoclusters doped with Cu (PtCu-DHLA) nanozymes cell-laden microgels. The PtCu-DHLA nanozymes, selected their versatility, function antioxidant, anti-inflammatory, pro-proliferative, pro-angiogenic agents, enhancing ALF alleviation providing an optimal microenvironment MSC transplantation. Additionally, methacrylic anhydride (MA)-modified porcine liver-derived (PLdECM) hydrogel (PLdECMMA) been developed construction microgels via microfluidic devices. Interferon γ (IFNγ) preconditioned MSCs encapsulated in PLdECMMA exhibit enhanced immunomodulating activity prolonged survival. are codelivered by leveraging PLdECM orthotopic transplanted dECM enables efficient successful rescue CCl4-induced counteracting oxidative stress, suppressing inflammatory storms, promoting cellular regeneration. Overall, study highlights synergistic reinforced strategy combines biomimetic therapy, offering significant potential treatment broader applications regenerative medicine.

Язык: Английский

Процитировано

2
Rational Design of Single‐Atom Nanozymes for Combination Cancer Immunotherapy DOI Open Access

Hanchao Lin,

Yonghui Gao,

Le Zhu

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract Remodeling of the tumor immune microenvironment and enhancement antitumor responses are necessary to overcome immunotherapy resistance in tumors. However, heterogeneity complexity evasion mechanisms pose significant therapeutic challenges. Nanozymes exhibit enzyme‐like characteristics unique nanomaterial properties, showing potential for therapy. design effective nanozymes remains complex, inefficient, functionally limited. Therefore, this study, a novel strategy combining rationally designed single‐atom (SAzymes) with checkpoint blockade (ICB) therapy is established. Molybdenum SAzymes supported on graphitic carbon nitride (Mo SAs) constructed using 25 transition metal candidates from 4th 6th periods based high‐throughput calculations optimal piezoelectric‐enhanced multienzyme‐like activities. Upon activation by ultrasound, Mo SAs exerted potent effects against ICB‐resistant tumors remodeled inducing immunogenic cell death, alleviating hypoxia, modulating chemokine expression Combination anti‐programmed death protein‐1 antibodies further enhanced their efficacy, highlighting treat

Язык: Английский

Процитировано

1
Dual-Nanozyme Cascade for System-Wide Specific Colorimetric Detection of Aminoglycoside Antibiotics DOI

Ziyi Gao,

Yujun Cheng,

Chuan Long

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Antibiotic contamination has been a significant concern in environmental monitoring. Nanozyme-based colorimetric sensors can provide valuable support for in-field detection. However, the development of sensing elements capable identifying an entire class specific antibiotics using single material poses considerable challenge. In this work, we present compartmentalized dual-nanozyme cascade composite (Au@mPDA/PAA-Cu2MI, AmPC) designed detection aminoglycoside (AGs), and analyze catalytic mechanisms dual-enzyme system detail. The AmPC possesses both analogue glucose oxidase-like (aGOx-like) peroxidase-like (POD-like) activities. process, AGs with sugar structure serve as initial substrate reaction, while resulting H2O2 acts second Using gentamicin (GMC) proof concept, established range 0.1-10 μg/mL, limit (LOD) 91 ng/mL. addition, validated response other employed principal component analysis (PCA) differentiating among various AGs. This approach enables nanozymes to selectively recognize their targets through mechanism. Furthermore, it facilitates simultaneous identification antibiotics, highlighting its potential applications.

Язык: Английский

Процитировано

0
A comprehensive review on the recent applications of nanozymes in breast cancer therapy and diagnosis DOI Creative Commons

Amir Kashtiaray,

Mahdi Karimi, Mostafa Ghafori-Gorab

и другие.

Materials Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Nanozymes have been developed as engineered nanomaterials that mimic the catalytic functions of natural enzymes.

Язык: Английский

Процитировано

0
Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment DOI Creative Commons
Si-Jie Zhang, Ran Xu, Shao‐Bin He

и другие.

Military Medical Research, Год журнала: 2025, Номер 12(1)

Опубликована: Май 31, 2025

Abstract The treatment of chronic wounds presents significant challenges due to the necessity accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances. Factors such as bacterial infections, hyperglycemia, oxidative stress disrupt cellular functions impair angiogenesis, substantially delaying wound repair. Nanozymes, which are engineered nanoscale materials with enzyme-like activities, offer distinct advantages over conventional enzymes traditional nanomaterials, making them promising candidates for treatment. To enhance their clinical potential, nanozyme-based catalytic systems currently being optimized through formulation advancements preclinical studies assessing biocompatibility, anti-oxidant activity, antibacterial efficacy, tissue repair capabilities, ensuring safety applicability. When integrated into multifunctional dressings, nanozymes modulate reactive oxygen species levels, promote regeneration, simultaneously combat infections damage, extending beyond catalysis in customizable architectures enable precise therapeutic applications, enhancing effectiveness managing conditions. This review provides a comprehensive analysis incorporation detailing fabrication methods emphasizing transformative potential management. By identifying addressing key limitations, we introduce strategic drive development nanozyme-driven paving way next-generation treatments.

Язык: Английский

Процитировано

0
Nanozymes as Antibacterial Agents: New Concerns in Design and Enhancement Strategies DOI
Xianhang Yan, Xiaoqiang Li,

Pei‐Kai Yu

и другие.

ChemBioChem, Год журнала: 2024, Номер 26(1)

Опубликована: Окт. 21, 2024

Abstract Nanozymes exhibiting natural enzyme‐mimicking catalytic activities as antibacterial agents present several advantages, including high stability, low cost, broad‐spectrum activity, ease of preparation and storage, minimal bacterial resistance. Consequently, they have attracted significant attention in recent years. However, the rapid expansion antimicrobial nanozyme research has resulted pioneering reviews that do not comprehensively address emerging concerns enhancement strategies within this field. This paper first summarizes factors influencing intrinsic activity nanozymes; subsequently, we outline new considerations for designing nanozymes with enhanced functionality biosafety features such degradable, imageable, targeted, bacterial‐binding well those capable selectively targeting pathogenic bacteria while sparing normal cells probiotics. Furthermore, review novel involving external physical stimuli (light or ultrasound), introduction extrinsic small molecules, self‐supplying H 2 O to enhance under physiological conditions characterized by concentrations . Additionally, non‐redox operate independently highly toxic reactive oxygen species (ROS) alongside designed combat less common bacteria. Finally, discuss current issues, challenges faced field, future prospects nanozymes.

Язык: Английский

Процитировано

1