Targeting drugs to tumours using cell membrane-coated nanoparticles

Nature Reviews Clinical Oncology, Год журнала: 2022, Номер 20(1), С. 33 - 48

Опубликована: Окт. 28, 2022

Язык: Английский

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Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Год журнала: 2022, Номер 9(22)

Опубликована: Июнь 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Язык: Английский

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Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small, Год журнала: 2021, Номер 17(12)

Опубликована: Фев. 12, 2021

Abstract Nanotechnology has provided great opportunities for managing neoplastic conditions at various levels, from preventive and diagnostic to therapeutic fields. However, when it comes clinical application, nanoparticles (NPs) have some limitations in terms of biological stability, poor targeting, rapid clearance the body. Therefore, biomimetic approaches, utilizing immune cell membranes, are proposed solve these issues. For example, macrophage or neutrophil membrane coated NPs developed with ability interact tumor tissue suppress cancer progression metastasis. The functionality particles largely depends on surface proteins cells their preserved function during extraction coating process NPs. Proteins outer can render a wide range activities NPs, including prolonged blood circulation, remarkable competency recognizing antigens enhanced better cellular interactions, gradual drug release, reduced toxicity vivo. In this review, nano‐based systems cells‐derived membranous layers, detailed production process, applicability treatment discussed. addition, future perspectives challenges translation also presented.

Язык: Английский

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Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Theranostics, Год журнала: 2021, Номер 12(1), С. 434 - 458

Опубликована: Дек. 15, 2021

Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to because of powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity tumors. Photodynamic therapy (PDT) can not only directly kill cells, but also elicit immunogenic cell death (ICD), providing antitumor immunity. Unfortunately, limitations from the inherent nature complex TME significantly reduce efficiency PDT. Recently, smart nanomedicine-based strategies could subtly modulate pharmacokinetics therapeutic compounds optimize both PDT immunotherapy, resulting an improved effect. Here, emerging nanomedicines for PDT-driven cancer are reviewed, including hypoxia-reversed nanomedicines, nanosized metal-organic frameworks, subcellular targeted nanoparticles (NPs). Moreover, we highlight synergistic nanotherapeutics used amplify immune responses combined against Lastly, challenges future expectations field discussed.

Язык: Английский

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Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications

Nano-Micro Letters, Год журнала: 2019, Номер 11(1)

Опубликована: Ноя. 16, 2019

Abstract Cell membrane coating technology is an approach to the biomimetic replication of cell properties, and active area ongoing research readily applicable nanoscale biomedicine. Nanoparticles (NPs) coated with membranes offer opportunity unite natural properties those artificial inner core material. The NPs not only increase their biocompatibility but also achieve effective extended circulation in vivo, allowing for execution targeted functions. Although membrane-coated clear advantages, much work remains before they can be applied clinical practice. In this review, we first provide a comprehensive overview theory technology, followed by summary existing preparation characterization techniques. Next, focus on functions applications various types. addition, collate model drugs used review patent related from past 10 years. Finally, survey future challenges trends pertaining effort development technology.

Язык: Английский

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Nanomedicine in cancer therapy

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Авг. 7, 2023

Cancer remains a highly lethal disease in the world. Currently, either conventional cancer therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that cannot accurately distinguish malignant cells from healthy ones, giving rise to multiple undesired side effects. Recent advances nanotechnology, accompanied by our growing understanding of biology and nano-bio interactions, have led development series nanocarriers, which aim improve efficacy while reducing off-target toxicity encapsulated anticancer agents through tumor tissue-, cell-, organelle-specific targeting. However, vast majority nanocarriers do not possess hierarchical targeting capability, their indices often compromised poor accumulation, inefficient cellular internalization, inaccurate subcellular localization. This Review outlines current prospective strategies design organelle-targeted nanomedicines, highlights latest progress technologies can dynamically integrate these three different stages static maximize outcomes. Finally, we briefly discuss challenges future opportunities for clinical translation nanomedicines.

Язык: Английский

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Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Сен. 30, 2021

Cell membrane coated nanoparticles (NPs) have recently been recognized as attractive nanomedical tools because of their unique properties such immune escape, long blood circulation time, specific molecular recognition and cell targeting. However, the integrity coating on NPs, a key metrics related to quality these biomimetic-systems resulting biomedical function, has remained largely unexplored. Here, we report fluorescence quenching assay probe coating. In contradiction common assumption perfect coating, uncover that up 90% biomimetic NPs are only partially coated. Using in vitro homologous targeting studies, demonstrate could still be internalized by target cells. By combining simulations with experimental analysis, further identify an endocytic entry mechanism for NPs. We unravel high degree (≥50%) enter cells individually, whereas low (<50%) need aggregate together before internalization. This quantitative method fundamental understanding how will enhance rational designing nanosystems pave way more effective cancer nanomedicine.

Язык: Английский

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Multifunctional phototheranostic nanomedicine for cancer imaging and treatment

Materials Today Bio, Год журнала: 2019, Номер 5, С. 100035 - 100035

Опубликована: Ноя. 7, 2019

Cancer, as one of the most life-threatening diseases, shows a high fatality rate around world. When improving therapeutic efficacy conventional cancer treatments, researchers also conduct extensive studies into alternative approaches, which are safe, valid, and economical. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), tumor-ablative function-reserving oncologic interventions, showing strong potential in clinical treatment. During phototherapies, non-toxic phototherapeutic agents can be activated upon light irradiation to induce cell death without causing much damage normal tissues. Besides, with rapid development nanotechnology past decades, phototheranostic nanomedicine has attracted tremendous interests aiming continuously refine their performance. Herein, we reviewed recent progress for improved therapy. After brief introduction principles related PDT PTT, existing works on developing by mainly focusing categories applications, particularly phototherapy-synergized immunotherapy, comprehensively reviewed. More importantly, conclusion future challenges from our point view delivered last part this article.

Язык: Английский

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Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy

ACS Nano, Год журнала: 2019, Номер 14(1), С. 620 - 631

Опубликована: Дек. 26, 2019

Combination therapy that could better balance immune activation and suppressive signals holds great potential in cancer immunotherapy. Herein, we serendipitously found the pH-responsive nanovesicles (pRNVs) self-assembled from block copolymer polyethylene glycol-b-cationic polypeptide can not only serve as a nanocarrier but also cause immunogenic cell death (ICD) through preapoptotic exposure of calreticulin. After coencapsulation photosensitizer, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) an indoleamine 2,3-dioxygenase inhibitor, indoximod (IND), pRNVs/HPPH/IND at single low dose elicited significant antitumor efficacy abscopal effect following laser irradiation B16F10 melanoma tumor model. Treatment attributes to three key factors: (i) singlet oxygen generation by HPPH-mediated photodynamic (PDT); (ii) increased dendritic (DC) recruitment response provocation after ICD induced pRNVs PDT; (iii) microenvironment modulation IND via enhancing P-S6K phosphorylation for CD8+ T development. This study exploited induce host's immunity activation. The "all-in-one" smart allow design multifunctional materials strengthen immunotherapy efficacy.

Язык: Английский

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Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

Nano Letters, Год журнала: 2019, Номер 19(11), С. 8049 - 8058

Опубликована: Сен. 27, 2019

Pyroptosis is a lytic and inflammatory form of programmed cell death could be induced by chemotherapy drugs via caspase-3 mediation. However, the key protein gasdermin E (GSDME, translated DFNA5 gene) during caspase-3-mediated pyroptosis process absent in most tumor cells because hypermethylation (deafness autosomal dominant 5) gene. Here, we develop strategy combining decitabine (DAC) with nanodrugs to trigger epigenetics, further enhancing immunological effect chemotherapy. DAC pre-performed specific tumor-bearing mice for demethylation gene cells. Subsequently, commonly used tumor-targeting nanoliposome loaded cisplatin (LipoDDP) administrate activating pathway pyroptosis. Experiments demonstrate that reversal GSDME silencing achieved facilitates occurrence According anti-tumor activities, anti-metastasis results, inhibition recurrence, this pyroptosis-based enhances effects also provides an important insight into immunotherapy.

Язык: Английский

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