Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 6891 - 6952

Опубликована: Май 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Язык: Английский

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Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Год журнала: 2022, Номер 9(22)

Опубликована: Июнь 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Язык: Английский

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Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 209 - 268

Опубликована: Окт. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Язык: Английский

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Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(2), С. 787 - 797

Опубликована: Янв. 5, 2022

Tumor-derived exosome can suppress dendritic cells (DCs) and T functions. Excessive secretion of exosomal programmed death-ligand 1 (PD-L1) results in therapeutic resistance to PD-1/PD-L1 immunotherapy clinical failure. Restored by antiexosomal PD-L1 tactic intensify ferroptosis tumor vice versa. Diminishing suppression establishing a nexus may rescue the discouraging antitumor immunity. Here, we engineered phototheranostic metal-phenolic networks (PFG MPNs) an assembly semiconductor polymers encapsulating inducer (Fe3+) inhibitor (GW4869). The PFG MPNs elicited superior near-infrared II fluorescence/photoacoustic imaging tracking performance for precise photothermal therapy (PTT). PTT-augmented immunogenic cell death relieved silencing on DC maturation. GW4869 mediated based inhibition revitalized enhanced ferroptosis. This novel synergy PTT with evoked potent immunity B16F10 tumors immunological memory against metastatic lymph nodes.

Язык: Английский

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Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(27)

Опубликована: Март 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Язык: Английский

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Cell membrane coated-nanoparticles for cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 12(8), С. 3233 - 3254

Опубликована: Фев. 28, 2022

Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of had positive effects on clinical treatment. However, is still restricted heterogeneity, immune cell disability, tumor immunosuppressive microenvironment systemic toxicity. Cell membrane-coated nanoparticles (CMCNs) inherit abundant source cell-relevant functions, including "self" markers, cross-talking biological targeting, homing to specific regions. These enable them possess preferred characteristics, better compatibility, weak immunogenicity, escaping, a prolonged circulation, targeting. Therefore, they are applied precisely deliver drugs promote effect immunotherapy. In review, we summarize latest researches biomimetic CMCNs for immunotherapy, outline existing therapies, explore unique functions molecular mechanisms various nanoparticles, analyze challenges which face in translation.

Язык: Английский

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Second Near‐Infrared Light‐Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy

Advanced Materials, Год журнала: 2021, Номер 33(36)

Опубликована: Июль 23, 2021

Immunometabolic modulation offers new opportunities to treat cancers as it is highly associated with cancer progression and immunosuppressive microenvironment. However, traditional regimens using nonselective small-molecule immunomodulators lead the off-target adverse effects insufficient therapeutic outcomes. Herein a second near-infrared (NIR-II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) for synergistic photothermal immunometabolic therapy of reported. ASPA backbone obtained by conjugating vipadenant, an antagonist adenosine A2A receptor, onto NIR-II light-absorbing polymer via azo-based thermolabile linker. Under deep-penetrating photoirradiation, induces tumor thermal ablation subsequently immunogenic cell death, triggers cleavage linker, releases block adenosinergic pathway. Such remotely controlled regulation potentiates cytotoxic T functions while suppresses regulatory activities, leading efficient primary inhibition, pulmonary metastasis prevention, long-term immunological memory. Thereby, this work provides generic approach precise spatiotemporal immunometabolism.

Язык: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Год журнала: 2022, Номер 65(6), С. 1010 - 1075

Опубликована: Апрель 24, 2022

Язык: Английский

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A Biomimetic Aggregation‐Induced Emission Photosensitizer with Antigen‐Presenting and Hitchhiking Function for Lipid Droplet Targeted Photodynamic Immunotherapy

Advanced Materials, Год журнала: 2021, Номер 33(33)

Опубликована: Июль 11, 2021

Abstract Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment that associated with an antitumor immune response. However, immunosuppression of the tumor microenvironment limits response induced by PDT. Stimulation and proliferation T cells critical step generating responses depends on efficient presentation antigens co‐stimulatory molecules antigen‐presenting (APCs). Here, biomimetic aggregation‐induced emission (AIE) photosensitizers hitchhiking abilities (DC@AIEdots) are developed coating dendritic cell (DC) membranes nanoaggregates AIEgens. Notably, inner AIE can selectively accumulate in lipid droplets cells, outer membrane facilitate DC@AIEdots onto endogenous enhance delivery efficiency about 1.6 times. Furthermore, stimulate vivo activation trigger system. The potential applications therapeutic agents targeting immunotherapy indicated new drug provided. Lastly, study presents photoactive artificial platform stimulation photodynamic immunotherapy.

Язык: Английский

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Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines

Advanced Materials, Год журнала: 2021, Номер 34(1)

Опубликована: Окт. 14, 2021

Abstract Cancer vaccines aim at eliciting tumor‐specific responses for the immune system to identify and eradicate malignant tumor cells while sparing normal tissues. Furthermore, cancer can potentially induce long‐term immunological memory antitumor responses, preventing metastasis recurrence, thus presenting an attractive treatment option in immunotherapy. However, clinical efficacy of has remained low due longstanding challenges, such as poor immunogenicity, immunosuppressive microenvironment, heterogeneity, inappropriate tolerance, systemic toxicity. Recently, bioinspired materials biomimetic technologies have emerged play a part reshaping field nanomedicine. By mimicking desirable chemical biological properties nature, engineering vaccine delivery platforms effectively transport therapeutic cargos sites, amplify antigen adjuvant bioactivities, enable spatiotemporal control on‐demand immunoactivation. As such, integration designs into enhance retaining good safety profiles, which contributes expediting translation vaccines. Recent advances vaccines, existing obstacles faced, well insights future directions are discussed here.

Язык: Английский

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