Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Год журнала: 2021, Номер 121(21), С. 13454 - 13619

Опубликована: Сен. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Язык: Английский

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Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

Aggregate, Год журнала: 2020, Номер 1(1), С. 80 - 106

Опубликована: Дек. 1, 2020

Abstract Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized precision medicine. By virtue good biocompatibility, outstanding fluorescence property, easy processability functionalization, promoted photosensitizing efficiency, well facile construction multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible vigorous vitality field theranostics. Numerous significant breakthroughs state‐of‐the‐art progression have been witnessed past few years. This review highlights aggregation‐enhanced superiorities AIE luminogens (AIEgens) disease theranostics mainly involving diagnostic imaging (fluorescence room temperature phosphorescence), therapeutic intervention (photodynamic therapy), feasibility based on experimental measurements theoretical simulations. Additionally, latest advanced developments AIEgens aspect corresponding strategies design highly effective AIE‐active through triggering aggregation formation are comprehensively summarized. Moreover, brief conclusion discussion current challenges future perspectives this area is further presented.

Язык: Английский

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The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Год журнала: 2022, Номер 51(6), С. 1983 - 2030

Опубликована: Янв. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Язык: Английский

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Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(18)

Опубликована: Апрель 1, 2021

Abstract The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) with greatly improved sonosensitizing effect simply constructed used enhanced SDT. Compared the commonly TiO 2 , D‐MOF(Ti) results in superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves US‐triggered electron–hole separation. Meanwhile, existence Ti 3+ ions, also exhibits high level Fenton‐like activity enable chemodynamic therapy. Particularly, US as excitation source SDT can simultaneously enhance reaction achieve remarkably synergistic outcomes oncotherapy. More importantly, be degraded metabolized out body after completion therapeutic functions without off‐target toxicity. Overall, this work identifies novel Ti‐familial harboring great potential cancer

Язык: Английский

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Gathering brings strength: How organic aggregates boost disease phototheranostics

Aggregate, Год журнала: 2021, Номер 2(1), С. 95 - 113

Опубликована: Янв. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Язык: Английский

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Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405

Опубликована: Июль 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Язык: Английский

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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Год журнала: 2022, Номер 122(6), С. 6850 - 6918

Опубликована: Март 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Язык: Английский

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Improving Image‐Guided Surgical and Immunological Tumor Treatment Efficacy by Photothermal and Photodynamic Therapies Based on a Multifunctional NIR AIEgen

Advanced Materials, Год журнала: 2021, Номер 33(22)

Опубликована: Апрель 26, 2021

Multimodal therapy is attracting increasing attention to improve tumor treatment efficacy, but generally requires various complicated ingredients combined within one theranostic system achieve multiple functions. Herein, a multifunctional nanoplatform based on single aggregation-induced-emission luminogen (AIEgen), DDTB, designed integrate near-infrared (NIR) fluorescence, photothermal, photodynamic, and immunological effects. Intravenously injected AIEgen-based nanoparticles can efficiently accumulate in tumors with NIR fluorescence provide preoperative diagnosis. Most of the are excised under intraoperative navigation, whereafter, some microscopic residual completely ablated by photodynamic photothermal therapies for maximally killing cells tissues. Up 90% survival rate be achieved this synergistic image-guided surgery therapies. Importantly, nanoparticles-mediated photothermal/photodynamic plus programmed death-ligand 1 antibody significantly induce elimination enhancing effect immunotherapy. This strategy basis AIEgen improves cancer mice maximized therapeutic outcomes, holds great promise clinical treatment.

Язык: Английский

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Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

Chemical Society Reviews, Год журнала: 2023, Номер 52(16), С. 5607 - 5651

Опубликована: Янв. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Язык: Английский

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Good Steel Used in the Blade: Well‐Tailored Type‐I Photosensitizers with Aggregation‐Induced Emission Characteristics for Precise Nuclear Targeting Photodynamic Therapy

Advanced Science, Год журнала: 2021, Номер 8(14)

Опубликована: Май 21, 2021

Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration distinctive strategy involving both high-performance less-oxygen-dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, precise nuclear targeting protocol based on type-I PSs with aggregation-induced emission (AIE) characteristics fabricated first time. Of two synthesized AIE PSs, TTFMN demonstrated exhibit superior property stronger reactive species (ROS) generation efficiency owing introduction tetraphenylethylene smaller singlet-triplet energy gap, respectively. With aid lysosomal acid-activated TAT-peptide-modified amphiphilic polymer poly(lactic acid)12k-poly(ethylene glycol)5k-succinic anhydride-modified TAT, corresponding TTFMN-loaded nanoparticles accompanied acid-triggered peculiarity can quickly accumulate tumor site, effectively generate ROS region suppress growth under white light irradiation minimized systematic toxicity. This delicate "Good Steel Used Blade" tactic maximizes efficacy offers conceptual while practical paradigm optimized treatment further translational medicine.

Язык: Английский

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