Macromolecular Rapid Communications,
Год журнала:
2021,
Номер
42(10)
Опубликована: Апрель 20, 2021
Abstract
Injectable
hydrogel
possesses
great
application
potential
in
disease
treatment
and
tissue
engineering,
but
damage
to
gel
often
occurs
due
the
squeezing
pressure
from
injection
devices
mechanical
forces
limb
movement,
leads
rapid
degradation
of
matrix
leakage
load
material.
The
self‐healing
injectable
hydrogels
can
overcome
these
drawbacks
via
automatically
repairing
structural
defects
restoring
function.
polysaccharide
constructed
through
Schiff
base
reaction
own
advantages
including
simple
fabrication,
injectability,
under
physiological
conditions,
therefore
have
drawn
extensive
attention
investigation
recently.
In
this
short
review,
preparation
properties
that
is
established
on
are
focused
their
biological
applications
drug
delivery
cell
therapy
discussed.
ACS Nano,
Год журнала:
2021,
Номер
15(8), С. 12567 - 12603
Опубликована: Авг. 2, 2021
Immunotherapy
that
harnesses
the
human
immune
system
to
fight
cancer
has
received
widespread
attention
and
become
a
mainstream
strategy
for
treatment.
Cancer
immunotherapy
not
only
eliminates
primary
tumors
but
also
treats
metastasis
recurrence,
representing
major
advantage
over
traditional
treatments.
Recently
with
development
of
nanotechnology,
there
exists
much
work
applying
nanomaterials
on
basis
their
excellent
physiochemical
properties,
such
as
efficient
tissue-specific
delivery
function,
huge
specific
surface
area,
controllable
chemistry.
Consequently,
nanotechnology
holds
significant
potential
in
improving
efficacy
immunotherapy.
Nanotechnology-based
mainly
manifests
its
inhibitory
effect
via
two
different
approaches:
one
is
produce
an
effective
anti-tumor
response
during
tumorigenesis,
other
enhance
tumor
defense
ability
by
modulating
suppression
mechanism
microenvironment.
With
success
immunotherapy,
understanding
interaction
between
smart
nanomedicine
provided
vigorous
vitality
This
review
highlights
application,
progress,
prospect
process
immunoediting
discusses
several
engineering
methods
improve
efficiency
Immune
responses
stimulated
by
photodynamic
therapy
(PDT)
and
photothermal
(PTT)
are
a
promising
strategy
for
the
treatment
of
advanced
cancer.
However,
antitumor
efficacy
PDT
or
PTT
alone
is
less
potent
unsustainable
against
cancer
metastasis
relapse.
In
this
study,
Gd
Advanced Materials,
Год журнала:
2021,
Номер
33(31)
Опубликована: Май 28, 2021
Abstract
Immunotherapy
that
can
activate
immunity
or
enhance
the
immunogenicity
of
tumors
has
emerged
as
one
most
effective
methods
for
cancer
therapy.
Nevertheless,
single‐mode
immunotherapy
is
still
confronted
with
several
critical
challenges,
such
low
immune
response,
tumor
infiltration,
and
complex
immunosuppression
microenvironment.
Recently,
combination
other
therapeutic
modalities
a
powerful
strategy
to
augment
outcome
in
fighting
against
cancer.
In
this
review,
recent
research
advances
chemotherapy,
phototherapy,
radiotherapy,
sonodynamic
therapy,
metabolic
microwave
thermotherapy
are
summarized.
Critical
challenges
future
direction
immunotherapy‐based
also
discussed.
Macromolecular Rapid Communications,
Год журнала:
2021,
Номер
42(10)
Опубликована: Апрель 20, 2021
Abstract
Injectable
hydrogel
possesses
great
application
potential
in
disease
treatment
and
tissue
engineering,
but
damage
to
gel
often
occurs
due
the
squeezing
pressure
from
injection
devices
mechanical
forces
limb
movement,
leads
rapid
degradation
of
matrix
leakage
load
material.
The
self‐healing
injectable
hydrogels
can
overcome
these
drawbacks
via
automatically
repairing
structural
defects
restoring
function.
polysaccharide
constructed
through
Schiff
base
reaction
own
advantages
including
simple
fabrication,
injectability,
under
physiological
conditions,
therefore
have
drawn
extensive
attention
investigation
recently.
In
this
short
review,
preparation
properties
that
is
established
on
are
focused
their
biological
applications
drug
delivery
cell
therapy
discussed.
