Inorganic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(5), С. 1434 - 1449
Опубликована: Янв. 1, 2024
Three
Ir(
iii
)
complex-based
AIEgens
have
been
developed
to
detect
picric
acid
efficiently
in
aqueous
solution.
The
bright
emission
of
these
complexes
the
aggregated
and
crystalline
states
is
supported
by
crystal
structure
triplet
state
TDDFT
study.
Chemical Reviews,
Год журнала:
2024,
Номер
124(5), С. 2699 - 2804
Опубликована: Фев. 29, 2024
The
ability
to
gain
spatiotemporal
information,
and
in
some
cases
achieve
control,
the
context
of
drug
delivery
makes
theranostic
fluorescent
probes
an
attractive
intensely
investigated
research
topic.
This
interest
is
reflected
steep
rise
publications
on
topic
that
have
appeared
over
past
decade.
Theranostic
probes,
their
various
incarnations,
generally
comprise
a
fluorophore
linked
masked
drug,
which
released
as
result
certain
stimuli,
with
both
intrinsic
extrinsic
stimuli
being
reported.
release
then
signaled
by
emergence
signal.
Importantly,
use
appropriate
fluorophores
has
enabled
not
only
this
emerging
fluorescence
marker
for
but
also
provided
modalities
useful
photodynamic,
photothermal,
sonodynamic
therapeutic
applications.
In
review
we
highlight
recent
work
particular
focus
are
activated
tumor
microenvironments.
We
summarize
efforts
develop
other
applications,
such
neurodegenerative
diseases
antibacterials.
celebrates
diversity
designs
reported
date,
from
discrete
small-molecule
systems
nanomaterials.
Our
aim
provide
insights
into
potential
clinical
impact
still-emerging
direction.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(43)
Опубликована: Сен. 5, 2023
Despite
metal-based
photosensitizers
showing
great
potential
in
photodynamic
therapy
for
tumor
treatment,
the
application
of
is
intrinsically
limited
by
their
poor
cancer-targeting
properties.
Herein,
we
reported
a
photosensitizer-bacteria
hybrid,
Ir-HEcN,
via
covalent
labeling
an
iridium(III)
photosensitizer
to
surface
genetically
engineered
bacteria.
Due
its
intrinsic
self-propelled
motility
and
hypoxia
tropism,
Ir-HEcN
selectively
targets
penetrates
deeply
into
tissues.
Importantly,
capable
inducing
pyroptosis
immunogenic
cell
death
cells
under
irradiation,
thereby
remarkably
evoking
anti-tumor
innate
adaptive
immune
responses
vivo
leading
regression
solid
tumors
combinational
immunotherapy.
To
best
our
knowledge,
first
metal
complex
decorated
bacteria
enhanced
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(22)
Опубликована: Март 24, 2023
The
development
of
PtIV
prodrugs
that
are
reduced
into
the
therapeutically
active
PtII
species
within
tumor
microenvironment
has
received
much
research
interest.
In
order
to
provide
spatial
and
temporal
control
over
treatment,
there
is
a
high
demand
for
compounds
could
be
selectively
activated
upon
irradiation.
Despite
recent
progress,
majority
complexes
excited
with
ultraviolet
or
blue
light,
limiting
use
such
superficial
application.
To
overcome
this
limitation,
herein,
first
example
prodrug
nanoparticles
deeply
penetrating
ultrasound
radiation
reported,
enabling
treatment
deep-seated
large
tumors.
were
found
accumulate
inside
mouse
colon
carcinoma
intravenous
injection
able
eradicate
exposure
radiation.
Chemical Reviews,
Год журнала:
2024,
Номер
124(15), С. 8825 - 9014
Опубликована: Июль 25, 2024
Luminescence
imaging
is
a
powerful
and
versatile
technique
for
investigating
cell
physiology
pathology
in
living
systems,
making
significant
contributions
to
life
science
research
clinical
diagnosis.
In
recent
years,
luminescent
transition
metal
complexes
have
gained
attention
diagnostic
therapeutic
applications
due
their
unique
photophysical
photochemical
properties.
this
Review,
we
provide
comprehensive
overview
of
the
development
bioimaging
biosensing
applications,
with
focus
on
centers
d
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
A
series
of
dinuclear
Ir(III)
complexes
have
been
constructed
for
enhanced
photodynamic
and
photothermal
therapy
(PDT
PTT)
cisplatin-resistant
non-small-cell
lung
cancer.
They
enter
cells
via
caveolar
endocytosis,
target
mitochondria
but
not
nuclear,
generate
both
singlet
oxygen
superoxide
anion,
release
heat
when
exposed
to
infrared
(IR)
irradiation,
thus
inducing
reactive
species
(ROS)-associated
cell
disruption
thermal
ablation.
The
IR-generated
ROS
can
further
activate
caspases,
triggering
apoptosis.
Additionally,
the
deplete
intracellular
glutathione,
lead
lipid
peroxidation,
induce
ferroptosis.
selected
complex
Inorganic Chemistry,
Год журнала:
2022,
Номер
61(44), С. 17703 - 17712
Опубликована: Окт. 26, 2022
The
development
of
highly
efficient
cyclometalated
phosphorescent
iridium(III)
complexes
is
greatly
promoted
by
their
rational
molecular
design.
Manipulating
the
excited
states
iridophosphors
could
endow
them
with
appealing
photophysical
properties,
which
play
vital
roles
in
triplet
state-related
photofunctional
applications
(e.g.,
electroluminescence,
photodynamic
therapy,
etc.).
In
general,
most
effective
approach
for
decreasing
emission
energies
to
extend
π-skeleton
ligands.
However,
π-extension
strategy
often
results
decreased
solubility,
lower
synthetic
yield,
photoluminescence
quantum
and
so
forth.
this
work,
a
simple
yet
proposed
excited-state
manipulation
2-phenyllepidine-based
iridophosphors.
Surprisingly,
dramatic
tuning
phosphorescence
wavelength
(∼70
nm)
achieved
simply
controlling
position
single
methoxyl
substituent
on
these
An
oxygen-responsive
iridophosphor
featuring
far-red
(660
nm),
long
lifetime
(1.60
μs),
high
singlet
oxygen
yield
(0.73)
employed
realize
accurate
sensing
vitro
vivo,
it
also
shows
therapy
cancer
cells,
making
promising
candidate
image-guided
therapeutic
agent.
This
design
clearly
demonstrates
advantages
designing
novel
long-wavelength
emissive
without
increasing
π-conjugation
ligand.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(21), С. 11633 - 11642
Опубликована: Май 19, 2023
Development
of
highly
efficient
near-infrared
(NIR)-excited
photosensitizers
is
hampered
by
the
fast
nonradiative
vibrational
relaxation
process
regulated
energy
gap
law.
Here,
from
fundamental
perspective
we
propose
that
intermolecular
coupling
well-designed
has
potential
to
facilitate
exciton
delocalization
and
hence
reduce
exciton-vibration
coupling,
thereby
boosting
their
phototherapeutic
efficacy
via
inhibition
pathway.
Such
conceived
NIR-excited
metallo-photosensitizers
(IrHA1
IrHA2)
were
prepared
studied
for
experimental
validation.
The
resulting
iridium
complexes
exhibited
a
little
singlet
oxygen
(1O2)
production
in
monomeric
state,
but
produced
substantially
enhanced
1O2
generation
efficiency
benefiting
decoupling
self-assembly
state.
Particularly,
IrHA2
exhibits
an
unprecedented
high
quantum
yield
54.9%
(FDA-approved
NIR
dye
indocyanine
green:
ΦΔ
=
0.2%)
under
808
nm
laser
irradiation
with
negligible
heat
generation,
probably
attributed
suppression
vibronic
couplings
stretching
mode
acceptor
ligand.
In
phototherapy,
IrHA2-NPs
biocompatibility
low
dark
toxicity
can
induce
substantial
tumor
regression
92.9%
volume
reduction
vivo.
This
self-assembly-induced
strategy
would
offer
effective
approach
design
high-performance
photosensitizers.
Inorganic Chemistry,
Год журнала:
2023,
Номер
62(3), С. 1202 - 1209
Опубликована: Янв. 9, 2023
The
excited-state
manipulation
of
the
phosphorescent
iridium(III)
complexes
plays
a
vital
role
in
their
photofunctional
applications.
development
molecular
design
strategy
promotes
creative
findings
novel
complexes.
current
strategies
for
mainly
depend
on
selective
cyclometalation
ligands
with
ion,
which
is
governed
by
steric
hindrance
ligand
during
cyclometalation.
Herein,
new
(i.e.,
random
strategy)
proposed
effective
cyclometalated
Two
series
and
separable
methoxyl-functionalized
isomeric
are
accessed
one-pot
synthesis
via
cyclometalation,
resulting
dramatic
tuning
phosphorescence
peak
wavelength
(∼57
nm)
electrochemical
properties
attributed
to
high
sensitivity
excited
states
position
methoxyl
group.
These
show
intense
ranging
from
yellow
(567
deep-red
(634
color
photoluminescence
quantum
yields
up
0.99.
emissive
short
decay
lifetimes
further
utilized
as
triplet
emitters
afford
efficient
solution-processed
electroluminescence
reduced
efficiency
roll-offs.
Molecules,
Год журнала:
2023,
Номер
28(3), С. 1231 - 1231
Опубликована: Янв. 27, 2023
Improvements
in
the
design
of
receptors
for
detection
and
quantification
anions
are
desirable
ongoing
field
anion
chemistry,
remarkable
progress
has
been
made
this
direction.
In
regard,
development
luminescent
chemosensors
sensing
is
an
imperative
demanding
sub-area
supramolecular
chemistry.
This
decade,
particular,
witnessed
advancements
based
on
ruthenium
iridium
complexes
by
virtue
their
modular
synthesis
rich
chemical
photophysical
properties,
such
as
visible
excitation
wavelength,
high
quantum
efficiency,
luminescence
intensity,
long
lifetimes
phosphorescence,
large
Stokes
shifts,
etc.
Thus,
review
aims
to
summarize
recent
advances
ruthenium(II)
iridium(III)-based
application
sensing.
addition,
focus
was
devoted
designing
aspects
polypyridyl
these
two
transition
metals
with
different
recognition
motifs,
which
upon
interacting
inorganic
anions,
produces
quantifiable
outputs.