Recent Advances in Nanoenzymes Based Therapies for Glioblastoma: Overcoming Barriers and Enhancing Targeted Treatment

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor originating from glial cells, characterized by high recurrence rates poor patient prognosis. The heterogeneity complex biology of GBM, coupled with the protective nature blood–brain barrier (BBB), significantly limit efficacy traditional therapies. rapid development nanoenzyme technology presents promising therapeutic paradigm for rational targeted treatment GBM. In this review, underlying mechanisms GBM pathogenesis are comprehensively discussed, emphasizing impact BBB on strategies. Recent advances in nanoenzyme‐based approaches therapy explored, highlighting how these nanoenzymes enhance various modalities through their multifunctional capabilities potential precise drug delivery. Finally, challenges prospects translating laboratory research to clinical application, including issues stability, targeting efficiency, safety, regulatory hurdles critically analyzed. By providing thorough understanding both opportunities obstacles associated therapies, future directions aimed be informed contribute more effective treatments

Язык: Английский

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Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 8 - 8

Опубликована: Янв. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Язык: Английский

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Advances in metal-organic framework-based drug delivery systems

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125380 - 125380

Опубликована: Фев. 1, 2025

Язык: Английский

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Nanomedicines for the treatment of ischemic stroke: an overview of recent advances

Precision medicine and engineering., Год журнала: 2025, Номер unknown, С. 100022 - 100022

Опубликована: Фев. 1, 2025

Язык: Английский

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Protein-based nano delivery systems focusing on protein materials, fabrication strategies and applications in ischemic stroke intervention: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 311, С. 143645 - 143645

Опубликована: Апрель 29, 2025

Язык: Английский

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Salidroside-Loaded Metal-organic Frameworks Hydrogel to Improve Cardiac Allograft Function

The Journal of Heart and Lung Transplantation, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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