Guest-host doped strategy for constructing ultralong-lifetime near-infrared organic phosphorescence materials for bioimaging

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Янв. 10, 2022

Abstract Organic near-infrared room temperature phosphorescence materials have unparalleled advantages in bioimaging due to their excellent penetrability. However, limited by the energy gap law, (>650 nm) are very rare, moreover, lifetimes of these short. In this work, we obtained organic with long wavelengths (600/657–681/732 and (102–324 ms) for first time through guest-host doped strategy. The guest molecule has sufficient conjugation reduce lowest triplet level host assists exciton transfer inhibits non-radiative transition excitons. These exhibit good tissue penetration bioimaging. Thanks characteristic lifetime wavelength emissive materials, tumor imaging living mice a signal background ratio value as high 43 is successfully realized. This work provides practical solution construction both lifetimes.

Язык: Английский

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Recent Advances on Host–Guest Material Systems toward Organic Room Temperature Phosphorescence

Small, Год журнала: 2021, Номер 18(1)

Опубликована: Ноя. 1, 2021

Abstract The design and characterization of purely organic room‐temperature phosphorescent (RTP) materials for optoelectronic applications is currently the focus research in field electronics. Particularly, with merits preparation controllability modulation flexibility, host–guest material systems are encouraging candidates that can prepare high‐performance RTP materials. By regulating interaction between host guest molecules, it effectively control quantum efficiency, luminescent lifetime, color materials, even produce emission stimuli‐responsive features, holding tremendous potential diverse such as encryption anti‐counterfeiting, light‐emitting diodes, sensing, optical recording, etc. Here a roundup rapid achievement construction strategies, molecule systems, diversity outlined. Intrinsic correlations molecular properties survey recent significant advances development divided into three including rigid matrix, exciplex, sensitization presented. Providing an insightful understanding offering promising platform high throughput screening inherent advantages simple preparation, low‐cost, versatile resource, controllably modulated wide range intended.

Язык: Английский

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Molecular Probes for Autofluorescence-Free Optical Imaging

Chemical Reviews, Год журнала: 2021, Номер 121(21), С. 13086 - 13131

Опубликована: Сен. 24, 2021

Optical imaging is an indispensable tool in clinical diagnostics and fundamental biomedical research. Autofluorescence-free optical imaging, which eliminates real-time excitation to minimize background noise, enables clear visualization of biological architecture physiopathological events deep within living subjects. Molecular probes especially developed for autofluorescence-free have been proven remarkably improve the sensitivity, penetration depth, target specificity, multiplexing capability. In this Review, we focus on advancements molecular through lens particular or photophysical mechanisms that produce long-lasting luminescence after cessation light excitation. The versatile design strategies these are discussed along with a broad range applications. Finally, challenges perspectives further advance next-generation vivo vitro biosensors.

Язык: Английский

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Supramolecular Purely Organic Room-Temperature Phosphorescence

Accounts of Chemical Research, Год журнала: 2021, Номер 54(17), С. 3403 - 3414

Опубликована: Авг. 17, 2021

ConspectusIn recent years, purely organic room-temperature phosphorescence (RTP) has aroused wide concern and promotes the development of supramolecular phosphorescence. Different from crystallization, polymerization, or matrix rigidification, strategy mainly takes advantage synergy between co-assembly strong binding by macrocyclic host compounds (cucurbit[n]urils, cyclodextrins, etc.) to overcome deficiencies such as poor processability water solubility improves RTP materials' quantum efficiency lifetime in solid state an aqueous solution. Meanwhile, it expands application, especially solution, cell imaging. Therefore, will become a new growth point have broad application prospects chemistry, biology, material science.This Account focuses on uniquely synergetic advantages host–guest interaction hosts for enhancing RTP. This starts with brief introduction materials well co-assembly. Then, we introduce solid-state involving ultrahigh phosphorescent yield via tight encapsulation cucurbit[6]uril, ultralong changing substituents phosphors, long-lived bright polymerization. applications anti-counterfeiting data encryption are presented. The third part be water-phase systems constructed water-soluble cucurbit[8]uril. Host–guest polymerization worked together toward efficient multi-stage assembly promoted targeted imaging energy transfer. A humidity sensor conversion hydrogels xerogels also involved. In summary section, present perspectives possible research directions phosphorescence.Furthermore, basis previous research, would like conclude propose developing concept "macrocycles enhance guest's phosphorescence", this not only means that limits movement guest compound interactions but involves enhancement centered which further RTP, solubility, biocompatibility. And believe able, theory "assembly-induced emission" "aggregation-induced emission", accelerate materials.

Язык: Английский

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Achieving Efficient NIR‐II Type‐I Photosensitizers for Photodynamic/Photothermal Therapy upon Regulating Chalcogen Elements

Advanced Materials, Год журнала: 2021, Номер 34(7)

Опубликована: Дек. 22, 2021

Second near-infrared (NIR-II) window type-I photosensitizers have intrinsic advantages in photodynamic/photothermal therapy (PDT/PTT) of some malignant tumors with deep infiltration, large size, complicated location, and low possibility surgery/radiotherapy. Herein, three chalcogen-element-based donor-acceptor-type semiconducting polymers (poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4″H)-dione)-alt-2,5-(thiophene)] (PTS), poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4″H)-dione)-alt-2,5-(selenophene)] (PTSe), poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4'H)-dione)-alt-2,5-(tellurophene)] (PTTe)) are synthesized fully characterized, demonstrating strong absorption the NIR-II region. Upon adjusting chalcogen elements, intramolecular charge-transfer characteristics heavy-atom effect tuned to enhance intersystem crossing rate, improving photodynamic effect. Moreover, energy levels Gibbs free energies facilitate process. As a result, PTTe nanoparticles (NPs) produce superoxide anion radicals (O2•- ) more efficiently demonstrate higher photothermal conversion efficiency than PTS PTSe NPs upon (1064 nm) laser irradiation, exhibiting unprecedented PDT/PTT performance vitro vivo. This work provides ideas for achieving high-performance hypoxic oncotherapy.

Язык: Английский

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Activating Room‐Temperature Phosphorescence of Organic Luminophores via External Heavy‐Atom Effect and Rigidity of Ionic Polymer Matrix**

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(36), С. 19735 - 19739

Опубликована: Июль 9, 2021

Abstract Pure organic room‐temperature phosphorescence (RTP) materials have attracted wide attention for their easy preparation, low toxicity, and applications in various fields like bioimaging anti‐counterfeiting. Developing phosphorescent systems with more universality less difficulty synthesis has long been the pursuit of scientists. By employing a polymeric quaternary ammonium salt an ionic bonding matrix heavy atoms, commercial fluorescent dyes are directly endowed emission. In single amorphous polymer, external heavy‐atom effect generates excited triplet states rigid polymer stabilizes them. This study put forward new general strategy to design develop pure RTP starting from existing library without complicated chemical synthesis.

Язык: Английский

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On-demand modulating afterglow color of water-soluble polymers through phosphorescence FRET for multicolor security printing

Science Advances, Год журнала: 2022, Номер 8(15)

Опубликована: Апрель 15, 2022

Developing full-color organic ultralong room temperature phosphorescence (OURTP) materials with continuously variable afterglow emission is of considerable practical importance in diverse optoelectronic applications but remains a formidable challenge. Here, we present an effective strategy for on-demand engineering color water-soluble polymeric systems via efficient Förster resonance energy transfer. Using blue emitting polymer as host and series fluorescent emitters varied emissive colors guests, rationally modulated, conferring the ranging from to red even white lifetimes up 4.2 s photoluminescence quantum yields 36%.These multicolor-emitting can function OURTP security inks, multilevel information encryption was successfully established by RGB-based multicolor printing. These results important guidance developing high-performance polymers tuning ability remarkable applications.

Язык: Английский

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Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

ACS Nano, Год журнала: 2022, Номер 16(3), С. 4162 - 4174

Опубликована: Март 1, 2022

Tumor hypoxia seriously impairs the therapeutic outcomes of type II photodynamic therapy (PDT), which is highly dependent upon tissue oxygen concentration. Herein, a facile strategy acceptor planarization and donor rotation proposed to design I photosensitizers (PSs) photothermal reagents. Acceptor can not only enforce intramolecular charge transfer redshift NIR absorption but also PSs from photochemical pathways. Donor optimizes conversion efficiency (PCE). Accordingly, three 3,6-divinyl-substituted diketopyrrolopyrrole (DPP) derivatives, 2TPAVDPP, TPATPEVDPP, 2TPEVDPP, with different number rotors were prepared. Experimental results showed that compounds excellent PSs, corresponding 2TPEVDPP nanoparticles (NPs) most possessed highest PCE. The photophysical properties NPs are particularly suitable for in vivo fluorescence imaging-guided synergistic PDT/PTT therapy. helpful exploiting phototherapeutic reagents high efficacy PDT PTT.

Язык: Английский

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Light‐Harvesting Supramolecular Phosphors: Highly Efficient Room Temperature Phosphorescence in Solution and Hydrogels

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(36), С. 19720 - 19724

Опубликована: Июнь 30, 2021

Abstract Solution phase room‐temperature phosphorescence (RTP) from organic phosphors is seldom realized. Herein we report one of the highest quantum yield solution state RTP (ca. 41.8 %) in water, a structurally simple phthalimide phosphor, by employing an organic–inorganic supramolecular scaffolding strategy. We further use these hybrid as light‐harvesting scaffold to achieve delayed fluorescence orthogonally anchored Sulforhodamine acceptor dyes via efficient triplet singlet Förster resonance energy transfer (TS‐FRET), which rarely achieved solution. Electrostatic cross‐linking inorganic at higher concentrations facilitates formation self‐standing hydrogels with and energy‐transfer mediated long‐lived fluorescence.

Язык: Английский

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Recent advances in the design of afterglow materials: mechanisms, structural regulation strategies and applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(22), С. 8005 - 8058

Опубликована: Янв. 1, 2023

Afterglow materials have attracted widespread attention owing to their distinctive and long-lived optical emission properties which create exciting opportunities in various fields.

Язык: Английский

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