Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405

Опубликована: Июль 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Язык: Английский

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BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Год журнала: 2022, Номер 35(18)

Опубликована: Ноя. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Язык: Английский

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Anti‐Quenching NIR‐II J‐Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics

Advanced Materials, Год журнала: 2023, Номер 35(20)

Опубликована: Март 3, 2023

Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used construct long-wavelength NIR-II emitters as optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, wide applications in fluorescence imaging impeded by limited varieties of J-type backbone serious quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) anti-quenching effect is reported highly efficient phototheranostics. The BT manipulated have Stokes shift over 400 nm aggregation-induced (AIE) property conquering self-quenching issue fluorophores. Upon BT6 assemblies an aqueous environment, absorption 800 1000 boosted more than 41 26 folds, respectively. In vivo visualization whole-body blood vessel imaging-guided phototherapy results verify that NPs agent cancer This work develops strategy precisely properties biomedical applications.

Язык: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Год журнала: 2022, Номер 476, С. 214908 - 214908

Опубликована: Ноя. 7, 2022

Язык: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 197, С. 114821 - 114821

Опубликована: Апрель 9, 2023

Язык: Английский

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“Trojan Horse” Phototheranostics: Fine‐Engineering NIR‐II AIEgen Camouflaged by Cancer Cell Membrane for Homologous‐Targeting Multimodal Imaging‐Guided Phototherapy

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Май 11, 2023

Multimodal phototheranostics on the basis of a single molecule with one-for-all characteristics represents convenient approach for effective cancer treatment. In this report, versatile featured by aggregation-induced emission, namely DHTDP, synchronously enabling second near-infrared (NIR-II) fluorescence emission and efficient photothermal conversion is developed elaborate structural modulation. By camouflaging DHTDP nanoparticles cell membrane, resultant biomimetic exhibit significantly both facilitated delivery efficiency homologous targeting capability, afford precise imaging guidance maximize therapeutic outcomes in form NIR-II (FLI)-photoacoustic (PAI)-photothermal (PTI) trimodal imaging-guided therapy (PTT). This study presents first example multimodal loaded homogeneity-targeting thus brings new insight into exploration superior practical theranostics.

Язык: Английский

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State-of-the-art self-luminescence: a win–win situation

Chemical Society Reviews, Год журнала: 2022, Номер 51(21), С. 8815 - 8831

Опубликована: Янв. 1, 2022

Self-luminescence, which eliminates the real-time external optical excitation, can effectively avoid background autofluorescence in photoluminescence, endowing with ultrahigh signal-to-noise ratio and sensitivity bioassay. Furthermore, situ generated emitted photons have been applied to develop excitation-free diagnostics therapeutic agents against deeply seated diseases. "Enhanced" self-luminescence, referring aggregation-induced emission (AIE)-integrated self-luminescence systems, is endowed not only above merits but also other superiorities including stronger luminous brightness longer half-life compared "traditional" platforms. As an emerging booming hotspot, "enhanced" facilitated by win-win cooperation of self-luminescent techniques has become a powerful tool for interdisciplinary research. This tutorial review summarizes advancements AIE-assisted chemiluminescence afterglow imaging, starting from discussion on design working principles, luminescent mechanisms fuels, versatile integrated approaches advantages, broad range representative examples biosensors oncotherapy. Finally, current challenges perspectives are discussed further actuate development biomedical diagnosis treatment.

Язык: Английский

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Rational Design of Polymethine Dyes with NIR‐II Emission and High Photothermal Conversion Efficiency for Multimodal‐Imaging‐Guided Photo‐Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(12)

Опубликована: Янв. 11, 2023

Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis therapeutic meet the demands of precision medicine. The information effect are directly determined by fluorescence imaging ability photothermal conversion efficiency (PCE) phototheranostic agents. Hence, how balance competitive radiative nonradiative processes agents is key factor evaluate effect. Herein, molecules named ICRs with high photostaibility rationally designed, exhibiting emission in second near-infrared window (NIR-II, 1000-1700 nm) PCE, which related strong donor-acceptor (D-A) interaction reorganization energy Noteworthily, ICR-Qu stronger D-A large-sized conjugated unit encapsulated nanoparticles exhibits PCE (81.1%). In addition, ICR-QuNPs used (FLI), photoacoustic (PAI), (PTI) guide deep-tissue photonic hyperthermia, achieving removal inhibition breast cancer. Furthermore, combined α-PD-1, show huge potential be facile efficient tool photo-immunotherapy. More importantly, this study not only reports an "all-in-one" polymethine-based agent, but also sheds light on exploration versatile organic future practical applications.

Язык: Английский

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A Water‐Soluble AIEgen for Noninvasive Diagnosis of Kidney Fibrosis via SWIR Fluorescence and Photoacoustic Imaging

Advanced Materials, Год журнала: 2022, Номер 34(50)

Опубликована: Окт. 12, 2022

Early diagnosis of renal fibrosis is crucially significant on account its worldwide prevalent tendency. Optical imaging in the near-infrared window has been recognized as an appealing technique for timely detection dysfunction. However, formulating a contrast agent that allows early monitoring and concurrently renally clearable normal group still challenging. Herein, nanosized fluorophore with aggregation-induced emission (AIE) features, namely AIE-4PEG550 NPs, well-tailored amenable to longitudinal visualization progression specifically early-stage via short-wave infrared (SWIR, 900-1700 nm) fluorescence photoacoustic bimodal imaging. The small size (≈26 nm), filtrable molecular weight (3.3 kDa), high clearance efficiency (93.1 ± 1.7% excretion through kidneys within 24 h), outstanding performance, good biocompatibility, together make NPs remarkably impressive far superior clinical diagnostic assays. finding this study would provide blueprint next generation agents extent fibrosis.

Язык: Английский

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Full‐Color Emissive D‐D‐A Carbazole Luminophores: Red‐to‐NIR Mechano‐fluorochromism, Aggregation‐Induced Near‐Infrared Emission, and Application in Photodynamic Therapy

Chemistry - A European Journal, Год журнала: 2022, Номер 29(11)

Опубликована: Дек. 22, 2022

The preparation of multifunctionalized luminophores with full-color emission based on an identical core skeleton is a significative but challenging research topic. In this work, eight donor-donor-acceptor (D-D-A)-type luminogens central carbazole bearing C6 hydrocarbon chain were designed by using different kinds donor and acceptor units the left right, synthesized in good yields. These D-D-A derivatives display deep-blue, sky-blue, cyan, green, yellow-green, yellow, orange red fluorescence solid state, achieving covering whole visible light range under UV illumination. Notably, dicyano-functionalized triphenylamine-containing derivative exhibits rare aggregation-induced near-infrared red-to-near-infrared mechano-fluorochromism high contrast beyond 100 nm. Furthermore, red-emissive luminogen can serve as potential candidate for cell imaging photodynamic therapy (PDT). This work not only provides reference construction emissive systems also opens new avenue to capable simultaneous application near-Infrared mechanical-force sensors PDT fields.

Язык: Английский

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