Recent applications of immunomodulatory biomaterials for disease immunotherapy

Exploration, Год журнала: 2022, Номер 2(6)

Опубликована: Май 23, 2022

Immunotherapy is used to regulate systemic hyperactivation or hypoactivation treat various diseases. Biomaterial-based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory of biomaterials themselves cannot be neglected. In this review, we outline with functions discovered in recent years and their applications disease treatment. These inflammation, tumors, autoimmune diseases by regulating immune cell function, exerting enzyme-like activity, neutralizing cytokines, The prospects challenges biomaterial-based modulation are also discussed.

Язык: Английский

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Remodeling Tumor‐Associated Neutrophils to Enhance Dendritic Cell‐Based HCC Neoantigen Nano‐Vaccine Efficiency

Advanced Science, Год журнала: 2022, Номер 9(11)

Опубликована: Фев. 10, 2022

Abstract Hepatocellular carcinoma (HCC) commonly emerges in an immunologically “cold” state, thereafter protects it away from cytolytic attack by tumor‐infiltrating lymphocytes, resulting poor response to immunotherapy. Herein, acidic/photo‐sensitive dendritic cell (DCs)‐based neoantigen nano‐vaccine has been explored convert tumor immune state into “hot”, and remodel tumor‐associated neutrophils potentiate anticancer for enhancing immunotherapy efficiency. The is constructed SiPCCl 2 ‐hybridized mesoporous silica with coordination of Fe(III)‐captopril, coating exfoliated membrane matured DCs H22‐specific stimulation. nano‐vaccines actively target H22 tumors induce immunological death boost antigen release the generation excess 1 O through photodynamic therapy, which act as situ vaccination strengthen antitumor T‐cell against primary growth. Interestingly, are also home lymph nodes directly activation proliferation neoantigen‐specific T cells suppress primary/distal Moreover, acidic‐triggered captopril microenvironment can polarize protumoral N2 phenotype N1 improving effects achieve complete regression (83%) H22‐bearing mice prolong survival time. This work provides alternative approach developing novel HCC strategies.

Язык: Английский

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Progress of engineered bacteria for tumor therapy

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 185, С. 114296 - 114296

Опубликована: Апрель 16, 2022

Язык: Английский

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Promising dawn in tumor microenvironment therapy: engineering oral bacteria

International Journal of Oral Science, Год журнала: 2024, Номер 16(1)

Опубликована: Март 13, 2024

Abstract Despite decades of research, cancer continues to be a major global health concern. The human mouth appears multiplicity local environments communicating with other organs and causing diseases via microbes. Nowadays, the role oral microbes in development progression has received increasing scrutiny. At same time, bioengineering technology nanotechnology is growing rapidly, which physiological activities natural bacteria are modified improve therapeutic efficiency cancers. These engineered were transformed achieve directed genetic reprogramming, selective functional reorganization precise control. In contrast endotoxins produced by typical genetically bacteria, flora exhibits favorable biosafety characteristics. To outline current cognitions upon microbes, cancers, related literatures searched reviewed based on PubMed database. We focused number mechanisms associated tumor microenvironment, involve occurrence development. Whether engineering can possible application therapy worth consideration. A deeper understanding relationship between may enhance our knowledge pathogenesis thus providing new insights strategies for prevention treatment.

Язык: Английский

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Augmenting Immunotherapy via Bioinspired MOF‐Based ROS Homeostasis Disruptor with Nanozyme‐Cascade Reaction

Advanced Materials, Год журнала: 2023, Номер 35(49)

Опубликована: Сен. 10, 2023

Despite its remarkable clinical breakthroughs, immune checkpoint blockade (ICB) therapy remains limited by the insufficient response in "cold" tumor. Nanozyme-based antitumor catalysis is associated with precise activation tumor microenvironment (TME). In this study, a cascade-augmented nanoimmunomodulator (CMZM) multienzyme-like activities, which includes superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and glutathione oxidase (GSHOx), that dissociates under an acidic abundant GSH TME, proposed for multimodal imaging-guided chemodynamic (CDT)/photodynamic (PDT) enhanced immunotherapy. Vigorous activities can not only produce O2 to alleviate hypoxia promote polarization of M2 M1 macrophages, but also generate ROS (•OH 1 ) deplete TME expose necrotic cell fragments reverse immunosuppressive eliciting maturation dendritic cells infiltration cytotoxic T lymphocytes (CTLs) tumors. Therefore, inhibitory effects on both primary distant tumors are achieved through synergy α-PD-L1 blocking antibody. This cascade multienzyme-based nanoplatform provides smart strategy highly efficient ICB immunotherapy against revising TME.

Язык: Английский

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Responsive biomaterials: optimizing control of cancer immunotherapy

Nature Reviews Materials, Год журнала: 2023, Номер 9(2), С. 100 - 118

Опубликована: Дек. 22, 2023

Язык: Английский

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Metformin-based nanomedicines for reprogramming tumor immune microenvironment

Theranostics, Год журнала: 2024, Номер 15(3), С. 993 - 1016

Опубликована: Дек. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Язык: Английский

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Biomimetic design strategies for biomedical applications

Matter, Год журнала: 2024, Номер 7(3), С. 826 - 854

Опубликована: Янв. 22, 2024

Язык: Английский

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P-glycoprotein (P-gp)-driven cancer drug resistance: biological profile, non-coding RNAs, drugs and nanomodulators

Drug Discovery Today, Год журнала: 2024, Номер 29(11), С. 104161 - 104161

Опубликована: Сен. 7, 2024

Язык: Английский

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Tumor-Microenvironment-Activatable Nanoparticle Mediating Immunogene Therapy and M2 Macrophage-Targeted Inhibitor for Synergistic Cancer Immunotherapy

ACS Nano, Год журнала: 2024, Номер 18(4), С. 3295 - 3312

Опубликована: Янв. 22, 2024

Immunotherapy has achieved prominent clinical efficacy in combating cancer and recently become a mainstream treatment strategy. However, achieving broad with single modality is challenging, the heterogeneity of tumor microenvironment (TME) restricts accuracy effectiveness immunotherapy strategies for tumors. Herein, TME-responsive targeted nanoparticle to enhance antitumor immunity reverse immune escape by codelivering interleukin-12 (IL-12) expressing gene colony-stimulating factor-1 receptor (CSF-1R) inhibitor PLX3397 (PLX) presented. The introduction disulfide bonds cyclo(Arg-Gly-Asp-d-Phe-Lys) (cRGD) peptides conferred reduction reactivity targeting nanoparticles, respectively. It hypothesized that activating host local expression IL-12, while modulating tumor-associated macrophages (TAM) function through blocking CSF-1/CSF-1R signaling, could constitute feasible approach immunotherapy. fabricated functional successfully ameliorated TME stimulating proliferation activation T lymphocytes, promoting repolarization TAMs, reducing myeloid-derived suppressor cells (MDSCs), maturation dendritic (DC) as well secretion cytokines, which efficiently suppressed growth metastasis. Finally, substantial changes were deciphered single-cell analysis including infiltration different cells, transcriptional states, secretory signaling cell–cell communications. These findings provide promising combinatorial strategy immunomodulatory nanoparticles.

Язык: Английский

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