Near-Infrared-Absorbing B–N Lewis Pair-Functionalized Anthracenes: Electronic Structure Tuning, Conformational Isomerism, and Applications in Photothermal Cancer Therapy

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(41), С. 18908 - 18917

Опубликована: Окт. 4, 2022

B–N-fused dianthracenylpyrazine derivatives are synthesized to generate new low gap chromophores. Photophysical and electrochemical, crystal packing, theoretical studies have been performed. Two energetically similar conformers identified by density functional theory calculations, showing that the core unit adopts a curved saddle-like shape (x-isomer) or zig-zag conformation (z-isomer). In solid state, z-isomer is prevalent according an X-ray structure of C6F5-substituted derivative (4-Pf), but variable-temperature nuclear magnetic resonance suggest dynamic behavior in solution. B–N fusion results large decrease HOMO–LUMO dramatically lowers LUMO energy compared all-carbon analogues. 4-Pf particular shows significant absorbance at greater than 700 nm while being almost transparent throughout visible region. After encapsulation biodegradable polymer DSPE-mPEG2000, nanoparticles (4-Pf-NPs) exhibit good water solubility, high photostability, excellent photothermal conversion efficiency ∼41.8%. 4-Pf-NPs evaluated both vitro vivo as therapeutic agents. These uncover Lewis pair functionalization PAHs promising strategy toward NIR-absorbing materials for applications.

Язык: Английский

---

Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(32), С. 14420 - 14440

Опубликована: Авг. 4, 2022

There has been emerging interest in the exploitation of photophysical and photochemical properties transition metal complexes for diagnostic therapeutic applications. In this Perspective, we highlight major recent advances development luminescent photofunctional complexes, particular, those rhenium(I), ruthenium(II), osmium(II), iridium(III), platinum(II), as bioimaging reagents phototherapeutic agents, with a focus on molecular design strategies that harness modulate interesting behavior complexes. We also discuss current challenges future outlook both fundamental research clinical

Язык: Английский

---

Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

Chemical Society Reviews, Год журнала: 2023, Номер 52(16), С. 5607 - 5651

Опубликована: Янв. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Язык: Английский

---

MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Ноя. 4, 2021

Abstract Targeting subcellular organelle with multilevel damage has shown great promise for antitumor therapy. Here, we report a core-shell type of nanoagent iron (III) carboxylate metal-organic frameworks (MOFs) as shell while upconversion nanoparticles (UCNPs) core, which enables near-infrared (NIR) light-triggered synergistically reinforced oxidative stress and calcium overload to mitochondria. The folate decoration on MOFs shells efficient cellular uptake nanoagents. Based the ability UCNPs, NIR light mediates Fe 3+ -to-Fe 2+ reduction simultaneously activates photoacid generator (pHP) encapsulated in cavities, release free acidification intracellular microenvironment, respectively. overexpressed H 2 O mitochondria, highly reactive acidic milieu reinforce Fenton reactions producing lethal hydroxyl radicals (•OH) plasma photoacidification inducing influx, leading mitochondria overload. dual-mitochondria-damage-based therapeutic potency been unequivocally confirmed cell- patient-derived tumor xenograft models vivo.

Язык: Английский

---

A Bacteria‐Responsive Porphyrin for Adaptable Photodynamic/Photothermal Therapy

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(23)

Опубликована: Март 25, 2022

Abstract We report a cationic porphyrin 5,10,15,20‐tetrakis‐(4‐ N ‐methylpyridyl)‐porphyrin (TMPyP) that can respond to specific bacteria, followed by adaptable photodynamic/photothermal therapy processes. TMPyP could be reduced phlorin facultative anaerobes with strong reducing ability such as E. coli and S. typhimurium in hypoxic environments, possessing NIR absorption remarkable photothermal conversion capacity, thus demonstrating excellent antimicrobial activity (>99 %) therapy. While an aerobic environment functioned typical photosensitizer killed bacteria effectively (>99.9 photodynamic By forming host–guest complex cucurbit[7]uril, the biocompatibility of significantly improved. This kind bacteria‐responsive shows specificity adaptivity treatment holds potential non‐invasive treatments bacterial infections.

Язык: Английский

---

Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy

Biomaterials, Год журнала: 2022, Номер 281, С. 121369 - 121369

Опубликована: Янв. 7, 2022

Язык: Английский

---

Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Год журнала: 2022, Номер 476, С. 214908 - 214908

Опубликована: Ноя. 7, 2022

Язык: Английский

---

Near-infrared metal agents assisting precision medicine: from strategic design to bioimaging and therapeutic applications

Chemical Society Reviews, Год журнала: 2023, Номер 52(13), С. 4392 - 4442

Опубликована: Янв. 1, 2023

Metal agents have made incredible strides in preclinical research and clinical applications, but their short emission/absorption wavelengths continue to be a barrier distribution, therapeutic action, visual tracking, efficacy evaluation.

Язык: Английский

---

Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(24)

Опубликована: Апрель 26, 2023

Photodynamic therapy (PDT), with its advantages of high targeting, minimally invasive, and low toxicity side effects, has been widely used in the clinical various tumors, especially superficial tumors. However, tumor microenvironment (TME) presents hypoxia due to oxygen (O2 ) supply caused by abnormal vascularization neoplastic tissues O2 consumption induced rapid proliferation cells. The efficacy oxygen-consumping PDT can be hampered a hypoxic TME. To address this problem, researchers have developing advanced nanoplatforms strategies enhance therapeutic effect treatment. This review summarizes recent against TME, thus enhancing efficacy, including increasing content TME through delivering tumors situ generations ; decreasing during design type I photosensitizers. Moreover, synergistically combined other methods such as chemotherapy, photothermal therapy, immunotherapy, gas is accounted for addressing challenging problems mono environments, resistance, proliferation, metastasis. Finally, perspectives opportunities challenges future research translations are provided.

Язык: Английский

---

Nanoarchitecture-Integrated Hydrogel Systems toward Therapeutic Applications

ACS Nano, Год журнала: 2023, Номер 17(9), С. 7953 - 7978

Опубликована: Апрель 18, 2023

Hydrogels, as one of the most feasible soft biomaterials, have gained considerable attention in therapeutic applications by virtue their tunable properties including superior patient compliance, good biocompatibility and biodegradation, high cargo-loading efficiency. However, hydrogel application is still limited some challenges like inefficient encapsulation, easy leakage loaded cargoes, lack controllability. Recently, nanoarchitecture-integrated systems were found to be therapeutics with optimized properties, extending bioapplication. In this review, we briefly presented category hydrogels according synthetic materials further discussed advantages Additionally, various nanoarchitecture hybrid biomedical engineering are systematically summarized, cancer therapy, wound healing, cardiac repair, bone regeneration, diabetes obesity therapy. Last, current challenges, limitations, future perspectives development flexible addressed.

Язык: Английский

---