Journal of Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 25, 2024
ABSTRACT
With
changes
in
people's
lifestyles
and
the
escalating
pace
of
population
aging,
incidence
rate
chronic
diseases
has
increased
annually,
posing
significant
challenges
to
both
individual
societal
health.
Specifically
engineered
implantable
medical
textiles
have
exhibited
structural
superiority
over
other
material
types
repairing
or
replacing
damaged
tissues
organs
within
body,
along
with
enhancement
their
functions.
They
also
play
important
roles
treatment
management
diseases.
This
review
takes
several
representative
textiles,
such
as
artificial
blood
vessels,
ligaments,
sutures,
examples
introduce
fundamental
features
particularities
inherent
development.
In
addition,
on
basis
clinical
requirements
anti‐infection,
common
strategies
for
construction
antibacterial
coatings
are
summarized.
Ultimately,
development
trend
is
discussed.
Through
this
review,
we
aim
provide
certain
insights
conception
novel
textiles.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Nitric
oxide
(NO)
is
an
essential
molecule
in
biomedicine,
recognized
for
its
antibacterial
properties,
neuronal
modulation,
and
use
inhalation
therapies.
The
effectiveness
of
NO-based
treatments
relies
on
precise
control
NO
concentrations
tailored
to
specific
therapeutic
needs.
Electrochemical
generation
(E-NOgen)
via
nitrite
(NO2
-)
reduction
offers
a
scalable
efficient
route
controlled
production,
while
also
addressing
environmental
concerns
by
reducing
NO2
-
pollution
maintaining
nitrogen
cycle
balance.
Recent
developments
catalysts
E-NOgen
devices
have
propelled
conversion,
enabling
on-demand
production.
This
review
provides
overview
pathways,
with
focus
cutting-edge
Fe/Cu-based
catalysts,
explores
the
development
biomedical
use.
Challenges
future
directions
advancing
technologies
are
discussed.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Bacterial
infections
in
wounds
and
bacteremia
present
significant
global
health
challenges,
driving
the
urgent
need
for
innovative
alternatives
to
traditional
antibiotics.
Here,
development
of
PEI-EDTA-2Na
carbon
quantum
dots
(PECDs)
synthesized
via
a
hydrothermal
method
is
reported.
Synthesis
conditions
affect
PECDs'
antibacterial
efficacy;
those
at
180
°C
have
optimal
-NH2
functionalization
better
adhesion
activity.
PECDs
are
pH
-
responsive,
eradicating
bacteria
weakly
acidic
by
disrupting
DNA
proteins.
Following
resolution
infection,
adapt
neutral
alkaline
environments,
where
they
scavenge
reactive
oxygen
species
(ROS),
reduce
inflammation,
promote
macrophage
polarization,
accelerate
wound
healing.
Furthermore,
significantly
improve
survival
models.
Their
intrinsic
fluorescence
enables
real-time
monitoring
wounds,
offering
non-invasive
diagnostic
tool.
Genomic
transcriptomic
analyses
reveal
that
disrupt
bacterial
metabolism
resistance
pathways,
while
simultaneously
supporting
anti-inflammatory
responses
during
tissue
repair.
This
dual
functionality-combining
therapeutic
efficacy
healing
with
antimicrobial
properties
bacteremia-positions
as
versatile
platform
smart
management
an
emerging
candidate
advanced
biomedical
applications.
ACS Macro Letters,
Год журнала:
2025,
Номер
unknown, С. 757 - 764
Опубликована: Май 20, 2025
Single
gas
donors
have
proved
to
vast
therapeutic
potential;
however,
the
investigation
of
multigas
releasing
molecules
is
limited.
Besides,
porphyrins
and
their
derivatives
are
essential
energy
electron
transfer
agents
for
activating
gaseous
signaling
molecule
(GSM)
donors,
despite,
catalysis
latter
greatly
limited
in
oxygen-rich
environments.
We,
therefore,
report
photosensitive
small-molecule
hybrids
composed
oxo-/thio-flavonols
as
singlet
oxygen
(1O2)
scavengers
catalytic
stability
N-nitrosoamine
moieties
competent
co-release
carbon
monoxide
(CO)
nitric
oxide
(NO)
amounts
that
depend
on
structural
designs.
The
self-assembled
micellar
co-encapsulation
CO/NO
PdTPTBP
afforded
intracellular
GSMs
delivery
during
red-light
irradiation.
bactericidal
effect
irradiated
micelles
against
planktonic
Gram-positive
Gram-negative
bacteria
displayed
a
significant
killing
rate
S.
aureus
via
membrane
hyperpolarization
rupture
achieved
an
excellent
combination
index
0.44.
This
represents
high
potential
biomedical
applications.
The
rise
of
antibiotic
resistance
poses
a
critical
threat
to
global
health,
necessitating
the
development
novel
antibacterial
strategies
mitigate
this
growing
challenge.
Biomimetic
materials,
inspired
by
natural
biological
systems,
have
emerged
as
promising
solution
in
context.
These
mimicking
entities
such
plants,
animals,
cells,
viruses,
and
enzymes,
offer
innovative
approaches
combat
bacterial
infections
effectively.
This
review
delves
into
integration
biomimicry
with
materials
science
develop
agents
that
are
not
only
effective
but
also
biocompatible
less
likely
induce
resistance.
study
explores
design
function
various
biomimetic
highlighting
their
therapeutic
potential
anti-infection
applications.
Further,
provides
comprehensive
summary
recent
advancements
field,
illustrating
how
these
been
engineered
enhance
efficacy
safety.
discusses
challenges
facing
transition
from
laboratory
clinical
settings,
scalability,
cost-effectiveness,
long-term
stability.
Lastly,
vast
opportunities
hold
for
future
therapy,
suggesting
continued
research
multidisciplinary
collaboration
will
be
essential
realize
full
potential.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Abstract
Bacterial
infections
often
result
in
significant
pain,
negatively
impacting
patient
outcomes
and
quality
of
life.
Conventional
therapies
primarily
focus
on
pathogen
eradication
but
frequently
overlook
the
associated
thereby
limiting
their
overall
clinical
effectiveness.
Herein,
we
propose
a
'drug-caged
drug'
strategy
which
secondary
amine
group
local
anesthetic
tetracaine
(TTC)
is
selectively
caged
by
nitric
oxide
(NO),
forming
TTC-NO
prodrug.
The
prodrug
co-loaded
with
photocatalyst
fac-Ir(ppy)3
into
poly(ethylene
glycol)-b-poly(ε-caprolactone)
(PEG-b-PCL)
micellar
nanoparticles
(TTC-NO@M),
enabling
dual
uncaging
TTC
NO
under
mild
visible
light
irradiation
through
photocatalytic
mechanism.
We
demonstrate
that
TTC-NO@M
exhibits
combined
antibacterial,
anti-inflammatory,
analgesic
activities
simultaneously
releasing
TTC.
This
effectively
treats
MRSA-infected
mice
both
cutaneous
wound
septic
arthritis
models
while
alleviating
infection-associated
pain.
work
offers
promising
approach
to
address
challenges
bacterial
