Polymeric Tissue Adhesives

Chemical Reviews, Год журнала: 2021, Номер 121(18), С. 11336 - 11384

Опубликована: Янв. 28, 2021

Polymeric tissue adhesives provide versatile materials for wound management and are widely used in a variety of medical settings ranging from minor to life-threatening injuries. Compared the traditional methods closure (i.e., suturing stapling), they relatively easy use, enable rapid application, introduce minimal damage. Furthermore, can act as hemostats control bleeding tissue-healing environment at site. Despite their numerous current applications, still face several limitations unresolved challenges (e.g., weak adhesion strength poor mechanical properties) that limit leaving ample room future improvements. Successful development next-generation will likely require holistic understanding chemical physical properties tissue-adhesive interface, fundamental mechanisms adhesion, requirements specific clinical applications. In this review, we discuss set rational guidelines design adhesives, recent progress field along with examples commercially available those under development, tissue-specific considerations, finally potential functions adhesives. Advances open new avenues care potentially potent therapeutics various

Язык: Английский

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Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Biomolecules, Год журнала: 2019, Номер 9(9), С. 470 - 470

Опубликована: Сен. 10, 2019

Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, is unique natural polysaccharide with outstanding properties in line excellent biodegradability, biocompatibility, and antimicrobial activity. Due to presence of free amine groups its backbone chain, could be further chemically modified possess additional functional useful development different biomaterials regenerative medicine. In current review, we will highlight progress made chitosan-containing bioscaffolds, such as gels, sponges, films, fibers, their possible applications repair regeneration, well use component drug delivery

Язык: Английский

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Breakthrough treatments for accelerated wound healing

Science Advances, Год журнала: 2023, Номер 9(20)

Опубликована: Май 17, 2023

Skin injuries across the body continue to disrupt everyday life for millions of patients and result in prolonged hospital stays, infection, death. Advances wound healing devices have improved clinical practice but mainly focused on treating macroscale versus underlying microscale pathophysiology. Consensus is lacking optimal treatment strategies using a spectrum products, which has motivated design new therapies. We summarize advances development novel drug, biologic biomaterial therapies marketed those trials. also share perspectives successful accelerated translation integrated healing.

Язык: Английский

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Multifaceted Design and Emerging Applications of Tissue Adhesives

Advanced Materials, Год журнала: 2021, Номер 33(24)

Опубликована: Май 6, 2021

Abstract Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in a variety of medical settings such as wound closure, surgical sealants, regenerative medicine, device attachment. The advantages tissue include ease implementation, rapid application, mitigation damage, compatibility minimally invasive procedures. field is rapidly evolving, leading to superior mechanical properties advanced functionality. Such enable new applications ranging from mobile health cancer treatment. To provide guidelines for the rational design adhesives, here, existing strategies are synthesized into multifaceted design, which comprises three elements: tissue, adhesive surface, matrix. mechanical, chemical, biological considerations associated each element reviewed. Throughout report, limitations immediate opportunities improvement discussed. recent progress topical implantable highlighted, then future directions toward next‐generation outlined. development will fuse disciplines make broad impacts engineering medicine.

Язык: Английский

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Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity

Nature Biomedical Engineering, Год журнала: 2022, Номер 6(10), С. 1167 - 1179

Опубликована: Янв. 3, 2022

Язык: Английский

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3D bioprinting dual-factor releasing and gradient-structured constructs ready to implant for anisotropic cartilage regeneration

Science Advances, Год журнала: 2020, Номер 6(37)

Опубликована: Сен. 9, 2020

3D bioprinting helps to reconstruct your broken knee.

Язык: Английский

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Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing

Advanced Healthcare Materials, Год журнала: 2020, Номер 9(11)

Опубликована: Апрель 27, 2020

Abstract Current standard of care dressings are unsatisfactorily inefficacious for the treatment chronic wounds. Chronic inflammation is primary cause long‐term incurable nature Herein, an absorbable nanofibrous hydrogel developed synergistic modulation microenvironment to accelerate diabetic wound healing. The electrospun thioether grafted hyaluronic acid nanofibers (FHHA‐S/Fe) able form a in situ on bed. This degrades and absorbed gradually within 3 days. thioethers HHA can scavenge reactive oxygen species quickly early phase relieve reactions. Additionally, itself promote transformation gathered M1 macrophages M2 phenotype, thus synergistically accelerating healing transition from proliferation remodeling. On model, average remaining area after FHHA‐S/Fe much smaller than both that FHHA/Fe without control group, especially stage. Therefore, this facile dressing strategy with intrinsic dual mechanisms may act as effective safe management.

Язык: Английский

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Degradable and Removable Tough Adhesive Hydrogels

Advanced Materials, Год журнала: 2021, Номер 33(17)

Опубликована: Март 24, 2021

The development of tough adhesive hydrogels has enabled unprecedented adhesion to wet and moving tissue surfaces throughout the body, but they are typically composed nondegradable components. Here, a family degradable containing ≈90% water by incorporating covalently networked crosslinkers hydrolyzable ionically crosslinked main‐chain polymers is developed. Mechanical toughness, adhesion, degradation these new formulations tested in both accelerated vitro conditions up 16 weeks vivo. These adhesives engineered with equivalent mechanical properties adhesives, capable achieving stretches >20 times their initial length, fracture energies >6 kJ m −2 , >1000 J . All systems show complete within 2 under aging months vivo depending on crosslinker selected. Excellent biocompatibility observed for all groups after 1, 2, 4, 8, implantation, minimal fibrous encapsulation no signs organ toxicity. On‐demand removal achieved treatment chemical agents which do not cause damage underlying skin mice. broad versatility this provides foundation numerous indications.

Язык: Английский

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A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Advanced Materials, Год журнала: 2022, Номер 35(5)

Опубликована: Ноя. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Язык: Английский

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Hydroxyapatite: A journey from biomaterials to advanced functional materials

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 321, С. 103013 - 103013

Опубликована: Окт. 7, 2023

Hydroxyapatite (HAp), a well-known biomaterial, has witnessed remarkable evolution over the years, transforming from simple biocompatible substance to an advanced functional material with wide range of applications. This abstract provides overview significant advancements in field HAp and its journey towards becoming multifunctional material. Initially recognized for exceptional biocompatibility bioactivity, gained prominence bone tissue engineering dental Its ability integrate surrounding tissues, promote cellular adhesion, facilitate osseointegration made it ideal candidate various biomedical implants coatings. As understanding grew, researchers explored potential beyond traditional biomaterial With advances synthesis engineering, began exhibit unique properties that extended utility other disciplines. Researchers successfully tailored composition, morphology, surface characteristics HAp, leading enhanced mechanical strength, controlled drug release capabilities, improved biodegradability. These modifications enabled utilization delivery systems, biosensors, scaffolds, regenerative medicine Moreover, biomineralization allowed incorporation ions molecules during synthesis, development bioactive coatings composites specific therapeutic functionalities. functionalized materials have demonstrated promising results antimicrobial coatings, systems growth factors agents, even as catalysts chemical reactions. In recent nanoparticles nanostructured emerged focal point research due their physicochemical targeted delivery, imaging, theranostic The manipulate size, shape, chemistry at nanoscale paved way innovative approaches personalized therapies. highlights exploration novel methods, modifications, nanoengineering techniques expanded horizon applications, enabling integration into diverse fields ranging biomedicine catalysis. Additionally, this manuscript discusses emerging prospects HAp-based photocatalysis, sensing, energy storage, showcasing realm progresses, future holds tremendous revolutionize medical treatments contribute advancement science technology.

Язык: Английский

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