Proceedings of the National Academy of Sciences,
Год журнала:
2023,
Номер
120(18)
Опубликована: Апрель 25, 2023
A
fundamental
understanding
of
cell
shaping
with
confined
flexible
filaments,
including
microtubules,
actin
and
engineered
nanotubes,
has
been
limited
by
the
complex
interplay
between
membrane
encapsulated
filaments.
Here,
combining
theoretical
modeling
molecular
dynamics
simulations,
we
investigate
packing
an
open
or
closed
filament
inside
a
vesicle.
Depending
on
relative
stiffness
size
to
vesicle
as
well
osmotic
pressure,
could
evolve
from
axisymmetric
configuration
general
maximum
three
reflection
planes,
bend
in
out
plane
even
coil
up.
plethora
system
morphologies
are
determined.
Morphological
phase
diagrams
predicting
conditions
shape
symmetry
transitions
established.
Organization
filaments
bundles,
nanotube
rings
vesicles,
liposomes,
cells
discussed.
Our
results
provide
basis
understand
cellular
stability
help
guide
development
design
artificial
biohybrid
microrobots.
Chemical Society Reviews,
Год журнала:
2022,
Номер
52(2), С. 728 - 778
Опубликована: Дек. 20, 2022
Block
copolymer
vesicles
are
well
suited
as
nano-sized
drug
delivery
vehicles
for
therapeutic
proteins.
However,
they
have
not
reached
the
clinic
yet.
Why?
The
review
discusses
opportunities
and
obstacles
of
polymersome-based
protein
delivery.
Advanced Functional Materials,
Год журнала:
2021,
Номер
32(2)
Опубликована: Окт. 4, 2021
Abstract
Appropriate
deciphering
and
translation
of
sequence‐dependent
function
in
proteins
is
inspired
by
the
cation–π
interaction
that
increasingly
implicated
marine
adhesives
membraneless
organelles.
A
simplified
cation‐methylene‐phenyl
(C‐M‐P)
sequence
which
enables
triggerable
poly(ionic
liquid)
coacervation
reported
for
first
time.
Synthesis
C‐M‐P
structure
motif
requires
only
a
one‐step
quaternization,
facile
compared
to
linear
distinct
repeating
units
model
sequence‐controlled
polymers.
The
code
confers
modular
advanced
wet
adhesion
task‐specific
copolymers.
It
allows
exceptional
underwater
various
submerged
substrates
including
glass
(≈1
MPa)
porcine
skins
(140
KPa),
paving
way
prospective
adhesive
applications
physiological
saline
salvage.
This
work
introduces
powerful
that,
addition
combining
advantageous
adaptive
phase
properties
proteins,
reduces
complexity
design
programmable
coacervates.
Advanced Energy Materials,
Год журнала:
2021,
Номер
12(3)
Опубликована: Дек. 10, 2021
Abstract
Electrochemical
CO
2
conversion
offers
an
attractive
route
for
recycling
with
economic
and
environmental
benefits,
while
the
catalytic
materials
electrode
structures
still
require
further
improvements
scale‐up
application.
Electrocatalytic
surface
near‐surface
engineering
(ESE)
has
great
potential
to
advance
reduction
reactions
(CO
RR)
improved
activity,
selectivity,
energetic
efficiency,
stability,
reduced
overpotentials.
This
review
initially
provides
a
panorama
of
ESE
effects
give
clear
perspective
leverage
their
advantages,
including
electronic
effects,
ensemble
strain
local
environment
effects.
Additionally,
relevant
in
situ
spectroscopic
characterization
techniques
detect,
theoretical
computational
approaches
reveal
these
are
presented.
Typical
strategies
also
summarized,
e.g.,
reconstruction,
morphology
control,
modifications,
etc.
Rational
manipulations
specific
or
combinations
them
critical
designing
composite
catalysts
electrodes,
consequently
promoting
sustainable
development
steadily
increasing
prosperity
this
field.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Фев. 6, 2024
Abstract
Hierarchical
compartmentalization,
a
hallmark
of
both
primitive
and
modern
cells,
enables
the
concentration
isolation
biomolecules,
facilitates
spatial
organization
biochemical
reactions.
Coacervate-based
compartments
can
sequester
recruit
large
variety
molecules,
making
it
an
attractive
protocell
model.
In
this
work,
we
report
spontaneous
formation
core-shell
cell-sized
coacervate-based
driven
by
evaporation
sessile
droplet
on
thin-oil-coated
substrate.
Our
analysis
reveals
that
such
far-from-equilibrium
architectures
arise
from
multiple,
coupled
segregative
associative
liquid-liquid
phase
separation,
are
stabilized
stagnation
points
within
evaporating
droplet.
The
results
convective
capillary
flows
induced
maximum
rate
at
liquid-liquid-air
contact
line.
This
work
provides
valuable
insights
into
maintenance
hierarchical
under
non-equilibrium
conditions,
offering
glimpse
real-life
scenario.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(34)
Опубликована: Июнь 7, 2024
The
membranization
of
membrane-less
coacervates
paves
the
way
for
exploitation
complex
protocells
with
regard
to
structural
and
cell-like
functional
behaviors.
However,
controlled
transformation
from
membranized
vesicles
remains
a
challenge.
This
can
provide
stable
(multi)phase
(multi)compartmental
architectures
through
reconfiguration
coacervate
droplets
in
presence
(bioactive)
polymers,
bio(macro)molecules
and/or
nanoobjects.
Herein,
we
present
continuous
protocell
and,
ultimately,
giant
hybrid
vesicles.
process
is
orchestrated
by
altering
balance
non-covalent
interactions
varying
concentrations
an
anionic
terpolymer,
leading
dynamic
processes
such
as
spontaneous
terpolymer
nanoparticles
at
surface,
disassembly
phase
mediated
excess
charge,
redistribution
components
membrane.
diverse
during
course
distinct
features
molecular
permeability.
Notably,
introduction
multiphase
this
signifies
advancements
toward
creation
synthetic
cells
different
diffusible
compartments.
Our
findings
emphasize
highly
reorganization
represents
novel
step
development
advanced
sophisticated
more
precise
compositions
(membrane)
structures.
IEEE Open Journal of Circuits and Systems,
Год журнала:
2021,
Номер
2, С. 702 - 720
Опубликована: Янв. 1, 2021
Recent
advances
in
flexible
electronics
have
offered
a
good
opportunity
designing
variety
of
wearable
devices
for
healthcare
monitoring,
prevention
medicine,
and
robotic
control.
Wearable
sensors
are
entering
the
era
digital
health,
with
compelling
functionalities
recording
vital
signs,
physiological
signals,
body
kinetics,
dynamic
biomolecular
state.
Meanwhile,
energy
harvesters
that
scavenge
waste
from
motions
ambient
environment
received
intense
attention,
which
expected
to
realize
self-powered
or
energy-autonomous
systems.
Moving
towards
inside
body,
implantable
device
also
plays
an
indispensable
role
monitoring
key
biomedical
information
effective
treatment
chronic
diseases.
Besides,
exoskeletons
enabled
advanced
assisting
augmenting
human
mobilities
unprecedently.
These
technologies
platforms
will
be
merged,
giving
way
bodyNET:
network
sensors,
devices,
improved
health
outcomes.
In
this
article,
we
offer
brief
review
recent
summarize
progress
based
on
piezoelectric
triboelectric
nanogenerators.
We
discuss
neuromodulation
systems
works
lower-limb
exoskeletons.
Lastly,
present
future
trend
comprehensive
capable
bodyNET
reinforced
life
quality.
Chemical Reviews,
Год журнала:
2021,
Номер
121(22), С. 13996 - 14030
Опубликована: Ноя. 9, 2021
Hierarchic
self-assembly
underpins
much
of
the
form
and
function
seen
in
synthetic
or
biological
soft
materials.
Lipids
are
paramount
examples,
building
themselves
nature
synthetically
a
variety
meso/nanostructures.
Synthetic
block
copolymers
capture
many
lipid's
structural
functional
properties.
typically
biocompatible
high
molecular
weight
polymers
mechanically
robust
chemically
versatile.
The
development
new
materials
for
applications
like
controlled
drug/gene/protein
delivery,
biosensors,
artificial
cells
often
requires
combination
lipids
polymers.
emergent
composite
material,
"polymer–lipid
hybrid
membrane",
displays
synergistic
properties
not
pure
components.
Specific
examples
include
observation
that
membranes
undergo
lateral
phase
separation
can
correlate
registry
across
multiple
layers
into
three-dimensional
phase-separated
system
with
enhanced
permeability
encapsulated
drugs.
It
is
timely
to
underpin
these
several
categories
systems
ranging
from
colloidal
suspensions
supported
films.
In
this
review,
we
discuss
vast
number
polymer–lipid
published
date.
We
rationalize
results
raise
fundamental
understanding
self-assembling
as
well
enable
design
supramolecular
applications.
