Advanced Science, Год журнала: 2023, Номер 10(7)
Опубликована: Янв. 16, 2023
High levels of reactive oxygen species (ROS) and inflammation create a complicated extrinsic neural environment that dominates the initial post-injury period after spinal cord injury (SCI). The compensatory pathways between ROS limited efficacy modulating above single treatment regimen SCI. Here, novel "nanoflower" Mn
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Май 25, 2023
Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.
Язык: Английский
Процитировано
658
Advanced Materials, Год журнала: 2020, Номер 33(4)
Опубликована: Дек. 4, 2020
Abstract Micro‐/nanorobots (m‐bots) have attracted significant interest due to their suitability for applications in biomedical engineering and environmental remediation. Particularly, vivo diagnosis intervention been the focus of extensive research recent years with various clinical imaging techniques being applied localization tracking. The successful integration well‐designed m‐bots surface functionalization, remote actuation systems, becomes crucial step toward applications, especially uses. This review thus addresses four different aspects m‐bots: design/fabrication, actuation, localization. diagnosis, sensing, microsurgery, targeted drug/cell delivery, thrombus ablation, wound healing are reviewed from these viewpoints. developed m‐bot systems comprehensively compared evaluated based on characteristics. current challenges directions future this field summarized.
Язык: Английский
Процитировано
389
Science Robotics, Год журнала: 2021, Номер 6(52)
Опубликована: Март 17, 2021
A neutrophil-hybrid microrobot is capable of active accumulation close to the brain and penetration across blood-brain barrier.
Язык: Английский
Процитировано
367
Nature Communications, Год журнала: 2020, Номер 11(1)
Опубликована: Ноя. 5, 2020
Abstract Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and severe side effects it can cause, numerous nanomedicine approaches have been developed overcome these issues. However, targeted delivery therapeutics challenging. Engineering microrobots is increasingly receiving attention in this regard. Their functionalities, particularly their motility, allow penetrate tissues reach cancers more efficiently. Here, we highlight how different microrobots, ranging from tailor-made motile bacteria tiny bubble-propelled microengines hybrid spermbots, be engineered integrate sophisticated features optimised for precision-targeting a wide range cancers. Towards this, importance integrating clinicians, public patients early on development novel technologies.
Язык: Английский
Процитировано
342
Nature Communications, Год журнала: 2020, Номер 11(1)
Опубликована: Фев. 28, 2020
Abstract The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), well vascular and interstitial barriers. To overcome abovementioned obstacles, we report a nano-pathogenoid (NPN) that can in situ hitchhike circulating neutrophils supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogen-associated molecular patterns native bacteria, NPNs are effectively recognized internalized neutrophils. migrate towards inflamed tumors, extravasate across blood vessels, penetrate through tumors. Then rapidly released from response to inflammatory stimuli subsequently taken up tumor cells exert anticancer effects. Strikingly, due excellent targeting efficacy, cisplatin-loaded combined PTT completely eradicate tumors all treated mice. Such nano-platform represents an efficient generalizable strategy cell hitchhiking enhanced targeted delivery.
Язык: Английский
Процитировано
245
Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)
Опубликована: Июнь 7, 2021
Abstract Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs) since rise of targeted drug delivery systems and nanotechnology. Biological vectors including cell membranes, extracellular vesicles (EVs), viruses are considered promising candidates for owing their biocompatibility biodegradability. BNPs, integration biological functional agents, anticipated load cargos or camouflage synthetic achieve delivery. Despite excellent intrinsic properties, natural deliberately modified endow multiple functions such as good permeability, improved loading capability, high specificity. Through structural modification transformation vectors, they pervasively utilized more effective vehicles that can deliver contrast chemotherapy drugs, nucleic acids, genes target sites refractory disease therapy. This review summarizes recent advances in based on EVs, viruses, highlighting potential applications BNPs fields biomedical imaging therapy industry, well discussing possibility clinical translation exploitation trend these BNPs.
Язык: Английский
Процитировано
233
Advanced Science, Год журнала: 2019, Номер 6(15)
Опубликована: Май 22, 2019
Abstract Inflammation is ubiquitous in the body, triggering desirable immune response to defend against dangerous signals or instigating undesirable damage cells and tissues cause disease. Nanomedicine holds exciting potential modulating inflammation. In particular, cell membranes derived from involved inflammatory process may be used coat nanotherapeutics for effective targeted delivery tissues. Herein, recent progress of rationally engineering membrane‐based inflammation therapy highlighted, challenges opportunities presented realizing full cell‐membrane coating targeting manipulating microenvironment are discussed.
Язык: Английский
Процитировано
210
Science Advances, Год журнала: 2022, Номер 8(2)
Опубликована: Янв. 12, 2022
Neutrophil-derived exosomes induce tumor cell apoptosis by delivering cytotoxic proteins and activating caspase signaling pathway.
Язык: Английский
Процитировано
185
Current Opinion in Biotechnology, Год журнала: 2018, Номер 58, С. 81 - 91
Опубликована: Дек. 5, 2018
Язык: Английский
Процитировано
179
Frontiers in Bioengineering and Biotechnology, Год журнала: 2023, Номер 11
Опубликована: Апрель 13, 2023
Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due their unique physicochemical biological properties. By combining with nanoparticles using rational targeting pathways, nano-targeted were created overcome main drawbacks conventional treatment, including insufficient stability solubility, lack transmembrane transport, short circulation time, undesirable toxic effects. Herein, we reviewed recent developments in different design strategies approaches employing various nanomaterial-based systems. We also discussed challenges perspectives smart precisely intravascular extravascular diseases.
Язык: Английский
Процитировано
177