Translational Applications of Hydrogels

Chemical Reviews, Год журнала: 2021, Номер 121(18), С. 11385 - 11457

Опубликована: Май 3, 2021

Advances in hydrogel technology have unlocked unique and valuable capabilities that are being applied to a diverse set of translational applications. Hydrogels perform functions relevant range biomedical purposes-they can deliver drugs or cells, regenerate hard soft tissues, adhere wet prevent bleeding, provide contrast during imaging, protect tissues organs radiotherapy, improve the biocompatibility medical implants. These make hydrogels useful for many distinct pressing diseases conditions even less conventional areas such as environmental engineering. In this review, we cover major hydrogels, with focus on novel benefits injectable how they relate applications medicine environment. We pay close attention development contemporary requires extensive interdisciplinary collaboration accomplish highly specific complex biological tasks from cancer immunotherapy tissue engineering vaccination. complement our discussion preclinical clinical mechanical design considerations needed scaling technologies application. anticipate readers will gain more complete picture expansive possibilities practical impactful differences across numerous fields

Язык: Английский

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Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

Bioactive Materials, Год журнала: 2021, Номер 8, С. 267 - 295

Опубликована: Июль 6, 2021

Polymeric hydrogels are fascinating platforms as 3D scaffolds for tissue repair and delivery systems of therapeutic molecules cells. Among others, methacrylated gelatin (GelMA) has become a representative hydrogel formulation, finding various biomedical applications. Recent efforts on GelMA-based have been devoted to combining them with bioactive functional nanomaterials, aiming provide enhanced physicochemical biological properties GelMA. The benefits this approach multiple: i) reinforcing mechanical properties, ii) modulating viscoelastic property allow printability bio-inks, iii) rendering electrical/magnetic produce electro-/magneto-active the specific tissues (e.g., muscle, nerve), iv) providing stimuli-responsiveness actively deliver molecules, v) endowing capacity in process antioxidant effects). nanomaterial-combined GelMA shown significantly extraordinary behaviors (bone, skin, cardiac, nerve) that rarely observable Here we systematically review these recent nanomaterials-combined considered next-generation multifunctional therapeutics. approaches used can also apply other existing polymeric systems.

Язык: Английский

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Supramolecular engineering of hydrogels for drug delivery

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 171, С. 240 - 256

Опубликована: Фев. 7, 2021

Supramolecular binding motifs are increasingly employed in the design of biomaterials. The ability to rationally engineer specific yet reversible associations into polymer networks with supramolecular chemistry enables injectable or sprayable hydrogels that can be applied via minimally invasive administration. In this review, we highlight two main areas where being used drug delivery systems: engineering network mechanics and tailoring drug–material affinity. Throughout, many established emerging chemistries useful for applications.

Язык: Английский

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Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1415 - 1415

Опубликована: Янв. 26, 2022

Hydrogels from biopolymers are readily synthesized, can possess various characteristics for different applications, and have been widely used in biomedicine to help with patient treatments outcomes. Polysaccharides, polypeptides, nucleic acids be produced into hydrogels, each unique purposes depending on their qualities. Examples of polypeptide hydrogels include collagen, gelatin, elastin, polysaccharide alginate, cellulose, glycosaminoglycan. Many theories formulated research which Flory-Rehner theory, Rubber Elasticity Theory, the calculation porosity pore size. All these take consideration enthalpy, entropy, other thermodynamic variables so that structure sizes formulated. fabricated a straightforward process using homogeneous mixture chemicals, intended purpose gel. Different types exist pH-sensitive gels, thermogels, electro-sensitive light-sensitive gels has its biomedical applications including structural capabilities, regenerative repair, or drug delivery. Major biopolymer-based cell delivery encapsulated skeletal muscle cells, osteochondral stem cells being delivered desired locations tissue regeneration. Some examples biomolecule insulin encompass cancer drugs controlled release. This review summarizes newly developed hydrogel materials mainly made since 2015 shown work present more avenues advanced medical applications.

Язык: Английский

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Bioengineered nanogels for cancer immunotherapy

Chemical Society Reviews, Год журнала: 2022, Номер 51(12), С. 5136 - 5174

Опубликована: Янв. 1, 2022

Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as multipurpose and constructed vectors formed via intramolecular cross-linking to generate drug delivery systems, which is attributed predominantly their satisfactory biocompatibility, bio-responsiveness, high stability, low toxicity. Recently, immunotherapy has experienced unprecedented growth become the preferred strategy cancer treatment, mainly involves mobilisation of immune system an enhanced anti-tumour immunity tumour microenvironment. Despite inspiring success, immunotherapeutic strategies are limited due response rates immune-related adverse events. Like other nanomedicines, nanogels comparably by lower focal enrichment upon introduction into organism injection. Because three-dimensional cross-linked aqueous materials that exhibit similar properties natural tissues structurally stable, they can comfortably cope with shear forces serum proteins bloodstream, longer circulation life increases chance nanogel accumulation tumour, conferring deep penetration. The large specific surface area reduce or eliminate off-target effects introducing stimuli-responsive functional groups, allowing multiple physical chemical modifications purposes improve targeting cell subpopulations organs, increasing bioavailability drug, a events on therapies. slow release reaching site facilitates long-term awakening host's system, ultimately achieving therapeutic effects. As effective candidate immunotherapy, nanogel-based been widely used. In this review, we summarize recent deliver immunomodulatory small molecule drugs, antibodies, genes cytokines, target antigen presenting cells, form vaccines, enable chimeric receptor (CAR)-T therapy. Future challenges well expected feasible prospects clinical also highlighted.

Язык: Английский

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Current and Future Prospective of Injectable Hydrogels—Design Challenges and Limitations

Pharmaceuticals, Год журнала: 2022, Номер 15(3), С. 371 - 371

Опубликована: Март 18, 2022

Injectable hydrogels (IHs) are smart biomaterials and the most widely investigated versatile technologies, which can be either implanted or inserted into living bodies with minimal invasion. Their unique features, tunable structure stimuli-responsive biodegradation properties make these IHs promising in many biomedical applications, including tissue engineering, regenerative medicines, implants, drug/protein/gene delivery, cancer treatment, aesthetic corrections spinal fusions. In this review, we comprehensively analyze current development of several important types IHs, all those that have received FDA approval, under clinical trials available commercially on market. We also structural chemistry, synthesis, bonding, chemical/physical crosslinking responsive release association prospective research. Finally, review IHs' associated future prospects, hurdles, limitations challenges their development, fabrication, situ applications regulatory affairs.

Язык: Английский

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Biopolymers based aerogels: A review on revolutionary solutions for smart therapeutics delivery

Progress in Materials Science, Год журнала: 2022, Номер 131, С. 101014 - 101014

Опубликована: Авг. 31, 2022

Язык: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Язык: Английский

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Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases

Advanced Materials, Год журнала: 2022, Номер 34(16)

Опубликована: Фев. 23, 2022

Functional hydrogels responsive to physiological and pathological signals have extensive biomedical applications owing their multiple advanced attributes. Herein, engineering of functional is reported via transformable nanoparticles in response the physiologically pathologically acidic microenvironment. These are assembled by a multivalent hydrophobic, pH-responsive cyclodextrin host material hydrophilic guest macromolecule. Driven protons, host-guest can be transformed into hydrogel, resulting from proton-triggered hydrolysis material, generation compound, simultaneously enhanced inclusion interactions between molecules. By situ forming hydrogel barrier, orally delivered protect mice ethanol- or drug-induced gastric injury. In addition, this type serve as nanovehicles for therapeutic agents achieve triggerable sustained drug delivery, thereby effectively treating typical inflammatory diseases, including periodontitis arthritis rats. With combined advantages hydrogels, together with good vivo safety, engineered hold great promise tissue injury protection site-specific/local delivery molecular cellular agents.

Язык: Английский

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