Recent applications of immunomodulatory biomaterials for disease immunotherapy

Exploration, Год журнала: 2022, Номер 2(6)

Опубликована: Май 23, 2022

Immunotherapy is used to regulate systemic hyperactivation or hypoactivation treat various diseases. Biomaterial-based immunotherapy systems can improve therapeutic effects through targeted drug delivery, immunoengineering, etc. However, the immunomodulatory of biomaterials themselves cannot be neglected. In this review, we outline with functions discovered in recent years and their applications disease treatment. These inflammation, tumors, autoimmune diseases by regulating immune cell function, exerting enzyme-like activity, neutralizing cytokines, The prospects challenges biomaterial-based modulation are also discussed.

Язык: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Ноя. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Язык: Английский

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Reactive oxygen species-powered cancer immunotherapy: Current status and challenges

Journal of Controlled Release, Год журнала: 2023, Номер 356, С. 623 - 648

Опубликована: Март 21, 2023

Язык: Английский

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Tumor Microenvironment‐Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 36(6)

Опубликована: Сен. 19, 2023

Abstract Insufficient activation of the stimulator interferon genes (STING) signaling pathway and profoundly immunosuppressive microenvironment largely limits effect cancer immunotherapy. Herein, tumor (TME)‐responsive nanoparticles (PMM NPs) are exploited that simultaneously harness STING Toll‐like receptor 4 (TLR4) to augment via TLR4‐mediated nuclear factor‐kappa B stimulation, leading increased secretion type I interferons (i.e., 4.0‐fold enhancement IFN‐β) pro‐inflammatory cytokines promote a specific T cell immune response. Moreover, PMM NPs relieve immunosuppression TME by decreasing percentage regulatory cells, polarizing M2 macrophages M1 type, thus creating an immune‐supportive unleash cascade adaptive Combined with anti‐PD‐1 antibody, synergistic efficacy is achieved in both inflamed colorectal noninflamed metastatic breast models. rechallenging tumor‐free animals homotypic cells induced complete rejection, indicating generation systemic antitumor memory. These TME‐responsive may open new avenue achieve spatiotemporal orchestration activation, providing promising clinical candidate for next‐generation

Язык: Английский

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Glutathione‐Scavenging Celastrol‐Cu Nanoparticles Induce Self‐Amplified Cuproptosis for Augmented Cancer Immunotherapy

Advanced Materials, Год журнала: 2024, Номер 36(35)

Опубликована: Июнь 27, 2024

Cuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis highly dependent on intracellular copper accumulation and counteracted by high level glutathione (GSH) in tumor cells. Here, this work develops self-amplified nanoparticles (Cel-Cu NP) using celastrol (Cel), natural product isolated from medical plant. In Cel-Cu NP, Cel serves as versatile ionophore, exhibiting an ideal coordination capacity toward ions without compromising the induction. Notably, can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, further activates immunogenic death (ICD) elicit robust immune response. Combining with checkpoint blockade, NP effectively eradicates metastatic tumors mouse lung metastasis model. This study provides efficient nanomedicine inducing for immunotherapy.

Язык: Английский

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Multifunctional Calcium–Manganese Nanomodulator Provides Antitumor Treatment and Improved Immunotherapy via Reprogramming of the Tumor Microenvironment

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15449 - 15465

Опубликована: Авг. 2, 2023

Ions play a vital role in regulating various biological processes, including metabolic and immune homeostasis, which involves tumorigenesis therapy. Thus, the perturbation of ion homeostasis can induce tumor cell death evoke responses, providing specific antitumor effects. However, strategies that exploit effects multiion are rare. We herein prepared pH-responsive nanomodulator by coloading curcumin (CU, Ca

Язык: Английский

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Extracellular Matrix Viscosity Reprogramming by In Situ Au Bioreactor-Boosted Microwavegenetics Disables Tumor Escape in CAR-T Immunotherapy

ACS Nano, Год журнала: 2023, Номер 17(6), С. 5503 - 5516

Опубликована: Март 14, 2023

Incomplete microwave ablation (iMWA) caused by uncontrollable heat diffusion enhances the immunosuppressive tumor microenvironment (ITM), consequently disabling prevalent immune checkpoint blockade-combined immunotherapy against recurrence. Herein, we successfully constructed an intratumorally synthesized Au bioreactor to disperse in thermally sensitive hydrogel-filled tumors and improve energy utilization efficiency, which magnified effective zone (EAZ), counteracted iMWA, simultaneously established enhanced multiple biological process-regulated microwavegenetics. More significantly, identified extracellular matrix (ECM) viscosity as a general escape "target". After remodeling ECM, including ECM ingredients cell adhesion molecules, this physical target was blocked reprogramming, furnishing tool regulate target. Thereby, such situ bioreactor-enlarged EAZ microwavegenetics reversed immune-desert microenvironment, mitigated ITM, secreted cell-attracting chemokines, recruited polarized various cells, activated or reactivated them like dendritic natural killing M1-type macrophages, effector CD8+ CAR-T cells. Contributed these actions, oncolytic bioreactors evoked acquire considerably increased inhibition effect progression recurrence after thus providing method enhance iMWA immunotherapy.

Язык: Английский

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Exosome regulation of immune response mechanism: Pros and cons in immunotherapy

Bioactive Materials, Год журнала: 2023, Номер 32, С. 124 - 146

Опубликована: Окт. 4, 2023

Due to its multiple features, including the ability orchestrate remote communication between different tissues, exosomes are extracellular vesicles arousing highest interest in scientific community. Their size, established as an average of 30-150 nm, allows them be easily uptaken by most cells. According type cells-derived exosomes, they may carry specific biomolecular cargoes used reprogram cells interacting with. In certain circumstances, stimulate immune response facilitating or amplifying release foreign antigens-killing cells, inflammatory factors, antibodies (immune activation). Meanwhile, other cases, efficiently malignant elements such cancer mislead recognition mechanism, carrying and transferring their cancerous distant healthy thus contributing antigenic invasion suppression). Exosome dichotomic patterns upon system regulation present broad advantages immunotherapy. Its perfect comprehension, from early biogenesis interaction with recipient will promote a significant enhancement immunotherapy employing molecular biology, nanomedicine, nanotechnology.

Язык: Английский

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Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy

Advanced Science, Год журнала: 2024, Номер 11(13)

Опубликована: Янв. 25, 2024

Abstract Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy cuproptosis remains limited by poor delivery efficiency copper ion carriers. Herein, complex nanoparticles (denoted as Cu(I) NP) are developed that can efficiently deliver into cells to induce cuproptosis. NP demonstrate stimulus‐responsive release complexes, which results mitochondrial dysfunction and promotes aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), leading Notably, not only cuproptosis, but also elicit robust immune responses suppress tumor growth. Overall, this study provides a promising strategy for cuproptosis‐based

Язык: Английский

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Decomposable Nanoagonists Enable NIR‐Elicited cGAS‐STING Activation for Tandem‐Amplified Photodynamic‐Metalloimmunotherapy

Advanced Materials, Год журнала: 2024, Номер 36(21)

Опубликована: Фев. 14, 2024

Activation of the cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway has emerged as an efficient strategy to improve therapeutic outcomes immunotherapy. However, "constantly active" mode current STING agonist delivery strategies typically leads off-target toxicity and hyperimmunity. To address this critical issue, herein a metal-organic frameworks-based nanoagonist (DZ@A7) featuring tumor-specific near-infrared (NIR) light-enhanced decomposition is constructed for precisely localized activation photodynamic-metalloimmunotherapy. The engineered enabled generation mitochondria-targeted reactive oxygen species under NIR irradiation specifically release mitochondrial DNA (mtDNA) inhibit repair nuclear via hypoxia-responsive drugs. Oxidized tumor mtDNA serves endogenous danger-associated molecular pattern that activates cGAS-STING pathway. Concurrently, NIR-accelerated zinc ions overloading in cancer cells further enhance cGAS enzymatic activity through metalloimmune effects. By combining synergistically enhanced triggered by irradiation, facilitated maturation dendritic infiltration cytotoxic T lymphocytes primary eradication, which also established long-term anti-tumor immunity suppress metastasis. Therefore, developed NIR-triggered, agonist-free, tandem-amplified pathway, thereby offering distinct paradigm

Язык: Английский

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