Advanced Materials,
Год журнала:
2023,
Номер
36(1)
Опубликована: Окт. 21, 2023
Abstract
Cancer
immunotherapy
has
become
a
promising
method
for
cancer
treatment,
bringing
hope
to
advanced
patients.
However,
immune‐related
adverse
events
caused
by
also
bring
heavy
burden
Semiconducting
polymer
nanoparticles
(SPNs)
as
an
emerging
nanomaterial
with
high
biocompatibility,
can
eliminate
tumors
and
induce
tumor
immunogenic
cell
death
through
different
therapeutic
modalities,
including
photothermal
therapy,
photodynamic
sonodynamic
therapy.
In
addition,
SPNs
work
functional
nanocarrier
synergize
variety
of
immunomodulators
amplify
anti‐tumor
immune
responses.
this
review,
SPNs‐based
combination
is
comprehensively
summarized
according
the
SPNs’
modalities
type
loaded
immunomodulators.
The
in‐depth
understanding
existing
will
hopefully
inspire
design
more
novel
nanomaterials
potent
effects,
ultimately
promote
their
clinical
translation.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(41), С. 19038 - 19050
Опубликована: Окт. 10, 2022
A
rationally
designed
immunostimulant
(CC@SiO2-PLG)
with
a
photoactivatable
immunotherapeutic
function
for
synergetic
tumor
therapy
is
reported.
This
CC@SiO2-PLG
nanoplatform
comprises
catalase
and
photosensitizer
(Ce6)
co-encapsulated
in
silica
capsule,
to
which
an
conjugated
through
reactive
oxygen
species-cleavable
linker.
After
accumulating
tissue,
generates
O2
relieve
hypoxia
promotes
the
production
of
singlet
(1O2)
upon
laser
irradiation,
resulting
not
only
destruction
but
also
release
tumor-associated
antigens
(TAAs).
Simultaneously,
linker
breakage
by
photoproduced
1O2
leads
remote-controlled
indoleamine
2,3-dioxygenase
(IDO)
inhibitor
from
consequent
immunosuppressive
microenvironment
reversion.
The
released
TAAs
conjunction
inhibition
IDO-mediated
tryptophan/kynurenine
metabolic
pathway
induced
boosted
antitumor
immune
response
CC@SiO2-PLG-mediated
phototherapy.
Therefore,
growth
primary/distant
tumors
lung
metastases
mouse
xenograft
model
was
greatly
inhibited,
achievable
phototherapy
alone.
ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 15072 - 15085
Опубликована: Авг. 15, 2022
Nanosized
artificial
antigen-presenting
cells
(aAPCs),
synthetic
immune
cell
mimics
that
aim
to
activate
T
ex
or
in
vivo,
offer
an
effective
alternative
cellular
immunotherapies.
However,
comprehensive
studies
delineate
the
effect
of
nano-aAPC
topology,
including
nanoparticle
morphology
and
ligand
density,
are
lacking.
Here,
we
systematically
studied
topological
effects
polymersome-based
aAPCs
on
activation.
We
employed
aAPC
library
created
from
biodegradable
poly(ethylene
glycol)-block-poly(d,l-lactide)
(PEG-PDLLA)
polymersomes
with
spherical
tubular
shape
variable
sizes,
which
were
functionalized
αCD3
αCD28
antibodies
at
controlled
densities.
Our
results
indicate
high
density
leads
enhancement
activation,
can
be
further
augmented
by
employing
larger
size.
At
low
both
polymersome
size
was
more
pronounced,
showing
large
elongated
better
compared
their
smaller
counterparts.
This
study
demonstrates
capacity
as
highlights
role
topology
for
rational
design.
Advanced Materials,
Год журнала:
2023,
Номер
36(1)
Опубликована: Окт. 21, 2023
Abstract
Cancer
immunotherapy
has
become
a
promising
method
for
cancer
treatment,
bringing
hope
to
advanced
patients.
However,
immune‐related
adverse
events
caused
by
also
bring
heavy
burden
Semiconducting
polymer
nanoparticles
(SPNs)
as
an
emerging
nanomaterial
with
high
biocompatibility,
can
eliminate
tumors
and
induce
tumor
immunogenic
cell
death
through
different
therapeutic
modalities,
including
photothermal
therapy,
photodynamic
sonodynamic
therapy.
In
addition,
SPNs
work
functional
nanocarrier
synergize
variety
of
immunomodulators
amplify
anti‐tumor
immune
responses.
this
review,
SPNs‐based
combination
is
comprehensively
summarized
according
the
SPNs’
modalities
type
loaded
immunomodulators.
The
in‐depth
understanding
existing
will
hopefully
inspire
design
more
novel
nanomaterials
potent
effects,
ultimately
promote
their
clinical
translation.
