Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
61(8)
Опубликована: Дек. 20, 2021
Protease
inhibitors
can
modulate
intratumoral
metabolic
processes
to
reprogram
the
immunosuppressive
tumor
microenvironment
(TME),
which
however
suffer
from
limited
efficacy
and
off-targeted
side
effects.
We
report
smart
nano-proteolysis
targeting
chimeras
(nano-PROTACs)
with
phototherapeutic
ablation
cancer-specific
protein
degradation
TME
for
photo-metabolic
cancer
immunotherapy.
This
nano-PROTAC
has
a
semiconducting
polymer
backbone
linked
cyclooxygenase
1/2
(COX-1/2)-targeting
PROTAC
peptide
(CPP)
via
cathepsin
B
(CatB)-cleavable
segment.
CPP
be
activated
by
tumor-overexpressed
CatB
induce
of
COX-1/2
ubiquitin-proteasome
system.
The
persistent
depletes
their
metabolite
prostaglandin
E2
is
responsible
activation
immune
suppressor
cells.
Such
strategy
synergized
phototherapy
specifically
reprograms
reinvigorates
antitumor
immunity.
Abstract
Although
immunotherapy
has
revolutionized
cancer
therapy
by
providing
efficient
tumor
growth
suppression,
long‐term
protection
from
recurrence
as
well
minimized
side
effects,
the
low
response
rate
significantly
limits
clinical
application
of
in
board
types
solid
tumors.
In
order
to
improve
therapeutic
efficacy,
conventional
therapies
including
radiotherapy,
chemotherapy,
phototherapy
and
chemodynamic
are
employed
combine
with
elicit
stronger
antitumor
immune
responses.
Polymer
nanomedicines
frequently
utilized
synergistic
other
owing
their
tunable
physiochemical
properties,
high
drug
loading
capacity,
ease
modification
toxicity.
With
elaborate
design
tailored
polymer
can
enhance
efficacy
enhancing
specificity,
priming
cells
amplifying
responses
However,
until
now,
there
is
no
review
solely
dedicated
comprehensive
development
polymer‐based
platforms
for
combinational
cancers.
Herein,
this
paper
summarizes
latest
advances
design,
fabrication
traditional
strategies
photothermal
therapy,
photodynamic
therapies.
An
outlook
on
trajectory
potential
challenges
bridging
gap
between
also
discussed.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(16)
Опубликована: Янв. 4, 2024
Abstract
Second
near‐infrared
(NIR‐II)
bioimaging
technology
shows
broad
application
prospects
in
the
field
of
biomedical
due
to
its
significant
superiority
deep
tissue
penetration
and
high
signal‐to‐background
ratio.
Among
them,
organic
small
molecule
fluorophores
have
received
progressively
more
consideration
their
low
biotoxicity,
biocompatibility,
rapid
clearance,
good
modification
properties.
As
key
acceptor
core,
2,
1,
3‐benzothiadiazole
(BTD)
derivative
plays
an
essential
role
construction
donor‐acceptor‐donor
type
NIR‐II
fluorophores.
This
mini‐review
summarizes
research
development
based
on
BTD
derivatives
bioimaging,
focusing
molecular
design
photophysical
properties,
introduces
a
part
applications
biological
field.
Furthermore,
challenges
BTD‐based
future
are
discussed
.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Май 20, 2024
Abstract
Mild
photothermal
therapy
(PTT)
is
an
emerging
and
elegant
approach
with
minimal
adverse
effects,
demonstrating
itself
as
effective
treatment
for
cancer.
However,
potential
challenges
may
arise
from
the
overexpression
of
heat
shock
protein
90
(HSP90)
reliance
on
monotherapy.
Here,
a
near‐infrared
(NIR)
light‐triggered
MXene
nanocomposite
(FA@MXene/CuO
2
/GA)
developed
to
synergistically
combine
mild
PTT
chemodynamic
(CDT)
remarkably
tumor
eradication
without
any
notable
tissue
damage.
Under
irradiation
NIR
light,
effectively
enhances
by
suppressing
HSP90
expression
through
release
gambogic
acid
(GA)
due
excellent
performance
Ti
3
C
nanosheets
well
tumor‐targeting
ability
biocompatibility
surface‐modified
FA‐PEG‐SH.
The
copper‐based
catalyst
CuO
in
this
system
releases
Cu
2+
acid‐triggered
manner
within
microenvironment,
activating
Fenton‐like
reaction
generate
hydroxyl
radicals,
simultaneous
production
H
O
serves
alleviate
deficiency
endogenous
tumor.
Overall,
current
work
showcases
remarkable
synergistic
anticancer
effect
CDT,
also
proposes
new
avenues
research
utilizing
nanomaterials
treatment.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Photodynamic
therapy
(PDT)
and
photothermal
(PTT)
have
emerged
as
promising
treatment
options,
showcasing
immense
potential
in
addressing
both
oncologic
nononcologic
diseases.
Single‐component
organic
phototherapeutic
agents
(SCOPAs)
offer
advantages
compared
to
inorganic
or
multicomponent
nanomedicine,
including
better
biosafety,
lower
toxicity,
simpler
synthesis,
enhanced
reproducibility.
Nonetheless,
how
further
improve
the
therapeutic
effectiveness
of
SCOPAs
remains
a
challenging
research
area.
This
review
delves
deeply
into
strategies
performance
PDT
PTT
by
optimizing
structural
design
SCOPAs.
These
encompass
augmenting
reactive
oxygen
species
(ROS)
generation,
mitigating
dependence,
elevating
light
absorption
capacity,
broadening
region,
enhancing
conversion
efficiency
(PCE).
Additionally,
this
also
underscores
ideal
for
developing
with
balanced
PTT.
Furthermore,
synergies
are
highlighted
between
other
modalities
such
ferroptosis,
gas
therapy,
chemotherapy,
immunotherapy.
By
providing
comprehensive
analysis
these
strategies,
aspires
serve
valuable
resource
clinicians
researchers,
facilitating
wider
application
advancement
SCOPAs‐mediated
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
61(8)
Опубликована: Дек. 20, 2021
Protease
inhibitors
can
modulate
intratumoral
metabolic
processes
to
reprogram
the
immunosuppressive
tumor
microenvironment
(TME),
which
however
suffer
from
limited
efficacy
and
off-targeted
side
effects.
We
report
smart
nano-proteolysis
targeting
chimeras
(nano-PROTACs)
with
phototherapeutic
ablation
cancer-specific
protein
degradation
TME
for
photo-metabolic
cancer
immunotherapy.
This
nano-PROTAC
has
a
semiconducting
polymer
backbone
linked
cyclooxygenase
1/2
(COX-1/2)-targeting
PROTAC
peptide
(CPP)
via
cathepsin
B
(CatB)-cleavable
segment.
CPP
be
activated
by
tumor-overexpressed
CatB
induce
of
COX-1/2
ubiquitin-proteasome
system.
The
persistent
depletes
their
metabolite
prostaglandin
E2
is
responsible
activation
immune
suppressor
cells.
Such
strategy
synergized
phototherapy
specifically
reprograms
reinvigorates
antitumor
immunity.
