Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Advanced Functional Materials, Год журнала: 2021, Номер 31(22)

Опубликована: Март 8, 2021

Abstract Triggered by the endogenous chemical energy in tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention recent years. The agents can convert internal hydrogen peroxide (H 2 O ) into lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other modalities, CDT possesses many notable advantages, such tumor‐specific, highly selective, fewer systemic side effects, and no need external stimulation. Nevertheless, mild acid pH, low H content, overexpressed reducing substance TME severely suppressed efficiency. With rapid development of nanotechnology, some kinds nanomaterials have been utilized improved In particular, excellent photo‐, ultrasound‐, magnetic‐, stimuli‐response properties make it possible combination cancer shown superior anti‐cancer activity than monotherapies. Therefore, is necessary to summarize application nanomaterial‐based therapy. this review, various nanomaterials‐based nanoplatforms its combinational therapies are summarized discussed, aiming provide inspiration design better‐quality promote lay foundation future conversion clinical applications.

Язык: Английский

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Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry

Chemical Science, Год журнала: 2021, Номер 13(4), С. 863 - 889

Опубликована: Ноя. 29, 2021

Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is most significant feature of chemodynamic (CDT). Owing to mild acid and overexpressed H2O2 TME, more cytotoxic hydroxyl radicals (˙OH) are generated cells via Fenton-like reactions. Without external stimulus drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific desirable anticancer effect has been seen as promising strategy therapy. However, optimizing treatment efficiency TME still challenging because limited catalytic agents strong antioxidant capacity TME. Hence, scientists trying their best design fabricate many with excellent activity remodeling optimal CDT. In this perspective, latest progress discussed, some representative examples presented. Consequently, strategies further guided by provided. Most importantly, several feasible ways developing future offered reference.

Язык: Английский

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Fe₃O₄/Ag/Bi₂MoO₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(52)

Опубликована: Окт. 9, 2021

Abstract Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of current are limited and their efficiency is usually compromised not sustainable in tumor microenvironment (TME). Therefore, combination involving additional therapeutics often necessary resulting complication may jeopardize practical feasibility. Herein, an unprecedented “all‐in‐one” Fe 3 O 4 /Ag/Bi 2 MoO 6 nanoparticle (FAB NP) rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal with guidance by magnetic resonance, photoacoustic, imaging. Based its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) photodynamic property, cascaded nanocatalytic reactions enabled sustained TME for outstanding therapeutic outcomes. The working mechanisms underlying intraparticulate interactions, sustainability, self‐replenishment arising from coupling between carefully revealed, providing new insights into design novel high efficiency, good specificity, low side effects.

Язык: Английский

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A Cascade Nanozyme with Amplified Sonodynamic Therapeutic Effects through Comodulation of Hypoxia and Immunosuppression against Cancer

ACS Nano, Год журнала: 2021, Номер 16(1), С. 485 - 501

Опубликована: Дек. 28, 2021

The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal to cancer deterioration metastasis. Thus, regulating the TME improve cell ablation efficiency has received extensive interest in oncotherapy. However, reverse alleviate simultaneously are major challenges for effective therapy. Herein, a multifunctional platform based on Au nanoparticles carbon dots modified hollow black TiO2 nanosphere (HABT-C) with intrinsic cascade enzyme mimetic activities prepared reversing alleviating TME. HABT-C NPs possess triple-enzyme activity act as self-cascade nanozymes, which produce sufficient oxygen generate abundant ROS. theoretical analysis demonstrates that facilitates absorption of H2O O2, separation electron–holes, generation ROS, consequently amplifying sonodynamic therapy (SDT) efficiency. Specifically, exhibits favorable inhibition immunosuppressive mediator expression, along infiltrating immune effector cells into As result, can effectively kill via eliciting infiltration, hypoxia, improving SDT This nanozyme-based (HABT-C@HA) will provide strategy highly efficient against modulation

Язык: Английский

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Metal organic frameworks for antibacterial applications

Chemical Engineering Journal, Год журнала: 2022, Номер 435, С. 134975 - 134975

Опубликована: Фев. 2, 2022

Язык: Английский

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Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Advanced Functional Materials, Год журнала: 2021, Номер 31(50)

Опубликована: Сен. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Язык: Английский

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The Intracellular and Extracellular Microenvironment of Tumor Site: The Trigger of Stimuli‐Responsive Drug Delivery Systems

Small Methods, Год журнала: 2022, Номер 6(3)

Опубликована: Янв. 20, 2022

Abstract The tumor microenvironment (TME), including intracellular and extracellular microenvironment, contains many biochemical indicators (such as acidity/alkalinity, oxygen content, enzymatic activity) that are different from the normal physiological environment. These abnormal can accelerate heterogeneity of tumors, but on other hand, they also provide opportunities for design intelligent drug delivery systems (DDSs). TME‐responsive DDSs have shown great potential in reducing side effects chemotherapy improving curative effect tumors. In this review, TME introduced detail both aspects. view various barriers encountered during delivery, strategy constructing is discussed. By summarizing typical research progress, authors prospect development DDS future.

Язык: Английский

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Noncancerous disease-targeting AIEgens

Chemical Society Reviews, Год журнала: 2023, Номер 52(3), С. 1024 - 1067

Опубликована: Янв. 1, 2023

Schematic diagram of noncancerous disease-targeting AIEgens.

Язык: Английский

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Pt nanozyme-bridged covalent organic framework-aptamer nanoplatform for tumor targeted self-strengthening photocatalytic therapy

Biomaterials, Год журнала: 2023, Номер 297, С. 122109 - 122109

Опубликована: Апрель 4, 2023

Язык: Английский

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Engineering lactate-modulating nanomedicines for cancer therapy

Chemical Society Reviews, Год журнала: 2023, Номер 52(3), С. 973 - 1000

Опубликована: Янв. 1, 2023

Lactate in tumors has long been considered "metabolic junk" derived from the glycolysis of cancer cells and utilized only as a biomarker malignancy, but is presently believed to be pivotal regulator tumor development, maintenance metastasis. Indeed, lactate can "fuel" for energy supply functions signaling molecule, which actively contributes progression, angiogenesis, immunosuppression, therapeutic resistance, etc., thus providing promising opportunities treatment. However, current approaches regulating homeostasis with available agents are still challenging, mainly due short half-life, low bioavailability poor specificity these their unsatisfactory outcomes. In recent years, modulation nanomedicines have emerged charming efficient strategy fighting cancer, play important roles optimizing delivery lactate-modulating more precise effective Integrating specific diverse may overcome intrinsic restrictions different modalities by remodeling pathological microenvironment achieving enhanced therapy. this review, most advances engineering functional that modulate therapy summarized discussed, fundamental mechanisms benefits various therapeutics elucidated. Finally, challenges perspectives emerging anti-tumor field highlighted.

Язык: Английский

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