Theranostics,
Год журнала:
2025,
Номер
15(9), С. 3797 - 3820
Опубликована: Март 3, 2025
Background:
Most
anticancer
agents
induce
tumor
apoptosis,
but
they
often
lack
immunogenicity
and
display
limited
success
when
combined
with
mainstream
immunotherapies,
thus
killing
cancer
cells
through
multiple
cell
death
modalities
as
well
switching
immune-off
tumors
to
immune-on
is
a
strategy
great
promise.
To
this
end,
we
developed
CPApoptosis
(cuproptosis,
pyroptosis,
apoptosis)
nano-actuator
for
immunologically
cold
solid
tumors.
Methods:
In
study,
elesclomol
(ES),
mitochondrial
targeting
copper
transporter,
was
encapsulated
within
bacterial
outer
membrane
vesicles
(OMVs).
These
OMVs
were
then
surface-modified
via
metal-phenolic
self-assembly
using
Cu2+
tannic
acid
(TA).
Results:
The
ES
released
from
the
in
pH-dependent
manner.
OMV
activated
non-canonical
pyroptotic
pathway,
leading
rupture.
on
one
hand
transported
mitochondria
cuproptosis
facilitated
by
ES,
other
hand,
reduced
into
Cu+
TA,
which
catalyzed
ROS
production
oxidative
apoptosis.
Simultaneously,
TA
degraded
glutathione
(GSH),
sensitizing
cuproptosis.
multifactorial
mechanisms
led
release
of
immunogenic
factors
lysed
cells,
stimulating
dendritic
maturation
recruiting
cytotoxic
T
cells.
This
immune
response
further
amplified
αPD-L1
antibody
treatment.
Conclusion:
represents
promising
approach
enhance
current
therapies,
inducing
both
robust
response,
potential
long-lasting
protective
effects.
Copper-based
nanoparticles
have
garnered
significant
interest
in
cancer
therapy
due
to
their
ability
induce
oxidative
stress
and
cuproptosis
cells.
However,
antitumor
effectiveness
is
constrained
by
the
dynamic
redox
balance
metabolic
shift
between
phosphorylation
glycolysis.
Here,
a
polydopamine-coated
copper-α-ketoglutaric
acid
(α-KG)
coordination
polymer
nanoparticle
(CKPP)
designed
for
combined
pyroptosis-cuproptosis
immunotherapy
amplifying
reactive
oxygen
species
(ROS)
production
regulating
cellular
metabolism.
The
intracellular
imbalance
achieved
through
synergistic
effects
of
α-KG-induced
mitochondrial
reprogramming,
photothermally
enhanced
superoxide
dismutase-like
activity
polydopamine,
glutathione
depletion
copper
ions.
multifaceted
modulation
results
substantial
increase
ROS
levels,
triggering
subsequent
pyroptosis
Furthermore,
α-KG
shifts
metabolism
from
glycolysis
phosphorylation,
thereby
enhancing
induced
combination
dyshomeostasis
inhibition
potent
enhancement
pyroptosis-cuproptosis-mediated
therapy.
In
murine
model
colorectal
cancer,
CKPP
exhibited
remarkable
anticancer
effect,
achieving
tumor
rate
96.3%
complete
eradication
two
out
five
cases.
Overall,
this
bio-engineered
metal-organic
nanocomposite
demonstrates
potential
treating
immunotherapy.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Advanced Energy Materials,
Год журнала:
2024,
Номер
14(39)
Опубликована: Июль 11, 2024
Abstract
Hydrogen
(H
2
)
is
mainly
produced
using
steam
methane
reforming,
electrolysis,
and
gasification,
which
require
external
energy
special
catalysts.
A
new
catalyst
by
combining
MoS
nanoflowers
(NFs)
with
metal
carbide/nitride
nanosheets
(Mo
CTx
MXene)
to
create
a
nanosheet
bending
moment.
The
@Mo
CT
x
heterostructures
achieve
production
rate
of
1164.8
µmol
g
−1
h
under
an
application
mechanical
force,
4.01
3.06
times
higher
than
Mo
alone,
due
enhanced
charge
transfer
from
's
piezoelectricity
conductivity.
This
study
introduces
pioneering
methodology
that
harnesses
gravitational
as
continuous
simulated
peristaltic
pump,
drive
the
piezocatalytic
hydrogen
evolution
reaction
(HER),
achieving
notable
454.1
over
24
hours
demonstrating
sustained
capability
for
generation.
theoretical
calculation
results
validate
piezoelectric
potential
in
water‐flow‐pressure
triggered
HER
systems.
system,
assuming
powered
Hoover
Dam,
will
produce
290.9
kmoles
per
ton
daily,
equivalent
utilizing
19
150
kWh
electrocatalytic
system.
gravity‐driven
water
flow
piezocatalysts
H
generation
demonstrates
superior
efficiency
eliminating
common
thermal
conversion
losses,
marking
significant
breakthrough
sustainable
technologies.
HA-TPP
NHs
constructed
by
chemical
crosslinking
fixing
photosensitizers
for
reducing
the
aggregation
of
produce
more
singlet
oxygen
and
have
a
better
killing
effect
on
tumor
cells,
compared
to
assembling
NPs.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Piezoelectric
semiconductor
nanomaterials
have
attracted
considerable
interest
in
piezocatalytic
tumor
treatment.
However,
therapy
encounters
obstacles
such
as
suboptimal
piezoelectric
responses,
rapid
electron‐hole
recombination,
inefficient
energy
harvesting,
and
the
complexities
of
microenvironment.
In
this
study,
sulfur
vacancy‐engineered
cobalt
(Co)
single‐atom
doped
molybdenum
disulfide
(SA‐Co@MoS
2
)
nanoflowers
are
strategically
designed,
which
exhibit
enhanced
effects.
Specifically,
introduction
Co
single
atom
not
only
induces
lattice
distortion
out‐of‐plane
polarization
but
also
leads
to
formation
numerous
vacancies.
These
changes
collectively
narrow
intrinsic
bandgap
material,
facilitating
effective
separation
migration
charge
carriers,
enabling
efficient
production
reactive
oxygen
species
under
ultrasound
stimulation.
Additionally,
SA‐Co@MoS
demonstrate
improved
enzymatic
activity
glutathione
depletion
capabilities
attributed
mixed
valence
states
Co,
intensifying
oxidative
stress
cells,
leading
cell
cycle
arrest
apoptosis,
while
inactivation
peroxidase
4
ferroptosis.
Both
vitro
vivo
results
indicate
that
can
significantly
eliminate
cells.
This
study
offers
valuable
insights
into
exploration
doping‐enhanced
sonosensitizers
for
cancer
treatment,
potentially
paving
way
advancements
field
synergistic
enzyodynamic
therapy.
Cuproptosis,
a
distinct
cell
death
pathway,
has
been
integrated
into
nanomedicine
for
disease
theranostics.
However,
current
nanosystems
inducing
cuproptosis
rely
on
exogenous
toxic
copper
ions,
limiting
the
scope
of
biomaterials.
Developing
nanoplatforms
that
induce
without
holds
substantial
promise.
Here,
we
engineered
two-dimensional
iron
(Fe)
single-atom–doped
molybdenum
disulfide
(MoS
2
)
piezocatalyst
(Fe-MoS
tumor
therapy.
Incorporating
single
Fe
atoms
enhances
MoS
piezoelectric
polarization
via
charge
redistribution
and
modulates
Mo
oxidation
states,
enabling
multifaceted
enzymatic
activities,
including
peroxidase-,
glutathione
oxidase–,
oxidase-,
catalase-like
activities.
Upon
ultrasound
stimulation,
Fe-MoS
nanocatalyst
generates
reactive
oxygen
species
depletes
synergistic
piezocatalytic
enzyocatalytic
effects,
disrupting
ion
homeostasis
cuproptosis,
concurrently
triggering
ferroptosis
ferritinophagy,
which
collectively
suppression.
This
study
represents
first
paradigm
to
introduce
copper-free
initiating
substantially
advancing
applications
in
