ACS Nano,
Год журнала:
2021,
Номер
15(4), С. 7328 - 7339
Опубликована: Апрель 2, 2021
Precise
molecular
engineering
is
the
most
fundamental
and
even
a
great
challenging
task
for
development
of
small
organic
fluorophores
used
as
phototheranostic
agents
in
multimodal
imaging-guided
synergistic
therapy.
To
best
our
knowledge,
there
have
been
no
previous
reports
regarding
fine
fabrication
structure
from
proof-of-concept
study,
providing
single
molecule
with
all
modalities.
Herein,
an
electron
donating–accepting
(D–A)
system
constructed
by
using
triphenylamine
derivatives
donors
diverse
electron-deficient
partners
acceptors,
yielding
aggregation-induced
emission
luminogens
tunable
wavelength
(up
to
933
nm)
light
absorption
capability
(ε
up
6.9
×
104
M–1
cm–1).
Notably,
integrating
spin–orbit
coupling-promoted
carbonyl
group
strong
stretching
vibrations
−CN
D–A
systems,
highly
performing
agent,
namely,
MeTIC,
constructed.
When
encapsulating
MeTIC
into
nanovehicles,
obtained
nanoparticles
show
excellent
performance
multimodality
theranostics
cancer
treatment.
This
work
expected
provide
agent
designing
principle
potential
clinical
trials.
Chemical Reviews,
Год журнала:
2021,
Номер
121(21), С. 13454 - 13619
Опубликована: Сен. 28, 2021
This
review
presents
a
robust
strategy
to
design
photosensitizers
(PSs)
for
various
species.
Photodynamic
therapy
(PDT)
is
photochemical-based
treatment
approach
that
involves
the
use
of
light
combined
with
light-activated
chemical,
referred
as
PS.
Attractively,
PDT
one
alternatives
conventional
cancer
due
its
noninvasive
nature,
high
cure
rates,
and
low
side
effects.
PSs
play
an
important
factor
in
photoinduced
reactive
oxygen
species
(ROS)
generation.
Although
concept
photosensitizer-based
photodynamic
has
been
widely
adopted
clinical
trials
bioimaging,
until
now,
our
surprise,
there
no
relevant
article
on
rational
designs
organic
PDT.
Furthermore,
most
published
articles
focused
nanomaterials
nanotechnology
based
traditional
PSs.
Therefore,
this
aimed
at
reporting
recent
strategies
develop
innovative
enhanced
therapy,
each
example
described
detail
instead
providing
only
general
overview,
typically
done
previous
reviews
PDT,
provide
intuitive,
vivid,
specific
insights
readers.
Aggregate,
Год журнала:
2020,
Номер
1(1), С. 80 - 106
Опубликована: Дек. 1, 2020
Abstract
Theranostics
referring
to
the
ingenious
integration
of
diagnostics
and
therapeutics
has
garnered
tremendous
attention
in
these
years
as
it
provides
a
promising
opportunity
for
modern
personalized
precision
medicine.
By
virtue
good
biocompatibility,
outstanding
fluorescence
property,
easy
processability
functionalization,
promoted
photosensitizing
efficiency,
well
facile
construction
multi‐modality
theranostics,
fluorophores
with
aggregation‐induced
emission
(AIE)
characteristics
exhibit
inexhaustible
vigorous
vitality
field
theranostics.
Numerous
significant
breakthroughs
state‐of‐the‐art
progression
have
been
witnessed
past
few
years.
This
review
highlights
aggregation‐enhanced
superiorities
AIE
luminogens
(AIEgens)
disease
theranostics
mainly
involving
diagnostic
imaging
(fluorescence
room
temperature
phosphorescence),
therapeutic
intervention
(photodynamic
therapy),
feasibility
based
on
experimental
measurements
theoretical
simulations.
Additionally,
latest
advanced
developments
AIEgens
aspect
corresponding
strategies
design
highly
effective
AIE‐active
through
triggering
aggregation
formation
are
comprehensively
summarized.
Moreover,
brief
conclusion
discussion
current
challenges
future
perspectives
this
area
is
further
presented.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(6), С. 1983 - 2030
Опубликована: Янв. 1, 2022
This
review
summarized
the
progression
of
AIEgen-based
photo-driven
theranostics
emphasizing
on
design
strategies
for
efficient
photosensitization,
photothermal
conversion
and
multimodal
functionalities
by
adjusting
excited
energy
dissipation.
Advanced Materials,
Год журнала:
2021,
Номер
33(18)
Опубликована: Апрель 1, 2021
Abstract
The
development
of
highly
efficient,
multifunctional,
and
biocompatible
sonosensitizer
is
still
a
priority
for
current
sonodynamic
therapy
(SDT).
Herein,
defect‐rich
Ti‐based
metal–organic
framework
(MOF)
(D‐MOF(Ti))
with
greatly
improved
sonosensitizing
effect
simply
constructed
used
enhanced
SDT.
Compared
the
commonly
TiO
2
,
D‐MOF(Ti)
results
in
superior
reactive
oxygen
species
(ROS)
yield
under
ultrasound
(US)
irradiation
due
to
its
narrow
bandgap,
which
principally
improves
US‐triggered
electron–hole
separation.
Meanwhile,
existence
Ti
3+
ions,
also
exhibits
high
level
Fenton‐like
activity
enable
chemodynamic
therapy.
Particularly,
US
as
excitation
source
SDT
can
simultaneously
enhance
reaction
achieve
remarkably
synergistic
outcomes
oncotherapy.
More
importantly,
be
degraded
metabolized
out
body
after
completion
therapeutic
functions
without
off‐target
toxicity.
Overall,
this
work
identifies
novel
Ti‐familial
harboring
great
potential
cancer
Aggregate,
Год журнала:
2021,
Номер
2(1), С. 95 - 113
Опубликована: Янв. 22, 2021
Abstract
Phototheranostics
that
concurrently
and
complementarily
integrate
real‐time
diagnosis
in
situ
therapeutic
capabilities
one
platform
has
become
the
advancing
edge
of
precision
medicine.
Organic
agents
possess
merits
facile
preparation,
high
purity,
tunable
photophysical
property,
good
biocompatibility,
potential
biodegradability,
which
have
shown
great
promise
for
disease
theranostics.
This
review
summarizes
recent
achievements
organic
phototheranostic
applications,
especially
rationally
utilize
energy
dissipation
pathways
Jablonski
diagram
to
modulate
fluorescence
emission,
photoacoustic/photothermal
production,
photodynamic
processes.
Of
particular
interest
are
systems
exhibiting
huge
differences
aggregate
state
as
compared
with
solution
or
single
molecule
form,
during
intramolecular
motions
play
an
important
role
regulating
properties.
The
advances
from
such
aspect
biomedical
applications
including
high‐resolution
imaging,
activatable
imaging
therapy,
adaptive
theranostics,
image‐guided
surgery,
immunotherapy,
afterglow
discussed.
A
brief
summary
perspective
this
field
also
presented.
We
hope
will
be
helpful
researchers
interested
bioprobe
design
theranostic
inspire
new
insights
into
linkage
between
science
field.
ACS Nano,
Год журнала:
2023,
Номер
17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Chemical Reviews,
Год журнала:
2022,
Номер
122(6), С. 6850 - 6918
Опубликована: Март 2, 2022
Photoacoustic
(PA)
imaging
technology,
a
three-dimensional
hybrid
modality
that
integrates
the
advantage
of
optical
and
acoustic
imaging,
has
great
application
prospects
in
molecular
due
to
its
high
depth
resolution.
To
endow
PA
with
ability
for
real-time
visualization
precise
biomedical
diagnosis,
numerous
activatable
probes
which
can
specifically
alter
their
intensities
upon
reacting
targets
or
biological
events
interest
have
been
developed.
This
review
highlights
recent
developments
applications
including
detection
biotargets
events.
First,
generation
mechanism
signals
will
be
given,
followed
by
brief
introduction
contrast
agents
used
probe
design.
Then
we
particularly
summarize
general
design
principles
alteration
strategies
developing
probes.
Furthermore,
give
detailed
discussion
living
systems.
At
last,
current
challenges
outlooks
future
discussed.
We
hope
this
stimulate
new
ideas
explore
potentials
future.
Advanced Materials,
Год журнала:
2021,
Номер
33(22)
Опубликована: Апрель 26, 2021
Multimodal
therapy
is
attracting
increasing
attention
to
improve
tumor
treatment
efficacy,
but
generally
requires
various
complicated
ingredients
combined
within
one
theranostic
system
achieve
multiple
functions.
Herein,
a
multifunctional
nanoplatform
based
on
single
aggregation-induced-emission
luminogen
(AIEgen),
DDTB,
designed
integrate
near-infrared
(NIR)
fluorescence,
photothermal,
photodynamic,
and
immunological
effects.
Intravenously
injected
AIEgen-based
nanoparticles
can
efficiently
accumulate
in
tumors
with
NIR
fluorescence
provide
preoperative
diagnosis.
Most
of
the
are
excised
under
intraoperative
navigation,
whereafter,
some
microscopic
residual
completely
ablated
by
photodynamic
photothermal
therapies
for
maximally
killing
cells
tissues.
Up
90%
survival
rate
be
achieved
this
synergistic
image-guided
surgery
therapies.
Importantly,
nanoparticles-mediated
photothermal/photodynamic
plus
programmed
death-ligand
1
antibody
significantly
induce
elimination
enhancing
effect
immunotherapy.
This
strategy
basis
AIEgen
improves
cancer
mice
maximized
therapeutic
outcomes,
holds
great
promise
clinical
treatment.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(16), С. 5607 - 5651
Опубликована: Янв. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.
Photodynamic
therapy
(PDT)
has
long
been
recognized
to
be
a
promising
approach
for
cancer
treatment.
However,
the
high
oxygen
dependency
of
conventional
PDT
dramatically
impairs
its
overall
therapeutic
efficacy,
especially
in
hypoxic
solid
tumors.
Exploration
distinctive
strategy
involving
both
high-performance
less-oxygen-dependent
photosensitizers
(PSs)
and
prominent
drug
delivery
system
is
an
appealing
yet
significantly
challenging
task.
Herein,
precise
nuclear
targeting
protocol
based
on
type-I
PSs
with
aggregation-induced
emission
(AIE)
characteristics
fabricated
first
time.
Of
two
synthesized
AIE
PSs,
TTFMN
demonstrated
exhibit
superior
property
stronger
reactive
species
(ROS)
generation
efficiency
owing
introduction
tetraphenylethylene
smaller
singlet-triplet
energy
gap,
respectively.
With
aid
lysosomal
acid-activated
TAT-peptide-modified
amphiphilic
polymer
poly(lactic
acid)12k-poly(ethylene
glycol)5k-succinic
anhydride-modified
TAT,
corresponding
TTFMN-loaded
nanoparticles
accompanied
acid-triggered
peculiarity
can
quickly
accumulate
tumor
site,
effectively
generate
ROS
region
suppress
growth
under
white
light
irradiation
minimized
systematic
toxicity.
This
delicate
"Good
Steel
Used
Blade"
tactic
maximizes
efficacy
offers
conceptual
while
practical
paradigm
optimized
treatment
further
translational
medicine.