Fe₃O₄/Ag/Bi₂MoO₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(52)

Опубликована: Окт. 9, 2021

Abstract Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of current are limited and their efficiency is usually compromised not sustainable in tumor microenvironment (TME). Therefore, combination involving additional therapeutics often necessary resulting complication may jeopardize practical feasibility. Herein, an unprecedented “all‐in‐one” Fe 3 O 4 /Ag/Bi 2 MoO 6 nanoparticle (FAB NP) rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal with guidance by magnetic resonance, photoacoustic, imaging. Based its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) photodynamic property, cascaded nanocatalytic reactions enabled sustained TME for outstanding therapeutic outcomes. The working mechanisms underlying intraparticulate interactions, sustainability, self‐replenishment arising from coupling between carefully revealed, providing new insights into design novel high efficiency, good specificity, low side effects.

Язык: Английский

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Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells

Advanced Science, Год журнала: 2021, Номер 8(22)

Опубликована: Окт. 10, 2021

Abstract Ferroptosis is a new form of regulated cell death, which characterized by the iron‐dependent accumulation lethal lipid peroxides and involved in many critical diseases. Recent reports revealed that cellular energy metabolism activities such as glycolysis, pentose phosphate pathway (PPP), tricarboxylic acid cycle are regulation key ferroptosis markers reduced nicotinamide adenine dinucleotide (NADPH), glutathione (GSH), reactive oxygen species (ROS), therefore imposing potential regulatory roles ferroptosis. Remarkably, tumor cells can activate adaptive metabolic responses to inhibit for self‐preservation upregulation glycolysis PPP. Due rapid proliferation intensified rate, has become target disrupting redox homeostasis induce Based on these emerging insights, impact those‐tumor specific aberrations systematically characterized, rewired glucose compensation through glutamine utilization analyzed underlying molecular mechanisms. Additionally, those ferroptosis‐based therapeutic strategies also discussed exploiting vulnerabilities, may open up avenues treatment clinical context.

Язык: Английский

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Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Advanced Healthcare Materials, Год журнала: 2021, Номер 11(2)

Опубликована: Ноя. 9, 2021

Abstract Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal are developed used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton‐like reaction generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O ) kill cells, which displays promising potentials for treatment. However, the low catalytic efficiency off‐target side effects limit biomedical application CDT. In this regard, various strategies implemented potentiate against tumor, retrofitting microenvironment (e.g., increasing H level, decreasing reductive substances, reducing pH), enhancing nanocatalysts, other strategies. This review aims summarize development these recent progresses nanocatalyst‐mediated antitumor application. The future trend challenges also discussed.

Язык: Английский

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Tumor‐Microenvironment‐Responsive Cascade Reactions by a Cobalt‐Single‐Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(48)

Опубликована: Авг. 16, 2022

Nanocatalytic therapy, involving the nanozyme-triggered production of reactive oxygen species (ROS) in tumor microenvironment (TME), has demonstrated potential but nanozymes still face challenges activity and specificity that compromise therapeutic efficacy. Herein, we report a strategy based on single-atom nanozyme to initiate cascade enzymatic reactions TME for tumor-specific treatment. The cobalt-single-atom nanozyme, with Co-N coordination N-doped porous carbon (Co-SAs@NC), displays catalase-like decomposes cellular endogenous H2 O2 produce , subsequent oxidase-like converts into cytotoxic superoxide radicals efficiently kill cells. By incorporation doxorubicin, therapy achieves significantly enhanced antitumor effect vivo. Our findings show TME-specific catalytic combined chemotherapy is promising efficient therapy.

Язык: Английский

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A Metabolic Multistage Glutathione Depletion Used for Tumor-Specific Chemodynamic Therapy

ACS Nano, Год журнала: 2022, Номер 16(3), С. 4228 - 4238

Опубликована: Фев. 25, 2022

The high glutathione (GSH) content in tumor cells strongly affects the efficiency of chemodynamic therapy (CDT). Despite devoted efforts, it still remains a formidable challenge for manufacturing tumor-specific CDT with rapid and thorough depletion GSH. Herein, multistage GSH-consuming is presented. By consuming reserved GSH inhibiting both raw materials energy supply synthesis cancer cells, achieves highly potent exhaustion. Our used glycolysis inhibitor cuts off specific to increase sensitivity CDT. Furthermore, starvation effect can stimulate protective mode normal cells. Since nanocarrier are responsive microenvironment, this makes more selective work not only fabricates nanomedicine exhausted function but also uses metabolic differences achieve therapy.

Язык: Английский

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Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy

Coordination Chemistry Reviews, Год журнала: 2023, Номер 481, С. 215049 - 215049

Опубликована: Фев. 9, 2023

Язык: Английский

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A Titanium Nitride Nanozyme for pH‐Responsive and Irradiation‐Enhanced Cascade‐Catalytic Tumor Therapy

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(48), С. 25328 - 25338

Опубликована: Авг. 28, 2021

Nanozyme-based catalytic tumor therapy is an emerging therapeutic method with high reactivity in response to microenvironments (TMEs). To overcome the current limitations of deficient activity nanozymes, we studied contributing factors enzymatic based on non-metallic-atom doping and irradiation. Nitrogen significantly enhanced peroxidase Ti-based which was shown experimentally theoretically. Based excellent NIR-adsorption-induced surface plasmon resonance photothermal effect, TiN nanoparticles (NPs) further improved under NIR laser Hence, acidic TME-responsive irradiation-mediated cascade nanocatalyst (TLGp) presented by using TiN-NP-encapsulated liposomes linked pH-responsive PEG-modified glucose oxidase (GOx). The integration GOx-mediated H2 O2 self-supply, nitrogen-doping, irradiation-enhanced NPs mild-photothermal enables effective inhibition TLGp minimal side effects vivo.

Язык: Английский

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Recent advances of redox-responsive nanoplatforms for tumor theranostics

Journal of Controlled Release, Год журнала: 2021, Номер 332, С. 269 - 284

Опубликована: Март 1, 2021

Язык: Английский

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Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Advanced Functional Materials, Год журнала: 2021, Номер 31(50)

Опубликована: Сен. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Язык: Английский

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A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

Small, Год журнала: 2021, Номер 17(32)

Опубликована: Июль 3, 2021

Chemodynamic therapy (CDT), which induces cell death by decomposing high levels of H2 O2 in tumor cells into highly toxic ·OH, is recognized as a promising antineoplastic approach. However, current CDT approaches are often restricted the controlled and upregulated cellular antioxidant defense. To enhance ·OH-induced damage CDT, covalent organic framework (COF)-based, ferrocene (Fc)- glutathione peroxidase 4 (GPX4) inhibitor-loaded nanodrug, RSL3@COF-Fc (2b), fabricated. The obtained 2b not only promotes situ Fenton-like reactions to trigger ·OH production cells, but also attenuates repair mechanisms under oxidative stress via irreversible GPX4 inhibition. As result, these two synergistically result massive lipid peroxide accumulation, subsequent damage, ultimately ferroptosis, while being limited intracellular glutathione. It believed that this research provides paradigm for enhancing reactive oxygen species-mediated oncotherapy through redox dyshomeostasis may provide new insights developing COF-based nanomedicine.

Язык: Английский

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