Recent Advances on Chitosan-Based Thermosensitive Hydrogels for Skin Wound Treatment DOI Creative Commons

Jin Wang,

Lianghui Huang,

Enguang Wu

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(6), P. 619 - 619

Published: May 27, 2025

Thermosensitive hydrogel, as a smart polymer material, showed great potential for application in the field of wound repair due to its unique external temperature responsiveness and excellent biocompatibility. Chitosan, natural macromolecular polysaccharide derived from deacetylation chitin, possessed not only strong interactions with biomolecules such DNA, proteins, lipids, but also biocompatibility degradability. Chitosan-based thermosensitive hydrogels, prepared by compounding chitosan surfactants, underwent sol–gel phase transitions at varying temperatures, which provided an ideal healing environment wounds. This comprehensive review was initiated elucidating transformation mechanism underlying hydrogels intricate process repair. In addition, this detailed overview prevalent types chitosan-based highlighting their characteristics applications different Finally, challenges development directions were discussed, aiming provide theoretical support practical guidance future healing.

Language: Английский

Injectable Polysaccharide-Based Hydrogel with Glucose Responsiveness as an Immunoregulatory Platform for Enhanced Diabetic Wound Healing DOI
Ming‐Chien Yang, Yongbin Xu, Qingsu Cheng

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Persistent excessive inflammatory response in diabetic wounds caused by the imbalance of immune microenvironment leads to delayed or nonhealing wounds. Timely attenuation inflammation through immunoregulation is a crucial strategy accelerate wound closure. Here, protocatechuic acid (PCA)- and deferoxamine (DFO)-loaded polysaccharide-based immunoregulatory hydrogel (POCP@D) was developed dual-cross-linking borate ester bonds imine promote advanced healing full-thickness The POCP@D showed good tissue adhesiveness property, flexibility, mechanical strength, injectability, self-healing, glucose-responsive drug release properties, besides strong broad-spectrum antibacterial antioxidant activities. acted as an platform remold vivo regulating M2-type macrophage polarization timely relieving inflammation, thus promoting collagen deposition, angiogenesis, development from stage proliferative ultimately achieving high-quality skin regeneration. Overall, our held great potential for refractory therapy clinical settings.

Language: Английский

Citations

0
Recent Advances on Chitosan-Based Thermosensitive Hydrogels for Skin Wound Treatment DOI Creative Commons

Jin Wang,

Lianghui Huang,

Enguang Wu

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(6), P. 619 - 619

Published: May 27, 2025

Thermosensitive hydrogel, as a smart polymer material, showed great potential for application in the field of wound repair due to its unique external temperature responsiveness and excellent biocompatibility. Chitosan, natural macromolecular polysaccharide derived from deacetylation chitin, possessed not only strong interactions with biomolecules such DNA, proteins, lipids, but also biocompatibility degradability. Chitosan-based thermosensitive hydrogels, prepared by compounding chitosan surfactants, underwent sol–gel phase transitions at varying temperatures, which provided an ideal healing environment wounds. This comprehensive review was initiated elucidating transformation mechanism underlying hydrogels intricate process repair. In addition, this detailed overview prevalent types chitosan-based highlighting their characteristics applications different Finally, challenges development directions were discussed, aiming provide theoretical support practical guidance future healing.

Language: Английский

Citations

0