Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(22)
Published: March 9, 2024
Abstract
The
precise
targeted
delivery
of
therapeutic
agents
to
deep
regions
the
brain
is
crucial
for
effective
treatment
various
neurological
diseases.
However,
achieving
this
goal
challenging
due
presence
blood‒brain
barrier
(BBB)
and
complex
anatomy
brain.
Here,
a
biomimetic
self‐propelled
nanomotor
with
cascade
targeting
capacity
developed
inflammatory
nanomotors
are
designed
asymmetric
structures
mesoporous
SiO
2
head
multiple
MnO
tentacles.
Macrophage
membrane
modification
endows
BBB
penetration
abilities
catalyze
degradation
H
O
into
,
not
only
by
reducing
inflammation
but
also
providing
driving
force
penetration.
Additionally,
loaded
curcumin,
which
actively
regulates
macrophage
polarization
from
M1
M2
phenotype.
All
in
vitro
cell,
organoid
model,
vivo
animal
experiments
confirmed
effectiveness
targeting,
penetration,
anti‐inflammatory,
nervous
system
function
maintenance.
Therefore,
study
introduces
platform
ability
active
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 25, 2023
Abstract
Blood–brain
barrier
(BBB)
is
a
natural
protective
membrane
that
prevents
central
nervous
system
(CNS)
from
toxins
and
pathogens
in
blood.
However,
the
presence
of
BBB
complicates
pharmacotherapy
for
CNS
disorders
as
most
chemical
drugs
biopharmaceuticals
have
been
impeded
to
enter
brain.
Insufficient
drug
delivery
into
brain
leads
low
therapeutic
efficacy
well
aggravated
side
effects
due
accumulation
other
organs
tissues.
Recent
breakthrough
materials
science
nanotechnology
provides
library
advanced
with
customized
structure
property
serving
powerful
toolkit
targeted
delivery.
In-depth
research
field
anatomical
pathological
study
on
further
facilitates
development
brain-targeted
strategies
enhanced
crossing.
In
this
review,
physiological
different
cells
contributing
are
summarized.
Various
emerging
permeability
regulation
crossing
including
passive
transcytosis,
intranasal
administration,
ligands
conjugation,
coating,
stimuli-triggered
disruption,
overcome
obstacle
highlighted.
Versatile
systems
ranging
organic,
inorganic,
biologics-derived
their
synthesis
procedures
unique
physio-chemical
properties
summarized
analyzed.
This
review
aims
provide
an
up-to-date
comprehensive
guideline
researchers
diverse
fields,
offering
perspectives
system.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
33(4)
Published: Dec. 4, 2020
Abstract
Micro‐/nanorobots
(m‐bots)
have
attracted
significant
interest
due
to
their
suitability
for
applications
in
biomedical
engineering
and
environmental
remediation.
Particularly,
vivo
diagnosis
intervention
been
the
focus
of
extensive
research
recent
years
with
various
clinical
imaging
techniques
being
applied
localization
tracking.
The
successful
integration
well‐designed
m‐bots
surface
functionalization,
remote
actuation
systems,
becomes
crucial
step
toward
applications,
especially
uses.
This
review
thus
addresses
four
different
aspects
m‐bots:
design/fabrication,
actuation,
localization.
diagnosis,
sensing,
microsurgery,
targeted
drug/cell
delivery,
thrombus
ablation,
wound
healing
are
reviewed
from
these
viewpoints.
developed
m‐bot
systems
comprehensively
compared
evaluated
based
on
characteristics.
current
challenges
directions
future
this
field
summarized.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Nov. 5, 2020
Abstract
Systemic
chemotherapy
remains
the
backbone
of
many
cancer
treatments.
Due
to
its
untargeted
nature
and
severe
side
effects
it
can
cause,
numerous
nanomedicine
approaches
have
been
developed
overcome
these
issues.
However,
targeted
delivery
therapeutics
challenging.
Engineering
microrobots
is
increasingly
receiving
attention
in
this
regard.
Their
functionalities,
particularly
their
motility,
allow
penetrate
tissues
reach
cancers
more
efficiently.
Here,
we
highlight
how
different
microrobots,
ranging
from
tailor-made
motile
bacteria
tiny
bubble-propelled
microengines
hybrid
spermbots,
be
engineered
integrate
sophisticated
features
optimised
for
precision-targeting
a
wide
range
cancers.
Towards
this,
importance
integrating
clinicians,
public
patients
early
on
development
novel
technologies.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Feb. 28, 2020
Abstract
The
efficacy
of
nano-mediated
drug
delivery
has
been
impeded
by
multiple
biological
barriers
such
as
the
mononuclear
phagocyte
system
(MPS),
well
vascular
and
interstitial
barriers.
To
overcome
abovementioned
obstacles,
we
report
a
nano-pathogenoid
(NPN)
that
can
in
situ
hitchhike
circulating
neutrophils
supplement
photothermal
therapy
(PTT).
Cloaked
with
bacteria-secreted
outer
membrane
vesicles
inheriting
pathogen-associated
molecular
patterns
native
bacteria,
NPNs
are
effectively
recognized
internalized
neutrophils.
migrate
towards
inflamed
tumors,
extravasate
across
blood
vessels,
penetrate
through
tumors.
Then
rapidly
released
from
response
to
inflammatory
stimuli
subsequently
taken
up
tumor
cells
exert
anticancer
effects.
Strikingly,
due
excellent
targeting
efficacy,
cisplatin-loaded
combined
PTT
completely
eradicate
tumors
all
treated
mice.
Such
nano-platform
represents
an
efficient
generalizable
strategy
cell
hitchhiking
enhanced
targeted
delivery.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: June 7, 2021
Abstract
Over
the
past
decades,
great
interest
has
been
given
to
biomimetic
nanoparticles
(BNPs)
since
rise
of
targeted
drug
delivery
systems
and
nanotechnology.
Biological
vectors
including
cell
membranes,
extracellular
vesicles
(EVs),
viruses
are
considered
promising
candidates
for
owing
their
biocompatibility
biodegradability.
BNPs,
integration
biological
functional
agents,
anticipated
load
cargos
or
camouflage
synthetic
achieve
delivery.
Despite
excellent
intrinsic
properties,
natural
deliberately
modified
endow
multiple
functions
such
as
good
permeability,
improved
loading
capability,
high
specificity.
Through
structural
modification
transformation
vectors,
they
pervasively
utilized
more
effective
vehicles
that
can
deliver
contrast
chemotherapy
drugs,
nucleic
acids,
genes
target
sites
refractory
disease
therapy.
This
review
summarizes
recent
advances
in
based
on
EVs,
viruses,
highlighting
potential
applications
BNPs
fields
biomedical
imaging
therapy
industry,
well
discussing
possibility
clinical
translation
exploitation
trend
these
BNPs.
Advanced Science,
Journal Year:
2019,
Volume and Issue:
6(15)
Published: May 22, 2019
Abstract
Inflammation
is
ubiquitous
in
the
body,
triggering
desirable
immune
response
to
defend
against
dangerous
signals
or
instigating
undesirable
damage
cells
and
tissues
cause
disease.
Nanomedicine
holds
exciting
potential
modulating
inflammation.
In
particular,
cell
membranes
derived
from
involved
inflammatory
process
may
be
used
coat
nanotherapeutics
for
effective
targeted
delivery
tissues.
Herein,
recent
progress
of
rationally
engineering
membrane‐based
inflammation
therapy
highlighted,
challenges
opportunities
presented
realizing
full
cell‐membrane
coating
targeting
manipulating
microenvironment
are
discussed.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2019,
Volume and Issue:
11(5)
Published: May 6, 2019
Abstract
Photodynamic
therapy
(PDT)
is
a
treatment
by
combining
light
and
photosensitizer
to
generate
reactive
oxygen
species
(ROS)
for
cellular
damage,
used
treat
cancer
infectious
diseases.
In
this
review,
we
focus
on
recent
advances
in
design
of
new
photosensitizers
increased
production
ROS
genetic
engineering
biological
study
signaling
pathways.
A
concept
has
been
proposed
that
PDT‐induced
acute
inflammation
can
mediate
neutrophil
infiltration
deliver
therapeutics
deep
tumor
tissues.
Combination
PDT
immunotherapies
(neutrophil‐mediated
therapeutic
delivery)
shown
the
promising
translation
therapies.
Furthermore,
area
bacterial
infections
overcome
antimicrobial
resistance.
Finally,
have
discussed
directions
therapies
summary,
believe
rational
innovations
nanomaterials
may
great
impact
This
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Nanomedicine
Oncologic
Disease
Infectious
Nanotechnology
Biology
Nanoscale
Systems
