Drug-caged drug: photoredox catalysis-enabled dual decaging of nitric oxide and local anesthetics for simultaneous antibacterial treatment and pain relief DOI Creative Commons
Jinming Hu, Jiqian Zhang,

Guihai Gan

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Bacterial infections often result in significant pain, negatively impacting patient outcomes and quality of life. Conventional therapies primarily focus on pathogen eradication but frequently overlook the associated thereby limiting their overall clinical effectiveness. Herein, we propose a 'drug-caged drug' strategy which secondary amine group local anesthetic tetracaine (TTC) is selectively caged by nitric oxide (NO), forming TTC-NO prodrug. The prodrug co-loaded with photocatalyst fac-Ir(ppy)3 into poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) micellar nanoparticles (TTC-NO@M), enabling dual uncaging TTC NO under mild visible light irradiation through photocatalytic mechanism. We demonstrate that TTC-NO@M exhibits combined antibacterial, anti-inflammatory, analgesic activities simultaneously releasing TTC. This effectively treats MRSA-infected mice both cutaneous wound septic arthritis models while alleviating infection-associated pain. work offers promising approach to address challenges bacterial

Язык: Английский

Advances in Electrochemical Nitrite Reduction toward Nitric Oxide Synthesis for Biomedical Applications DOI Open Access
Xun He,

Chang Zou,

Limei Zhang

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Nitric oxide (NO) is an essential molecule in biomedicine, recognized for its antibacterial properties, neuronal modulation, and use inhalation therapies. The effectiveness of NO-based treatments relies on precise control NO concentrations tailored to specific therapeutic needs. Electrochemical generation (E-NOgen) via nitrite (NO2 -) reduction offers a scalable efficient route controlled production, while also addressing environmental concerns by reducing NO2 - pollution maintaining nitrogen cycle balance. Recent developments catalysts E-NOgen devices have propelled conversion, enabling on-demand production. This review provides overview pathways, with focus cutting-edge Fe/Cu-based catalysts, explores the development biomedical use. Challenges future directions advancing technologies are discussed.

Язык: Английский

Процитировано

3
Multifunctional Carbon Quantum Dots for Monitoring and Therapy of Bacterial Infected Wounds DOI Open Access
Wenxin Qi, Yihao Liu,

Naijun Dong

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Bacterial infections in wounds and bacteremia present significant global health challenges, driving the urgent need for innovative alternatives to traditional antibiotics. Here, development of PEI-EDTA-2Na carbon quantum dots (PECDs) synthesized via a hydrothermal method is reported. Synthesis conditions affect PECDs' antibacterial efficacy; those at 180 °C have optimal -NH2 functionalization better adhesion activity. PECDs are pH - responsive, eradicating bacteria weakly acidic by disrupting DNA proteins. Following resolution infection, adapt neutral alkaline environments, where they scavenge reactive oxygen species (ROS), reduce inflammation, promote macrophage polarization, accelerate wound healing. Furthermore, significantly improve survival models. Their intrinsic fluorescence enables real-time monitoring wounds, offering non-invasive diagnostic tool. Genomic transcriptomic analyses reveal that disrupt bacterial metabolism resistance pathways, while simultaneously supporting anti-inflammatory responses during tissue repair. This dual functionality-combining therapeutic efficacy healing with antimicrobial properties bacteremia-positions as versatile platform smart management an emerging candidate advanced biomedical applications.

Язык: Английский

Процитировано

3
UiO-based platforms in biomedicine: Advanced nanovehicles for effective treatment DOI

Ren Zhang,

Abdulnasser Mahmoud Karami,

Qianying Huang

и другие.

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102645 - 102645

Опубликована: Март 22, 2025

Язык: Английский

Процитировано

2
Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy DOI
Junjie Zhang, Haiyang Guo, Longguang Tang

и другие.

Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216540 - 216540

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

1
Cascade reaction hydrogel with enzyme-catalyzed endogenous glucose for diabetic wound healing DOI

Ning Wei,

Liangyu Wang, Haibo Wang

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 693, С. 137616 - 137616

Опубликована: Апрель 16, 2025

Язык: Английский

Процитировано

0
Four birds with one Stone: A Lactose-Targeted supramolecular nanoprodrug for combined Photodynamic/Photothermal/NO/ chemotherapy of multidrug resistant cancer DOI
Chang Du, Jianbo Zhang,

Yingnan Zhou

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163787 - 163787

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Nitrosoamine–3-Hydroxyflavothione Hybrids Enable Oxygen-Tolerant Photoredox Catalysis for Red-Light-Stimulated CO/NO Release for Combating Bacteria DOI
Ishaq Lugoloobi, Jian Cheng,

Zhiqiang Shen

и другие.

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 757 - 764

Опубликована: Май 20, 2025

Single gas donors have proved to vast therapeutic potential; however, the investigation of multigas releasing molecules is limited. Besides, porphyrins and their derivatives are essential energy electron transfer agents for activating gaseous signaling molecule (GSM) donors, despite, catalysis latter greatly limited in oxygen-rich environments. We, therefore, report photosensitive small-molecule hybrids composed oxo-/thio-flavonols as singlet oxygen (1O2) scavengers catalytic stability N-nitrosoamine moieties competent co-release carbon monoxide (CO) nitric oxide (NO) amounts that depend on structural designs. The self-assembled micellar co-encapsulation CO/NO PdTPTBP afforded intracellular GSMs delivery during red-light irradiation. bactericidal effect irradiated micelles against planktonic Gram-positive Gram-negative bacteria displayed a significant killing rate S. aureus via membrane hyperpolarization rupture achieved an excellent combination index 0.44. This represents high potential biomedical applications.

Язык: Английский

Процитировано

0
Cu-Fe Bimetallic Peroxide-Based Nanozyme with Microenvironment-Triggered Cascade Catalysis for Synergistic Hydroxyl Radical, Nitric Oxide, and Oxygen Generation in Trimodal Wound Infection Therapy DOI Creative Commons
Wei Liu, Yuan Fang, Ping Xu

и другие.

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101912 - 101912

Опубликована: Май 28, 2025

Язык: Английский

Процитировано

0
Biomimetic Materials for Antibacterial Applications DOI
Junjie Zhang, Heng Dong, Bing Liu

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

The rise of antibiotic resistance poses a critical threat to global health, necessitating the development novel antibacterial strategies mitigate this growing challenge. Biomimetic materials, inspired by natural biological systems, have emerged as promising solution in context. These mimicking entities such plants, animals, cells, viruses, and enzymes, offer innovative approaches combat bacterial infections effectively. This review delves into integration biomimicry with materials science develop agents that are not only effective but also biocompatible less likely induce resistance. study explores design function various biomimetic highlighting their therapeutic potential anti-infection applications. Further, provides comprehensive summary recent advancements field, illustrating how these been engineered enhance efficacy safety. discusses challenges facing transition from laboratory clinical settings, scalability, cost-effectiveness, long-term stability. Lastly, vast opportunities hold for future therapy, suggesting continued research multidisciplinary collaboration will be essential realize full potential.

Язык: Английский

Процитировано

1
Research Progress on Implantable Medical Textiles and Their Surface Functional Coatings DOI Open Access
Hongwei Wang, Yujie Gao, Chong Zhang

и другие.

Journal of Polymer Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 25, 2024

ABSTRACT With changes in people's lifestyles and the escalating pace of population aging, incidence rate chronic diseases has increased annually, posing significant challenges to both individual societal health. Specifically engineered implantable medical textiles have exhibited structural superiority over other material types repairing or replacing damaged tissues organs within body, along with enhancement their functions. They also play important roles treatment management diseases. This review takes several representative textiles, such as artificial blood vessels, ligaments, sutures, examples introduce fundamental features particularities inherent development. In addition, on basis clinical requirements anti‐infection, common strategies for construction antibacterial coatings are summarized. Ultimately, development trend is discussed. Through this review, we aim provide certain insights conception novel textiles.

Язык: Английский

Процитировано

0