Injectable Polysaccharide-Based Hydrogel with Glucose Responsiveness as an Immunoregulatory Platform for Enhanced Diabetic Wound Healing
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 22, 2025
Persistent
excessive
inflammatory
response
in
diabetic
wounds
caused
by
the
imbalance
of
immune
microenvironment
leads
to
delayed
or
nonhealing
wounds.
Timely
attenuation
inflammation
through
immunoregulation
is
a
crucial
strategy
accelerate
wound
closure.
Here,
protocatechuic
acid
(PCA)-
and
deferoxamine
(DFO)-loaded
polysaccharide-based
immunoregulatory
hydrogel
(POCP@D)
was
developed
dual-cross-linking
borate
ester
bonds
imine
promote
advanced
healing
full-thickness
The
POCP@D
showed
good
tissue
adhesiveness
property,
flexibility,
mechanical
strength,
injectability,
self-healing,
glucose-responsive
drug
release
properties,
besides
strong
broad-spectrum
antibacterial
antioxidant
activities.
acted
as
an
platform
remold
vivo
regulating
M2-type
macrophage
polarization
timely
relieving
inflammation,
thus
promoting
collagen
deposition,
angiogenesis,
development
from
stage
proliferative
ultimately
achieving
high-quality
skin
regeneration.
Overall,
our
held
great
potential
for
refractory
therapy
clinical
settings.
Язык: Английский
Recent Advances on Chitosan-Based Thermosensitive Hydrogels for Skin Wound Treatment
Biology,
Год журнала:
2025,
Номер
14(6), С. 619 - 619
Опубликована: Май 27, 2025
Thermosensitive
hydrogel,
as
a
smart
polymer
material,
showed
great
potential
for
application
in
the
field
of
wound
repair
due
to
its
unique
external
temperature
responsiveness
and
excellent
biocompatibility.
Chitosan,
natural
macromolecular
polysaccharide
derived
from
deacetylation
chitin,
possessed
not
only
strong
interactions
with
biomolecules
such
DNA,
proteins,
lipids,
but
also
biocompatibility
degradability.
Chitosan-based
thermosensitive
hydrogels,
prepared
by
compounding
chitosan
surfactants,
underwent
sol–gel
phase
transitions
at
varying
temperatures,
which
provided
an
ideal
healing
environment
wounds.
This
comprehensive
review
was
initiated
elucidating
transformation
mechanism
underlying
hydrogels
intricate
process
repair.
In
addition,
this
detailed
overview
prevalent
types
chitosan-based
highlighting
their
characteristics
applications
different
Finally,
challenges
development
directions
were
discussed,
aiming
provide
theoretical
support
practical
guidance
future
healing.
Язык: Английский