Photoacoustic
(PA)
imaging
and
photothermal
therapy
(PTT)
have
attracted
extensive
attention
in
disease
diagnosis
treatment.
Although
many
exogenous
contrast
agents
been
developed
for
PA
PTT,
the
design
guidelines
to
amplify
their
performances
remain
challenging
are
highly
demanded.
Semiconducting
polymer
nanoparticles
(SPNs)
composed
of
polymers
with
π-electron
delocalized
backbones
can
be
designed
PTT
performance,
because
clear
structure-property
relation
versatility
modifying
molecular
structures
tune
photophysical
properties.
This
review
summarizes
recent
advances
photoacoustic
applications
semiconducting
a
focus
on
signal
amplification
second
near-infrared
(NIR-II,
1000-1700
nm)
construction.
The
strategies
such
as
screening,
fluorescence
quenching,
accelerated
heat
dissipation,
size-dependent
dissipation
first
discussed
brightness
SPNs
vivo
PA.
approaches
shifting
absorption
NIR-II
then
introduced
so
improve
tissue
penetration
depth
therapy.
At
last,
current
challenges
perspectives
field
discussed.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(46), С. 20582 - 20588
Опубликована: Июль 20, 2020
Inspired
by
the
dynamic
morphology
control
of
molecular
assemblies
in
biological
systems,
we
have
developed
pH-responsive
transformable
peptide-based
nanoparticles
for
photodynamic
therapy
(PDT)
with
prolonged
tumor
retention
times.
The
self-assembled
peptide-porphyrin
transformed
into
nanofibers
when
exposed
to
acidic
microenvironment,
which
was
mainly
driven
enhanced
intermolecular
hydrogen
bond
formation
between
protonated
molecules.
nanoparticle
transformation
fibrils
improved
their
singlet
oxygen
generation
ability
and
enabled
high
accumulation
long-term
at
sites.
Strong
fluorescent
signals
these
nanomaterials
were
detected
tissue
up
7
days
after
administration.
Moreover,
peptide
exhibited
excellent
anti-tumor
efficacy
via
PDT
vivo.
This
situ
fibrillar
strategy
could
be
utilized
design
effective
stimuli-responsive
biomaterials
imaging
therapy.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(43)
Опубликована: Авг. 7, 2020
Abstract
Cancer
immunotherapy
has
received
tremendous
attention
in
the
past
decade
owing
to
its
clinical
successes
with
use
of
immune‐checkpoint
inhibition
and
chimeric
antigen
receptor
T
cell
therapy.
However,
only
a
small
proportion
patients
have
benefited
from
these
immunotherapeutic
drugs,
which
raised
concerns
about
low
response
rate
immune‐related
adverse
events.
Nanomedicines
served
as
paradigm
for
preferential
tumor
accumulation
but
still
confront
issues
such
poor
circulation
insufficient
accumulation.
By
virtue
coating
nanoparticles
membranes
diverse
sources,
active
proteins
on
can
impart
variety
desired
functionalities
or
supplementary
therapeutic
effects
nanoparticles,
providing
ways
enhanced
cancer
immunotherapy.
In
this
review,
recent
advances
membrane
camouflaged
applied
improved
are
discussed
basis
different
sources
corresponding
working
mechanisms.
These
biomimetic
potentially
deliver
agents
designated
sites
actively
engage
particular
stages
immunity
cycle,
eliciting
antitumor
less
off‐target
toxicities.
Chemical Society Reviews,
Год журнала:
2020,
Номер
49(24), С. 9057 - 9094
Опубликована: Янв. 1, 2020
This
review
provides
a
comprehensive
overview
of
the
recent
advances
in
nanoplatform-based
cascade
engineering
for
cancer
therapy,
by
concentrating
on
design
smart
nanoplatforms
and
implementation
specific
processes.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Июнь 13, 2022
Abstract
Although
two-dimensional
(2D)
layered
double
hydroxides
(LDHs)
have
been
widely
used
as
efficient
nanoagents
for
biological
diagnosis
and
treatment,
they
found
to
be
inert
photosensitizers
(PSs)
photodynamic
therapy
(PDT).
Herein,
we
report
the
defect
engineering
of
ultrathin
2D
CoMo-LDH
NiMo-LDH
nanosheets
highly
active
inorganic
PSs
PDT
in
third
near-infrared
(NIR-III)
window.
Hydrothermal-synthesized
are
etched
via
a
simple
acid
treatment
obtain
defect-rich
nanosheets.
Importantly,
exhibit
much
higher
activity
(~97
times)
generation
reactive
oxygen
species
than
that
pristine
under
NIR-III
1567
nm
laser
irradiation.
Therefore,
after
modification
with
polyethylene
glycol,
can
an
PS
efficiently
induce
cancer
cells
apoptosis
vitro
eradicate
tumors
vivo
Advanced Materials,
Год журнала:
2021,
Номер
34(8)
Опубликована: Дек. 2, 2021
Cancer
nanomedicine
combined
with
immunotherapy
has
become
a
promising
strategy
for
treating
cancer
in
terms
of
safety
and
potency;
however,
precise
regulation
the
activation
antitumor
immunity
remains
challenging.
Herein,
smart
semiconducting
polymer
nano-immunomodulator
(SPNI),
which
responds
to
acidic
tumor
microenvironment
(TME),
precision
photodynamic
cancer,
is
reported.
The
SPNI
self-assembled
by
near-infrared
(NIR)-absorbing
an
amphipathic
conjugated
Toll-like
receptor
7
(TLR7)
agonist
via
acid-labile
linker.
Upon
arrival
at
site,
undergoes
hydrolysis
triggers
efficient
liberation
TLR7
response
TME
dendritic
cell
activation.
Moreover,
exerts
effects
direct
eradication
immunogenic
death
under
NIR
photoirradiation.
synergistic
action
released
factors
acidic-TME-activated
can
serve
as
situ
generated
vaccine
evoke
strong
activities.
Notably,
such
localized
immune
boosts
systemic
responses,
resulting
enhanced
cytotoxic
CD8+
T
infiltration
inhibit
growth
metastasis.
Thereby,
this
work
presents
general
devise
prodrug
immunotherapeutics
immunotherapy.
Biomaterials,
Год журнала:
2022,
Номер
290, С. 121856 - 121856
Опубликована: Окт. 18, 2022
cGAS-STING
pathway,
as
an
essential
intracellular
immune
response
has
attracted
much
attention
in
tumor
immunotherapy.
However,
low
metabolic
stability
of
conventional
STING
agonists
limits
their
clinical
application.
Recent
study
shows
that
chemotherapeutic
drugs
cisplatin
and
camptothecin
(CPT)
can
activate
pathway
induce
by
DNA
damage.
Nevertheless,
the
ability
to
is
so
weak
new
strategies
are
required
improve
drug
delivery
efficiency
for
enhanced
damage,
then
efficiently
pathway.
Herein,
we
have
developed
a
hybrid
platinum
prodrug
(CPT-Pt
(IV))
which
be
triggered
release
CPT
cells.
CPT-Pt
(IV)
with
high
hydrophobicity
further
self-assembled
ROS
sensitive
polymer
(P1)
mPEG2k-DSPE
into
responsive
nanoparticles
(NPs).
NPs
could
accumulate
site
CPT,
resulting
double
damage
finally
activating
inducing
DC
cells
maturation
increasing
infiltration
CD8+
T
on
colorectal
cancer
mouse
model.
This
showed
common
targeted
situ
via
nano
system,
enhance
effect
chemotherapy
immunotherapy,
provide
strategy
antitumor
therapy.
