Efficiently radiation-induced degradation and extraction of Polygonatum sibiricum polysaccharides and its excellent ROS scavenging properties

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159717 - 159717

Опубликована: Янв. 1, 2025

Язык: Английский

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Design of acidic activation-responsive charge-switchable carbon dots and validation of their antimicrobial activity

RSC Advances, Год журнала: 2025, Номер 15(7), С. 5413 - 5425

Опубликована: Янв. 1, 2025

Bacterial biofilms play a crucial role in the emergence of antibiotic resistance and persistence chronic infections.

Язык: Английский

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Novel intelligent naked-eye food packaging pH-sensitive and fluorescent sulfur, nitrogen-carbon dots biosensors for tomato spoilage detection including DFT and molecular docking characterization

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143330 - 143330

Опубликована: Апрель 1, 2025

Язык: Английский

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Anti-Tumor Activity and Mechanism of Apoptosis of Cne Cells Induced by Acylhydrazone Based Complexes

Опубликована: Янв. 1, 2025

Язык: Английский

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Carbon dot based dressing for therapy of chemically-induced cutaneous burns

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 31, 2025

Chemical burns are a significant concern in Ukraine, with growing interest new treatments. Carbon-based nanoparticles, due to their anti-inflammatory, antioxidant, and antibacterial properties, have shown promise for wound healing. This study aimed evaluate the efficacy of carbon dots (CD) derived from citric acid urea promoting healing both acidic- alkali-induced rat model. The results indicated that acid-induced were slower heal exhibited more inflammation compared same initial injury level. Daily application CD dressings significantly reduced burn area during first week, i.e. accelerated process, although treatment was less effective burns. Both types led increased white blood cell counts, left shift, segmented neutrophils by day 7, signaling early acute inflammation. notably leukocytosis while preserving neutrophilia lymphocyte release on days 7 14. Furthermore, prevented post-burn anemia maintaining erythrocyte integrity. immune system's response levels consistent process skin histopathology.Overall, healing, particularly alkali burns, had systemic effect inflammatory responses.

Язык: Английский

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Nanoarchitectonics with Zinc-Doped Carbon Dots for Mitochondria-Targeted Repair and Regeneration Signaling Amplification in CLI Therapy

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Critical limb ischemia (CLI) faces high rates of amputation and mortality. Despite advancements in surgical endovascular interventions, their invasiveness restricted applicability leave many CLI patients classified as "no-option" cases. Therapeutic angiogenesis strategies offer prospects for revascularization, but efficacy remains suboptimal. Herein, we developed a nanomedicine, mitochondria-targeted zinc-doped ascorbic acid-derived carbon dots (TPP-Zn@ACDs), which simultaneously restores mitochondrial function amplifies regenerative signaling to synergistically boost ischemic limbs. TPP-Zn@ACDs integrate potent antioxidative properties the pro-regenerative effects Zn2+, with triphenylphosphine (TPP) polyethylene glycol (PEG) functionalization endowing precise targeting enhanced biocompatibility, thereby localizing therapeutic core oxidative stress mitigation transduction. In vitro, improved by reducing reactive oxygen species, restoring membrane potential enhancing ATP production, through activation SIRT1/PGC-1α pathway. Further, proliferation, migration, tube formation activities endothelial cells were increased, while hypoxia-induced apoptosis necrosis was inhibited effectively. Notably, leveraging restoration cells, subsequently reprogrammed macrophages from an M1 pro-inflammatory phenotype M2 anti-inflammatory phenotype. vivo, demonstrated remarkable mouse model, achieving robust blood flow recovery, increased microvascular density, immune microenvironment. Together, this study proposes versatile engineering nanomedicine therapy, providing scalable approach breakthrough angiogenic diseases.

Язык: Английский

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Ampicillin-derived carbon dots as the sensitive probe for the detection of Fe3+ and Cu2+ in living cells and water samples

Microchimica Acta, Год журнала: 2024, Номер 191(12)

Опубликована: Ноя. 25, 2024

Язык: Английский

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