Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(7)

Опубликована: Янв. 4, 2021

Chemodynamic therapy (CDT) is an emerging method that kills cancer cells by converting intracellular hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals (• OH). To overcome the current limitations of insufficient endogenous H2 and high concentration glutathione (GSH) in tumor cells, intelligent nanocatalytic theranostics (denoted as PGC-DOX) possesses both self-supply GSH-elimination properties for efficient presented. This nanoplatform constructed a facile one-step biomineralization using poly(ethylene glycol)-modified glucose oxidase (GOx) template to form biodegradable copper-doped calcium phosphate nanoparticles, followed loading doxorubicin (DOX). As enzyme catalyst, GOx can effectively catalyze generate , which not only starves but also supplies subsequent Fenton-like reaction. Meanwhile, redox reaction between released Cu2+ ions GSH will induce depletion reduce Fenton agent Cu+ ions, then trigger • OH -mediated reaction, resulting enhanced CDT efficacy. The integration GOx-mediated starvation therapy, CDT, DOX-induced chemotherapy, endow PGC-DOX with effective growth inhibition minimal side effects vivo.

Язык: Английский

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GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

Advanced Materials, Год журнала: 2020, Номер 32(42)

Опубликована: Сен. 11, 2020

Abstract Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity nanozymes in tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria‐like PEG/Ce‐Bi@DMSN nanozyme developed by coating uniform Bi 2 S 3 nanorods (NRs) with dendritic mesoporous silica (Bi @DMSN) then decorating ultrasmall ceria into large mesopores @DMSN. The exhibit dual enzyme‐mimic activities (peroxidase‐mimic catalase‐mimic) under acidic conditions that can regulate TME, is, simultaneously elevate oxidative stress relieve hypoxia. In addition, effectively consume overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) introduced to synergistically improve enzyme‐mimicking depletion GSH tumors photonic hyperthermia. This achieved taking advantage desirable light absorbance second near‐infrared (NIR‐II) window nanozymes. Subsequently reactive oxygen species (ROS)‐mediated efficiency significantly improved. Therefore, this study provides proof concept hyperthermia‐augmented multi‐enzymatic ablation.

Язык: Английский

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Год журнала: 2021, Номер 18(6)

Опубликована: Ноя. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Язык: Английский

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Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Год журнала: 2021, Номер 33(48)

Опубликована: Сен. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Язык: Английский

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Recent Advances in Nanozymes: From Matters to Bioapplications

Advanced Functional Materials, Год журнала: 2021, Номер 32(14)

Опубликована: Дек. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Язык: Английский

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Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy

Advanced Materials, Год журнала: 2020, Номер 32(33)

Опубликована: Июль 6, 2020

Abstract Nanozyme‐based tumor catalytic therapy has attracted widespread attention in recent years. However, its therapeutic outcomes are diminished by many factors the microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H 2 O ) concentration, hypoxia, and immunosuppressive microenvironment. Herein, an immunomodulation‐enhanced nanozyme‐based strategy is first proposed to achieve synergism between nanozymes TME regulation. TGF‐β inhibitor (TI)‐loaded PEGylated iron manganese silicate nanoparticles (IMSN) (named IMSN‐PEG‐TI) constructed trigger modality. The results show that IMSN nanozyme exhibits both intrinsic peroxidase‐like catalase‐like activities under acidic TME, which can decompose H into hydroxyl radicals (•OH) oxygen (O ), respectively. Besides, it demonstrated TI regulate immune microenvironment, resulting macrophage polarization from M2 M1, thus inducing regeneration of , promote nanozyme. potent antitumor effect IMSN‐PEG‐TI proved vitro multicellular spheroids (MCTS) vivo CT26‐tumor‐bearing mice models. It believed treatment a promising tool kill cancer cells.

Язык: Английский

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Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

ACS Nano, Год журнала: 2021, Номер 15(5), С. 8039 - 8068

Опубликована: Май 11, 2021

Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has been observed in many cancer cells, solid evidence corroborated resulting tumor a variety anticancer therapies, suggesting that this biochemical characteristic can be developed as potential target for treatments. The single treatment GSH-depleting agents potentiate responses different cell death stimuli; therefore, an adjunctive strategy, GSH depletion is usually combined with mainstream therapies enhancing Propelled by rapid development nanotechnology, readily constructed into nanomedicines, have shown steep rise over past decade. Here, we review common nanomedicines widely applied synergistic treatments recent years. Some current challenges future perspectives depletion-based are also presented. With understanding structure–property relationship action mechanisms these biomaterials, hope nanotechnology will further realize more effective disease even achieve successful clinical translations.

Язык: Английский

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Nanozymes-recent development and biomedical applications

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Фев. 22, 2022

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.

Язык: Английский

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Multifunctional Injectable Hydrogel Dressings for Effectively Accelerating Wound Healing: Enhancing Biomineralization Strategy

Advanced Functional Materials, Год журнала: 2021, Номер 31(23)

Опубликована: Март 31, 2021

Abstract Bacterial infection can cause chronic nonhealing wounds, which may be a great threat to public health. It is highly desirable develop an injectable wound dressing hydrogel with multifunctions including self‐healing, remodeling, antibacterial, radical scavenging ability, and excellent photothermal properties promote the regeneration of damaged tissues in clinical practice. In this work, dopamine‐modified gelatin (Gel‐DA) employed for first time as biotemplate enhancing biomineralization ability synthesize gelatin@Ag nanoparticles (Gel‐DA@Ag NPs). Further, prepared Gel‐DA@Ag NPs antioxidant activity near‐infrared (NIR) laser irradiation synergistic antibacterial behavior are fixed guar gum based hydrogels through formation borate/didiol bonds possess remolding, injectable, self‐healing performance. addition, multifunctional completely cover irregular shape prevent secondary injury. More importantly, these platforms under NIR significantly accelerate healing more skin appendages like hair follicles blood vessels appearing. Therefore, it expected that serve competitive dressings biomedical field, bacteria‐derived other tissue repair related reactive oxygen species overexpression.

Язык: Английский

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A Bioinspired Five‐Coordinated Single‐Atom Iron Nanozyme for Tumor Catalytic Therapy

Advanced Materials, Год журнала: 2022, Номер 34(15)

Опубликована: Фев. 1, 2022

Single-atom nanozymes (SAzymes) represent a new research frontier in the biomedical fields. The rational design and controllable synthesis of SAzymes with well-defined electronic geometric structures are essential for maximizing their enzyme-like catalytic activity therapeutic efficacy but remain challenging. Here, melamine-mediated pyrolysis activation strategy is reported fabrication iron-based SAzyme containing five-coordinated structure (FeN5 ), identified by transmission electron microscopy imaging X-ray absorption fine analyses. FeN5 exhibits superior peroxidase-like owing to optimized coordination structure, corresponding efficiency Fe-species 7.64 3.45 × 105 times higher than those traditional FeN4 Fe3 O4 nanozyme, respectively, demonstrated steady-state kinetic assay. In addition, mechanism jointly disclosed experimental results density functional theory studies. as-synthesized demonstrates significantly enhanced antitumor effect vitro vivo due excellent under tumor microenvironment.

Язык: Английский

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