Theranostic Fluorescent Probes

Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2699 - 2804

Опубликована: Фев. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Язык: Английский

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Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(43)

Опубликована: Сен. 5, 2023

Despite metal-based photosensitizers showing great potential in photodynamic therapy for tumor treatment, the application of is intrinsically limited by their poor cancer-targeting properties. Herein, we reported a photosensitizer-bacteria hybrid, Ir-HEcN, via covalent labeling an iridium(III) photosensitizer to surface genetically engineered bacteria. Due its intrinsic self-propelled motility and hypoxia tropism, Ir-HEcN selectively targets penetrates deeply into tissues. Importantly, capable inducing pyroptosis immunogenic cell death cells under irradiation, thereby remarkably evoking anti-tumor innate adaptive immune responses vivo leading regression solid tumors combinational immunotherapy. To best our knowledge, first metal complex decorated bacteria enhanced

Язык: Английский

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Reduction of Platinum(IV) Prodrug Hemoglobin Nanoparticles with Deeply Penetrating Ultrasound Radiation for Tumor‐Targeted Therapeutically Enhanced Anticancer Therapy

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(22)

Опубликована: Март 24, 2023

The development of PtIV prodrugs that are reduced into the therapeutically active PtII species within tumor microenvironment has received much research interest. In order to provide spatial and temporal control over treatment, there is a high demand for compounds could be selectively activated upon irradiation. Despite recent progress, majority complexes excited with ultraviolet or blue light, limiting use such superficial application. To overcome this limitation, herein, first example prodrug nanoparticles deeply penetrating ultrasound radiation reported, enabling treatment deep-seated large tumors. were found accumulate inside mouse colon carcinoma intravenous injection able eradicate exposure radiation.

Язык: Английский

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Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Chemical Reviews, Год журнала: 2024, Номер 124(15), С. 8825 - 9014

Опубликована: Июль 25, 2024

Luminescence imaging is a powerful and versatile technique for investigating cell physiology pathology in living systems, making significant contributions to life science research clinical diagnosis. In recent years, luminescent transition metal complexes have gained attention diagnostic therapeutic applications due their unique photophysical photochemical properties. this Review, we provide comprehensive overview of the development bioimaging biosensing applications, with focus on centers d

Язык: Английский

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Multimetallic transition metal complexes:Luminescent probes for biomolecule sensing, ion detection, imaging and therapeutic application

Coordination Chemistry Reviews, Год журнала: 2024, Номер 504, С. 215656 - 215656

Опубликована: Янв. 19, 2024

Язык: Английский

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Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemoresistant Cancer

Inorganic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT PTT) cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen superoxide anion, release heat when exposed to infrared (IR) irradiation, thus inducing reactive species (ROS)-associated cell disruption thermal ablation. The IR-generated ROS can further activate caspases, triggering apoptosis. Additionally, the deplete intracellular glutathione, lead lipid peroxidation, induce ferroptosis. selected complex

Язык: Английский

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Isomer Engineering of Lepidine-Based Iridophosphors for Far-Red Hypoxia Imaging and Photodynamic Therapy

Inorganic Chemistry, Год журнала: 2022, Номер 61(44), С. 17703 - 17712

Опубликована: Окт. 26, 2022

The development of highly efficient cyclometalated phosphorescent iridium(III) complexes is greatly promoted by their rational molecular design. Manipulating the excited states iridophosphors could endow them with appealing photophysical properties, which play vital roles in triplet state-related photofunctional applications (e.g., electroluminescence, photodynamic therapy, etc.). In general, most effective approach for decreasing emission energies to extend π-skeleton ligands. However, π-extension strategy often results decreased solubility, lower synthetic yield, photoluminescence quantum and so forth. this work, a simple yet proposed excited-state manipulation 2-phenyllepidine-based iridophosphors. Surprisingly, dramatic tuning phosphorescence wavelength (∼70 nm) achieved simply controlling position single methoxyl substituent on these An oxygen-responsive iridophosphor featuring far-red (660 nm), long lifetime (1.60 μs), high singlet oxygen yield (0.73) employed realize accurate sensing vitro vivo, it also shows therapy cancer cells, making promising candidate image-guided therapeutic agent. This design clearly demonstrates advantages designing novel long-wavelength emissive without increasing π-conjugation ligand.

Язык: Английский

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Design of Near-Infrared-Triggered Metallo-Photosensitizers via a Self-Assembly-Induced Vibronic Decoupling Strategy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(21), С. 11633 - 11642

Опубликована: Май 19, 2023

Development of highly efficient near-infrared (NIR)-excited photosensitizers is hampered by the fast nonradiative vibrational relaxation process regulated energy gap law. Here, from fundamental perspective we propose that intermolecular coupling well-designed has potential to facilitate exciton delocalization and hence reduce exciton-vibration coupling, thereby boosting their phototherapeutic efficacy via inhibition pathway. Such conceived NIR-excited metallo-photosensitizers (IrHA1 IrHA2) were prepared studied for experimental validation. The resulting iridium complexes exhibited a little singlet oxygen (1O2) production in monomeric state, but produced substantially enhanced 1O2 generation efficiency benefiting decoupling self-assembly state. Particularly, IrHA2 exhibits an unprecedented high quantum yield 54.9% (FDA-approved NIR dye indocyanine green: ΦΔ = 0.2%) under 808 nm laser irradiation with negligible heat generation, probably attributed suppression vibronic couplings stretching mode acceptor ligand. In phototherapy, IrHA2-NPs biocompatibility low dark toxicity can induce substantial tumor regression 92.9% volume reduction vivo. This self-assembly-induced strategy would offer effective approach design high-performance photosensitizers.

Язык: Английский

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One-Pot Synthesis of Acetylacetonate-Based Isomeric Phosphorescent Cyclometalated Iridium(III) Complexes via Random Cyclometalation: A Strategy for Excited-State Manipulation

Inorganic Chemistry, Год журнала: 2023, Номер 62(3), С. 1202 - 1209

Опубликована: Янв. 9, 2023

The excited-state manipulation of the phosphorescent iridium(III) complexes plays a vital role in their photofunctional applications. development molecular design strategy promotes creative findings novel complexes. current strategies for mainly depend on selective cyclometalation ligands with ion, which is governed by steric hindrance ligand during cyclometalation. Herein, new (i.e., random strategy) proposed effective cyclometalated Two series and separable methoxyl-functionalized isomeric are accessed one-pot synthesis via cyclometalation, resulting dramatic tuning phosphorescence peak wavelength (∼57 nm) electrochemical properties attributed to high sensitivity excited states position methoxyl group. These show intense ranging from yellow (567 deep-red (634 color photoluminescence quantum yields up 0.99. emissive short decay lifetimes further utilized as triplet emitters afford efficient solution-processed electroluminescence reduced efficiency roll-offs.

Язык: Английский

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Development and Application of Ruthenium(II) and Iridium(III) Based Complexes for Anion Sensing

Molecules, Год журнала: 2023, Номер 28(3), С. 1231 - 1231

Опубликована: Янв. 27, 2023

Improvements in the design of receptors for detection and quantification anions are desirable ongoing field anion chemistry, remarkable progress has been made this direction. In regard, development luminescent chemosensors sensing is an imperative demanding sub-area supramolecular chemistry. This decade, particular, witnessed advancements based on ruthenium iridium complexes by virtue their modular synthesis rich chemical photophysical properties, such as visible excitation wavelength, high quantum efficiency, luminescence intensity, long lifetimes phosphorescence, large Stokes shifts, etc. Thus, review aims to summarize recent advances ruthenium(II) iridium(III)-based application sensing. addition, focus was devoted designing aspects polypyridyl these two transition metals with different recognition motifs, which upon interacting inorganic anions, produces quantifiable outputs.

Язык: Английский

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