The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment DOI
Pan Zhang, Chao Qin, Nan Liu

и другие.

Biomaterials, Год журнала: 2022, Номер 284, С. 121518 - 121518

Опубликована: Апрель 12, 2022

Язык: Английский

Carbon-based nanozymes: Design, catalytic mechanism, and bioapplication DOI
Yun Sun, Bolong Xu, Xueting Pan

и другие.

Coordination Chemistry Reviews, Год журнала: 2022, Номер 475, С. 214896 - 214896

Опубликована: Окт. 27, 2022

Язык: Английский

Процитировано

152

Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy DOI
Shuang Liang, Jianjun Yao, Dan Liu

и другие.

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Март 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Язык: Английский

Процитировано

136

A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy DOI Creative Commons
Man Wang, Mengyu Chang, Pan Zheng

и другие.

Advanced Science, Год журнала: 2022, Номер 9(31)

Опубликована: Сен. 25, 2022

Abstract Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic tumor microenvironment. Further, to amplify thermal sensitivity of cells, glucose oxidase (GOx) introduced suppress production heat shock proteins, thereby promoting therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate hypoxia, significantly improving GOx activity. As result, combination self‐augmented ability PD‐L1 antibody further escalate antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, PTT, immunotherapy enhancement strategy be favorable tool effectively kill cancer cells.

Язык: Английский

Процитировано

115

Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment DOI Creative Commons
Hailong Tian,

Jiangjun Cao,

Bowen Li

и другие.

Bone Research, Год журнала: 2023, Номер 11(1)

Опубликована: Фев. 27, 2023

Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding efforts of researchers, its five-year rate has only shown limited improvement, suggesting that existing therapeutic strategies are insufficient to meet clinical needs. Notably, immunotherapy certain advantages over traditional tumor treatments inhibiting metastasis. Therefore, managing immune microenvironment osteosarcoma can provide novel and valuable insight into multifaceted mechanisms underlying heterogeneity progression disease. Additionally, given advances nanomedicine, there exist many advanced nanoplatforms for enhanced satisfactory physiochemical characteristics. Here, we review classification, characteristics, functions key components osteosarcoma. This also emphasizes application, progress, prospects discusses several nanomedicine-based options enhance efficiency treatment. Furthermore, examine disadvantages standard present future perspectives immunotherapy.

Язык: Английский

Процитировано

110

Tumor microenvironment-oriented MOFs for chemodynamic therapy DOI Creative Commons

Xiaojiao Di,

Zhichao Pei, Yuxin Pei

и другие.

Coordination Chemistry Reviews, Год журнала: 2023, Номер 484, С. 215098 - 215098

Опубликована: Март 14, 2023

Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic (CDT) based Fenton/Fenton-like reactions a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals (OH) through exploitation of transition metal ions catalysts acidic microenvironment (TME) suitable effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise CDT account their unique properties. Among them, stimuli-responsive nature and porosity MOFs make them ideal TME-targeted cargo delivery. In addition, ability to select appropriate organic ligands makes it possible prepare intrinsic antitumor activity. This review primarily summarizes latest progress application microenvironment-oriented CDT, including or chemodynamic Furthermore, remaining challenges suggestions future applications are also presented.

Язык: Английский

Процитировано

83

Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy DOI Creative Commons
Jiali Luo, Handong Wang, Zhan Shi

и другие.

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Май 14, 2022

Immunotherapeutic interventions represent a promising approach to treating cancer, with strategies such as immune checkpoint blockade (ICB), immunogenic sonodynamic therapy (SDT), and adjuvant T cell delivery having exhibited clinical promise. In this report, we describe the use of cancer membrane-coated triphenylphosphonium (TPP) decorated nano-metal-organic framework (nMOF) constructs [Zr-TCPP(TPP)/R837@M] that were used generate homologous, mitochondria-targeted platforms high rate sonosensitizer loading. This construct was utilized simultaneously promote tumor antigen presentation via enhancing SDT while synergistically promoting dendritic (DC) maturation through Toll-like receptor agonist R837. vitro, these functionalized nMOFs readily internalized by homologous cells in which they efficiently targeted mitochondria, DC activation induction death (ICD) following ultrasound exposure. Moreover, nanoplatform able achieve vivo synergy anti-CTLA-4 ICB reverse immunosuppression microenvironment (TME), thus achieving more robust antitumor efficacy capable suppressing metastatic disease progression facilitating development durable memory responses. Together, results highlight enhanced activity overcoming an immunosuppressive TME, thereby immunity.

Язык: Английский

Процитировано

76

Gold nanoparticles in microelectronics advancements and biomedical applications DOI

Mohamed Mohamady Ghobashy,

Sh. A Alkhursani,

Haifa A. Alqahtani

и другие.

Materials Science and Engineering B, Год журнала: 2024, Номер 301, С. 117191 - 117191

Опубликована: Янв. 13, 2024

Язык: Английский

Процитировано

64

Nanoparticle-mediated cancer cell therapy: basic science to clinical applications DOI Creative Commons
Jaya Verma, Caaisha Warsame, Rajkumar Kottayasamy Seenivasagam

и другие.

Cancer and Metastasis Reviews, Год журнала: 2023, Номер 42(3), С. 601 - 627

Опубликована: Фев. 24, 2023

Every sixth person in the world dies due to cancer, making it second leading severe cause of death after cardiovascular diseases. According WHO, cancer claimed nearly 10 million deaths 2020. The most common types cancers reported have been breast (lung, colon and rectum, prostate cases), skin (non-melanoma) stomach. In addition surgery, widely used traditional anti-cancer treatment are radio- chemotherapy. However, these do not distinguish between normal malignant cells. Additional methods evolved over time for early detection targeted therapy cancer. each method has its limitations associated costs quite high with adverse effects on quality life patients. Use individual atoms or a cluster (nanoparticles) can paradigm shift by virtue providing point sight sensing diagnosis Nanoparticles (1-100 nm size) 1000 times smaller size than human cell endowed safer relocation capability attack mechanically chemically at precise location which is one avenue that be destroy cells precisely. This review summarises extant understanding work done this area pave way physicians accelerate use hybrid mode treatments leveraging various nanoparticles.

Язык: Английский

Процитировано

59

Unleashing the power of porphyrin photosensitizers: Illuminating breakthroughs in photodynamic therapy DOI
Alibasha Akbar, Syamantak Khan, Tanmay Chatterjee

и другие.

Journal of Photochemistry and Photobiology B Biology, Год журнала: 2023, Номер 248, С. 112796 - 112796

Опубликована: Окт. 4, 2023

Язык: Английский

Процитировано

46

Emerging nitric oxide gas‐assisted cancer photothermal treatment DOI Creative Commons
Shuang Liang, Yufei Liu,

Hongquan Zhu

и другие.

Exploration, Год журнала: 2024, Номер 4(6)

Опубликована: Март 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Язык: Английский

Процитировано

42