Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)

Опубликована: Дек. 16, 2021

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) influence cell signaling cascades fate. In the past few decades, plethora pioneering studies have been implemented explore cell-hydrogel matrix interactions figure out underlying mechanisms, paving way lab-to-clinic translation hydrogel-based therapies. this review, we first introduced hydrogels their fabrication approaches concisely. Subsequently, comprehensive description deep discussion were elucidated, wherein influences different behaviors cellular events highlighted. These or included integrin clustering, focal adhesion (FA) complex accumulation activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling activation Yes-associated (YAP), catenin, etc.), compartment reorganization, gene expression, further biology modulation spreading, migration, proliferation, lineage commitment, etc.). Based them, current in vitro vivo hydrogel mainly covered diseases models, delivery protocols for tissue regeneration disease therapy, smart drug carrier, bioimaging, biosensor, conductive wearable/implantable biodevices, etc. summarized discussed. More significantly, clinical potential trials presented, accompanied which remaining challenges future perspectives field emphasized. Collectively, insights review will shed light principles new understand processes, are available providing significant indications serving broad range applications.

Язык: Английский

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Unraveling of Advances in 3D-Printed Polymer-Based Bone Scaffolds

Polymers, Год журнала: 2022, Номер 14(3), С. 566 - 566

Опубликована: Янв. 30, 2022

The repair of large-area irregular bone defects is one the complex problems in orthopedic clinical treatment. scaffolds currently studied include electrospun membrane, hydrogel, cement, 3D printed tissue scaffolds, etc., among which polymer-based Bone are most promising for applications. This because printing modeled based on im-aging results actual so that can perfectly fit defect, and components be adjusted to promote Osteogenesis. review introduces a variety technologies healing processes, reviews previous studies characteristics commonly used natural or synthetic polymers, applications analyzes elaborates ideal from t he progress were summarized many aspects. challenges potential prospects this direction discussed.

Язык: Английский

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Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation

Biomaterials, Год журнала: 2022, Номер 285, С. 121538 - 121538

Опубликована: Апрель 25, 2022

Язык: Английский

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Soft Bioelectronics Based on Nanomaterials

Chemical Reviews, Год журнала: 2021, Номер 122(5), С. 5068 - 5143

Опубликована: Дек. 28, 2021

Recent advances in nanostructured materials and unconventional device designs have transformed the bioelectronics from a rigid bulky form into soft ultrathin brought enormous advantages to bioelectronics. For example, mechanical deformability of thus its conformal contact onto curved organs such as brain, heart, skin allowed researchers measure high-quality biosignals, deliver real-time feedback treatments, lower long-term side-effects vivo. Here, we review various materials, fabrication methods, strategies for flexible stretchable electronics, especially focusing on biointegrated electronics using nanomaterials their composites. First, summarize top-down material processing bottom-up synthesis methods nanomaterials. Next, discuss state-of-the-art technologies intrinsically nanocomposites composed incorporated elastomers or hydrogels. We also briefly design Then individual components bioelectronics, biosensing, data storage, display, therapeutic stimulation, power supply devices, are introduced. Afterward, representative application examples described. A brief summary with discussion remaining challenges concludes review.

Язык: Английский

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3D Bioprinted cancer models: Revolutionizing personalized cancer therapy

Translational Oncology, Год журнала: 2021, Номер 14(4), С. 101015 - 101015

Опубликована: Янв. 22, 2021

After cardiovascular disease, cancer is the leading cause of death worldwide with devastating health and economic consequences, particularly in developing countries. Inter-patient variations anti-cancer drug responses further limit success therapeutic interventions. Therefore, personalized medicines approach key for this patient group involving molecular genetic screening appropriate stratification patients to treatment regimen that they will respond to. However, knowledge related adequate risk methods identifying who specific agents still lacking many types. Recent advancements three-dimensional (3D) bioprinting technology, have been extensively used generate representative bioengineered tumor vitro models, which recapitulate human tissues microenvironment high-throughput screening. Bioprinting process involves precise deposition multiple layers different cell types combination biomaterials capable generating 3D based on a computer-aided design. Bioprinted models containing patient-derived stromal cells together material, extracellular matrix proteins growth factors, represent promising therapy Both natural synthetic biopolymers utilized support proliferation biological material within models/implants. These can provide physiologically pertinent cell–cell cell–matrix interactions by mimicking heterogeneity real tumors. Here, we reviewed potential applications bioprinted constructs as anticancer establishment precision regimens.

Язык: Английский

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Digital Light Processing Based Bioprinting with Composable Gradients

Advanced Materials, Год журнала: 2021, Номер 34(1)

Опубликована: Окт. 7, 2021

Recapitulation of complex tissues signifies a remarkable challenge and, to date, only few approaches have emerged that can efficiently reconstruct necessary gradients in 3D constructs. This is true even though mimicry these great importance establish the functionality engineered and devices. Here, composable-gradient Digital Light Processing (DLP)-based (bio)printing system developed, utilizing unprecedented integration microfluidic mixer for generation either continual or discrete desired (bio)inks real time. Notably, precisely controlled are composable on-the-fly by facilely adjusting (bio)ink flow ratios. In addition, this setup designed such way waste minimized when exchanging gradient (bio)inks, further enhancing time- (bio)ink-saving strategy. Various planar structures exhibiting materials, cell densities, growth factor concentrations, hydrogel stiffness, porosities horizontal and/or vertical direction, exemplified. The fabrication multifunctional strongly supports potential unique bioprinting numerous biomedical applications.

Язык: Английский

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3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model

Biomaterials, Год журнала: 2021, Номер 279, С. 121216 - 121216

Опубликована: Окт. 27, 2021

Язык: Английский

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Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare

Progress in Materials Science, Год журнала: 2023, Номер 134, С. 101072 - 101072

Опубликована: Янв. 16, 2023

Язык: Английский

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3D Printing Technologies in Personalized Medicine, Nanomedicines, and Biopharmaceuticals

Pharmaceutics, Год журнала: 2023, Номер 15(2), С. 313 - 313

Опубликована: Янв. 17, 2023

3D printing technologies enable medicine customization adapted to patients' needs. There are several techniques available, but majority of dosage forms and medical devices printed using nozzle-based extrusion, laser-writing systems, powder binder jetting. has been demonstrated for a broad range applications in development targeting solid, semi-solid, locally applied or implanted medicines. 3D-printed solid allow the combination one more drugs within same form improve patient compliance, facilitate deglutition, tailor release profile, fabricate new medicines which no is available. Sustained-release implants, stents, have used mainly joint replacement therapies, prostheses, cardiovascular applications. Locally medicines, such as wound dressing, microneedles, medicated contact lenses, also manufactured techniques. The challenge select technique most suitable each application type pharmaceutical ink that should be developed possesses required physicochemical biological performance. integration biopharmaceuticals nanotechnology-based along with ("nanoprinting") brings personalized nanomedicines innovative perspectives coming years. Continuous manufacturing through use microfluidic chips facilitates their translation into clinical practice.

Язык: Английский

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Bioinspired gradient scaffolds for osteochondral tissue engineering

Exploration, Год журнала: 2023, Номер 3(4)

Опубликована: Июль 12, 2023

Repairing articular osteochondral defects present considerable challenges in self-repair due to the complex tissue structure and low proliferation of chondrocytes. Conventional clinical therapies have not shown significant efficacy, including microfracture, autologous/allograft transplantation, cell-based techniques. Therefore, engineering has been widely explored repairing by leveraging natural regenerative potential biomaterials control cell functions. However, is a gradient with smooth transition from cartilage subchondral bone, involving changes chondrocyte morphologies phenotypes, extracellular matrix components, collagen type orientation, cytokines. Bioinspired scaffolds developed simulating characteristics heterogeneous tissues, such as pores, osteochondrogenesis-inducing factors, satisfy anisotropic features matrices. repair altering microenvironments growth induce osteochondrogenesis promote formation interfaces compared homogeneous scaffolds. This review outlines meaningful strategies for based on predicts pros cons prospective translation into practice.

Язык: Английский

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