Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies

Advanced Materials, Год журнала: 2022, Номер 34(28)

Опубликована: Май 7, 2022

Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its clinical applications are hindered by "always-on" pharmacological activities therapeutic agents and lack efficient sonosensitizers. Herein, development semiconducting polymers as sonosensitizers further sono-immunotherapeutic nanobodies (SPNAb ) for activatable sono-immunotherapy reported. Conjugation anti-CTLA-4 antibodies onto polymer nanoparticles through a 1 O2 -cleavable linker affords SPNAb with relatively low CTLA-4 binding affinity. Upon sono-irradiation, generates not only to elicit effect induce immunogenic cell death, but also release trigger situ checkpoint blockade. Such synergistic action mediated modulates tumoricidal function T-cell immunity promoting proliferation cytotoxic T lymphocytes depleting immunosuppressive regulatory cells, resulting effective tumor regression, metastasis inhibition, durable immunological memory, prevention relapse. Therefore, this study represents proof-of-concept strategy using precise spatiotemporal control over immunotherapy.

Язык: Английский

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Biomedical Applications of MXenes: From Nanomedicine to Biomaterials

Accounts of Materials Research, Год журнала: 2022, Номер 3(8), С. 785 - 798

Опубликована: Июль 18, 2022

ConspectusThe rise of two-dimensional (2D) materials has led to significant interest in their potential applications for nanomedicine and biomaterials the hope that they can overcome some intrinsic limitations conventional theranostic materials. MXenes, an emerging family 2D mainly made transition metal carbides/nitrides, have drawn substantial biomedical because unique physicochemical properties. The remarkable photothermal energy-converting capability MXenes allows photonic hyperthermia treatment second near-infrared biowindow with deep tissue penetration. diverse choice elements endows them aptitudes act as contrast agents computed tomography magnetic resonance imaging. As understanding pathological characteristics is improved, desirable properties performances become more comprehensive, which unlikely be accomplished formulation alone.In this Account, we highlight recent progress ranging from biomaterials. We will start by introducing major synthetic techniques fabricating ultrathin structures nanoscale sizes purposes. then elaborate how differ other materials, showing exclusive applications. surface compositions allow tuning bandgap plasmon effect, essential nanodynamic therapy. could render enzymatic activities nanocatalytic also possess favorable biodegradability biocompatibility, facilitating clinical translation.However, might insufficient fulfill specific requirements advanced For instance, therapeutic efficiency alone would impaired reasons such low tumor accumulation nanomedicine, inclined thermal resistance cancer cells, hypoxic microenvironment. In addition, are limited therapy or theranostics. been integrated functional components tackle these issues. Thus, further discuss strategies fabricate MXene-based different dimensional a broad range applications, localized regeneration. Several methods modify demonstrated increase stability MXene physiological media. Decorating 0D nanoparticles enables combination imaging modalities. Integrating layered improved efficiency, 3D implantable discussed.

Язык: Английский

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Heterostructural Nanoadjuvant CuSe/CoSe₂ for Potentiating Ferroptosis and Photoimmunotherapy through Intratumoral Blocked Lactate Efflux

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(13), С. 7205 - 7217

Опубликована: Март 23, 2023

The desirable curative effect in clinical immunotherapy has been challenging due to the immunosuppressive tumor microenvironment (TME) with high lactic acid (LA) metabolism solid tumors. Although targeting metabolic reprogramming of cells can restore survival and function immune TME, it is also plagued by insufficient immunogenicity. Herein, an activatable immunomodulatory nanoadjuvant CuSe/CoSe2@syrosingopine (CSC@Syro) constructed for simultaneously relieving TME boosting response. Specifically, CuSe/CoSe2 (CSC) exhibits TME-activated glutathione (GSH) depletion hydroxyl radical (•OH) generation potential ferroptosis. Meanwhile, remarkable photothermal conversion efficiency elevated photocatalytic ROS level both promote CSC heterostructures induce robust immunogenic cell death (ICD). Besides, loaded syrosingopine inhibitor achieves LA blockade cancer downregulating expression monocarboxylate transporter 4 (MCT4), which could sensitize ferroptosis intracellular milieu acidification neutralize acidic alleviate immunosuppression. Hence, advanced modulation confers potentiated infiltration ICD-stimulated T lymphocytes further reinforces antitumor therapy. In brief, CSC@Syro-mediated synergistic therapy elicit potent immunogenicity suppress proliferation metastasis effectually integrating regulation immunotherapy.

Язык: Английский

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Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 7326 - 7378

Опубликована: Март 13, 2023

Cancer thermal therapy, also known as hyperthermia has long been exploited to eradicate mass lesions that are now defined cancer. With the development of corresponding technologies and equipment, local therapies such radiofrequency ablation, microwave high-intensity focused ultrasound, have validated effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages adjacent normal tissues incomplete ablation particularly for large tumors, restricting their wide usage. Attributed versatile physiochemical properties, biomaterials specially designed potentiate treatments according unique working principles. Meanwhile, biomaterial-based delivery systems able bridge with other types treatment strategies chemotherapy, radiotherapy immunotherapy. Therefore, this review, we discuss recent progress functional reinforce by functioning sensitizers endow more efficient tumor-localized and/or vehicles synergize therapeutic modalities combined cancer treatments. Thereafter, provide a critical perspective on further biomaterial-assisted toward applications.

Язык: Английский

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Recent Advances in Near‐Infrared‐II Fluorescence Imaging for Deep‐Tissue Molecular Analysis and Cancer Diagnosis

Small, Год журнала: 2022, Номер 18(31)

Опубликована: Июнь 28, 2022

Abstract Fluorescence imaging with high sensitivity and minimal invasiveness has received tremendous attention, which can accomplish visualized monitoring evaluation of cancer progression. Compared the conventional first near‐infrared (NIR‐I) optical window (650–950 nm), fluorescence in second NIR (NIR‐II, 950–1700 nm) exhibits deeper tissue penetration capability higher temporal‐spatial resolution lower background interference for achieving deep‐tissue vivo real‐time development. Encouraged by significant preponderances, a variety multifunctional NIR‐II fluorophores have been designed fabricated sensitively biomarkers visualizing treatment procedure cancers. In this review, differences between NIR‐I are briefly introduced, especially advantages visualization tumors diagnosis. An important focus is to summarize biomarker analysis tumor visualization, brief introduction imaging‐guided therapy also presented. Finally, challenges reasonable prospects diagnosis clinical applications outlined.

Язык: Английский

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Orchestrated Yolk–Shell Nanohybrids Regulate Macrophage Polarization and Dendritic Cell Maturation for Oncotherapy with Augmented Antitumor Immunity

Advanced Materials, Год журнала: 2022, Номер 34(9)

Опубликована: Янв. 12, 2022

The protumoral and immunosuppressive tumor microenvironments greatly limit the antitumor immune responses of nanoparticles for cancer immunotherapy. Here, intrinsic immunomodulatory effects orchestrated their ability to simultaneously trigger antigen release, thereby reversing immunosuppression achieving potent immunity augmented therapy, are explored. By optimizing both composition morphology, a facile strategy is proposed construct yolk-shell nanohybrids (Fe3 O4 @C/MnO2 -PGEA, FCMP). FCMP utilized reprogram macrophages M1 phenotype induce maturation dendritic cells. In addition, chemical, magnetic, optical properties contribute amplified immunogenic cell death induced by multiaugmented chemodynamic therapy (CDT) synergistic treatment. Taking advantage unique structure, accurate T1 -T2 dual-mode magnetic resonance imaging can be realized CDT maximized through sufficient exposure Fe3 core MnO2 shell. Potent found substantially inhibit growth primary distant tumors. Furthermore, extended synthesis other with tailored properties. This work establishes novel fabrication multifunctional nanoplatforms structure effective immunomodulation-enhanced immunity.

Язык: Английский

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Dual‐Cascade Activatable Nanopotentiators Reshaping Adenosine Metabolism for Sono‐Chemodynamic‐Immunotherapy of Deep Tumors

Advanced Science, Год журнала: 2023, Номер 10(10)

Опубликована: Фев. 2, 2023

Immunotherapy is an attractive treatment strategy for cancer, while its efficiency and safety need to be improved. A dual-cascade activatable nanopotentiator sonodynamic therapy (SDT) chemodynamic (CDT)-cooperated immunotherapy of deep tumors via reshaping adenosine metabolism herein reported. This (NPMCA) constructed through crosslinking deaminase (ADA) with chlorin e6 (Ce6)-conjugated manganese dioxide (MnO2) nanoparticles a reactive oxygen species (ROS)-cleavable linker. In the tumor microenvironment ultrasound (US) irradiation, NPMCA mediates CDT SDT concurrently in covered 2-cm tissues produce abundant ROS, which results scissoring ROS-cleavable linkers activate ADA within NCMCA block metabolism. Moreover, immunogenic cell death (ICD) dying cells upregulation stimulator interferon genes (STING) triggered by generated ROS Mn2+ from NPMCA, respectively, leading activation antitumor immune response. The potency response further reinforced reducing accumulation activated ADA. As result, enables SDT-cooperated immunotherapy, showing obviously improved therapeutic efficacy inhibit growths bilateral tumors, primary are tissues.

Язык: Английский

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Synchronously Manipulating Absorption and Extinction Coefficient of Semiconducting Polymers via Precise Dual‐Acceptor Engineering for NIR‐II Excited Photothermal Theranostics

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(20)

Опубликована: Март 17, 2023

Integrating the ultralong excitation wavelength, high extinction coefficient, and prominent photothermal conversion ability into a single agent is an appealing yet significantly challenging task. Herein, precise dual-acceptor engineering strategy exploited for this attempt based on donor-acceptor (D-A) type semiconductor polymers by subtly regulating molar proportions of two employed electron acceptor moieties featuring different electronic affinity π-conjugation degrees, making full use active intramolecular motion-induced effect. The optimal polymer SP4 synchronously shows desirable second near-infrared (NIR-II) absorption, extremely satisfactory behavior. Consequently, unprecedented performance NPs 1064 nm laser-excited photoacoustic imaging (PAI)-guided therapy (PTT) demonstrated tumor diagnosis complete elimination.

Язык: Английский

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Leveraging Semiconducting Polymer Nanoparticles for Combination Cancer Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 36(1)

Опубликована: Окт. 21, 2023

Abstract Cancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced patients. However, immune‐related adverse events caused by also bring heavy burden Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic sonodynamic therapy. In addition, SPNs work functional nanocarrier synergize variety of immunomodulators amplify anti‐tumor immune responses. this review, SPNs‐based combination is comprehensively summarized according the SPNs’ modalities type loaded immunomodulators. The in‐depth understanding existing will hopefully inspire design more novel nanomaterials potent effects, ultimately promote their clinical translation.

Язык: Английский

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A Vacancy‐Engineering Ferroelectric Nanomedicine for Cuproptosis/Apoptosis Co‐Activated Immunotherapy

Advanced Materials, Год журнала: 2024, Номер 36(30)

Опубликована: Май 4, 2024

Abstract Low efficacy of immunotherapy due to the poor immunogenicity most tumors and their insufficient infiltration by immune cells highlights importance inducing immunogenic cell death activating system for achieving better treatment outcomes. Herein, ferroelectric Bi 2 CuO 4 nanoparticles with rich copper vacancies (named BCO‐V Cu ) are rationally designed engineered ferroelectricity‐enhanced apoptosis, cuproptosis, subsequently evoked immunotherapy. In this structure, suppressed recombination electron–hole pairs band bending polarization lead high catalytic activity, triggering reactive oxygen species bursts apoptosis. The fragments produced apoptosis serve as antigens activate T cells. Moreover, generated charge catalysis, nanomedicine can act “a smart switch” open membrane, promote nanomaterial endocytosis, shut down + outflow pathway evoke thus a strong response is triggered reduced content adenosine triphosphate. Ribonucleic acid transcription tests reveal pathways related activation. Thus, study firstly demonstrates feasible strategy enhancing using single semiconductor‐induced cuproptosis.

Язык: Английский

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