Advanced Materials,
Год журнала:
2022,
Номер
35(7)
Опубликована: Ноя. 22, 2022
Overcoming
apoptosis
resistance
to
achieve
efficient
breast
cancer
treatment
remains
a
challenge.
The
precise
induction
of
another
form
programmed
cell
death,
pyroptosis,
is
an
excellent
alternative
for
treating
cancer.
Ultrasound
(US)-enhanced
enzyme
dynamic
(enzyodynamic)
therapy
developed
by
employing
LaFeO3
(LFO)
perovskite
nanocrystals
as
substrate
increase
the
rate
deleterious
reactive
oxygen
species
(ROS)
generation
intensive
pyroptosis.
LFO
possess
quadruple
enzyme-mimicking
activities,
including
oxidase-,
peroxidase-,
glutathione
and
catalase-mimicking
which
undertake
dominant
therapeutic
task
through
cascade
catalytic
reactions,
reversal
hypoxic
microenvironment,
depletion
endogenous
glutathione,
continuous
output
ROS.
US
exogenous
stimulation
increases
transition
intermediate
complex
Fe
(II)
favors
incremental
ROS
production,
burst-induced
pyroptosis
process
accomplished
ROS-TXNIP-NLRP3-GSDMD
pathway.
Both
in
vitro
vivo
antineoplastic
outcomes
affirm
ascendancy
nanozyme-induced
This
work
highlights
critical
role
coupled
with
nanocatalytic
reactors
pyroptosis-dominant
circumvention
feature.
Recent
investigations
reveal
that
lactate
is
not
a
waste
product
but
major
energy
source
for
cells,
especially
in
the
mitochondria,
which
can
support
cellular
survival
under
glucose
shortage.
Accordingly,
new
understanding
of
prompts
to
target
it
together
with
pursue
more
efficient
cancer
starvation
therapy.
Herein,
zeolitic
imidazolate
framework-8
(ZIF-8)
nanoplatforms
are
used
co-deliver
α-cyano-4-hydroxycinnamate
(CHC)
and
oxidase
(GOx)
fulfill
task
simultaneous
depriving
glucose,
resulting
nanomedicine
CHC/GOx@ZIF-8.
The
synthesis
conditions
carefully
optimized
order
yield
monodisperse
uniform
nanomedicines,
will
ensure
reliable
steady
therapeutic
properties.
Compared
strategies
aiming
at
single
carbon
source,
improved
therapy
efficacy
observed.
Besides,
than
boosting
shortage,
CHC/GOx@ZIF-8
block
lactate-fueled
respiration
relieve
solid
tumor
hypoxia,
enhance
GOx
catalysis
activity,
depleting
extra
producing
cytotoxic
H2
O2
.
By
synergistically
enhanced
anti-tumor
effect,
both
vitro
vivo
cancer-killing
efficacies
show
twice
enhancements
mediated
results
demonstrate
dual-depriving
advanced
strategy
strengthening
ACS Applied Materials & Interfaces,
Год журнала:
2021,
Номер
13(37), С. 43925 - 43936
Опубликована: Сен. 9, 2021
Chemodynamic
therapy
(CDT)
that
utilizes
Fenton-type
reactions
to
convert
endogenous
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(•OH)
is
a
promising
strategy
in
anticancer
treatment,
but
the
overexpression
of
glutathione
(GSH)
and
limited
H2O2
make
efficiency
CDT
unsatisfactory.
Here,
an
intelligent
nanoplatform
CuO2@mPDA/DOX-HA
(CPPDH),
which
induced
depletion
GSH
self-supply
H2O2,
was
proposed.
When
CPPDH
entered
tumor
cells
through
targeting
effect
hyaluronic
acid
(HA),
release
Cu2+
produced
were
triggered
by
acidic
environment
lysosomes.
Then,
reduced
Cu+,
Cu+
catalyzed
produce
•OH.
The
generation
•OH
could
be
distinctly
enhanced
self-sufficiency.
Besides,
outstanding
photothermal
(PTT)
stimulated
NIR
irradiation
on
mesoporous
polydopamine
(mPDA).
Meanwhile,
mPDA
excellent
photoacoustic
reagent,
monitor
delivery
nanocomposite
materials
(PA)
imaging.
Moreover,
successful
doxorubicin
(DOX)
realized
integration
chemotherapy,
PTT,
CDT.
This
solve
problem
insufficient
efficacy
caused
GSH.
multifunctional
may
open
broad
path
for
self-boosting
synergistic
therapy.
Advanced Materials,
Год журнала:
2021,
Номер
34(12)
Опубликована: Дек. 13, 2021
The
clinical
employment
of
cisplatin
(cis-diamminedichloroplatinum(II)
(CDDP))
is
largely
constrained
due
to
the
non-specific
delivery
and
resultant
serious
systemic
toxicity.
Small-sized
biocompatible
biodegradable
hollow
mesoporous
organosilica
(HMOS)
nanoparticles
show
superior
advantages
for
targeted
CDDP
but
suffer
from
premature
leakage.
Herein,
smart
use
a
bimetallic
Zn2+
/Cu2+
co-doped
metal-organic
framework
(MOF)
made
block
pores
HMOS
preventing
potential
leakage
remarkably
increasing
loading
capacity
HMOS.
Once
reaching
acidic
tumor
microenvironment
(TME),
outer
MOF
can
decompose
quickly
release
chemotherapy
against
cancer.
Besides,
concomitant
dopant
Cu2+
deplete
intracellular
glutathione
(GSH)
increased
toxicity
as
well
catalyzing
decomposition
intratumoral
H2
O2
into
highly
toxic
•OH
chemodynamic
therapy
(CDT).
Moreover,
substantially
reduced
GSH
also
protect
yielded
scavenging
thus
greatly
improve
•OH-based
CDT
effect.
In
addition
providing
hybrid
HMOS@MOF
nanocarrier,
this
study
expected
establish
new
form
TME-unlocked
nanoformula
efficient
tumor-specific
GSH-depletion-enhanced
synergistic
chemotherapy/chemodynamic
therapy.
Advanced Materials,
Год журнала:
2022,
Номер
35(7)
Опубликована: Ноя. 22, 2022
Overcoming
apoptosis
resistance
to
achieve
efficient
breast
cancer
treatment
remains
a
challenge.
The
precise
induction
of
another
form
programmed
cell
death,
pyroptosis,
is
an
excellent
alternative
for
treating
cancer.
Ultrasound
(US)-enhanced
enzyme
dynamic
(enzyodynamic)
therapy
developed
by
employing
LaFeO3
(LFO)
perovskite
nanocrystals
as
substrate
increase
the
rate
deleterious
reactive
oxygen
species
(ROS)
generation
intensive
pyroptosis.
LFO
possess
quadruple
enzyme-mimicking
activities,
including
oxidase-,
peroxidase-,
glutathione
and
catalase-mimicking
which
undertake
dominant
therapeutic
task
through
cascade
catalytic
reactions,
reversal
hypoxic
microenvironment,
depletion
endogenous
glutathione,
continuous
output
ROS.
US
exogenous
stimulation
increases
transition
intermediate
complex
Fe
(II)
favors
incremental
ROS
production,
burst-induced
pyroptosis
process
accomplished
ROS-TXNIP-NLRP3-GSDMD
pathway.
Both
in
vitro
vivo
antineoplastic
outcomes
affirm
ascendancy
nanozyme-induced
This
work
highlights
critical
role
coupled
with
nanocatalytic
reactors
pyroptosis-dominant
circumvention
feature.
