ACS Nano,
Год журнала:
2020,
Номер
14(6), С. 6470 - 6497
Опубликована: Май 22, 2020
As
a
class
of
carbon-based
nanomaterials,
carbon
dots
(CDs)
have
attracted
enormous
attention
because
their
tunable
optical
and
physicochemical
properties,
such
as
absorptivity
photoluminescence
from
ultraviolet
to
near-infrared,
high
photostability,
biocompatibility,
aqueous
dispersity.
These
characteristics
make
CDs
promising
alternative
photonic
nanoagent
conventional
fluorophores
in
disease
diagnosis,
treatment,
healthcare
managements.
This
review
describes
the
fundamental
photophysical
properties
highlights
recent
applications
bioimaging,
photomedicine
(e.g.,
photodynamic/photothermal
therapies),
biosensors,
devices.
We
discuss
current
challenges
future
prospects
give
an
insight
into
developing
vibrant
fields
CD-based
biomedicine
healthcare.
Nanoscale Horizons,
Год журнала:
2019,
Номер
5(2), С. 218 - 234
Опубликована: Окт. 16, 2019
This
review
summarized
recent
advances
in
CDs-based
bioimaging
including
in
vitro
imaging
delivering
CDs
into
different
types
of
cells
and
vivo
applications
distribution
uptake
CDs,
imaging-guild
drug
delivery
tumor
therapeutics.
Advanced Functional Materials,
Год журнала:
2019,
Номер
29(25)
Опубликована: Апрель 22, 2019
Abstract
Reactive
oxygen
species
(ROS)‐based
cancer
therapy,
such
as
photodynamic
therapy
(PDT),
is
subject
to
the
hypoxia
and
overexpressed
glutathione
(GSH)
found
in
tumor
microenvironment
(TME).
Herein,
a
novel
strategy
reported
continuously
simultaneously
regulate
reducibility
order
achieve
desired
therapeutic
effect.
To
accomplish
this,
biocompatible
nanoplatform
(MnFe
2
O
4
@metal–organic
framework
(MOF))
developed
by
integrating
coating
of
porphyrin‐based
MOF
photosensitizer
manganese
ferrite
nanoparticle
)
nanoenzyme.
The
synthetic
MnFe
@MOF
exhibits
both
catalase‐like
peroxidase‐like
activities.
Once
internalized
tumor,
can
catalyze
H
produce
overcome
cyclic
Fenton
reaction.
Meanwhile,
combined
with
reaction,
able
persistently
consume
GSH
presence
,
which
decreases
depletion
ROS
upon
laser
irradiation
during
PDT
achieves
better
efficacy
vitro
vivo.
Moreover,
integrates
treatment
modality
magnetic
resonance
imaging,
along
persistent
regulation
TME,
promote
more
precise
effective
for
future
clinical
application.
ACS Nano,
Год журнала:
2020,
Номер
14(6), С. 6470 - 6497
Опубликована: Май 22, 2020
As
a
class
of
carbon-based
nanomaterials,
carbon
dots
(CDs)
have
attracted
enormous
attention
because
their
tunable
optical
and
physicochemical
properties,
such
as
absorptivity
photoluminescence
from
ultraviolet
to
near-infrared,
high
photostability,
biocompatibility,
aqueous
dispersity.
These
characteristics
make
CDs
promising
alternative
photonic
nanoagent
conventional
fluorophores
in
disease
diagnosis,
treatment,
healthcare
managements.
This
review
describes
the
fundamental
photophysical
properties
highlights
recent
applications
bioimaging,
photomedicine
(e.g.,
photodynamic/photothermal
therapies),
biosensors,
devices.
We
discuss
current
challenges
future
prospects
give
an
insight
into
developing
vibrant
fields
CD-based
biomedicine
healthcare.
