Despite
immunotherapy
emerging
as
a
vital
approach
to
improve
cancer
treatment,
the
activation
of
efficient
immune
responses
is
still
hampered
by
immunosuppression,
especially
due
low
tumor
immunogenicity.
Immunogenic
cell
death
(ICD)
promising
strategy
reshape
microenvironment
(TME)
for
achieving
high
Various
stimuli
are
able
effectively
initiate
their
specific
ICD
utilizing
corresponding
ICD-inducer.
However,
ICD-guided
antitumor
effects
usually
impaired
various
biological
barriers
and
TME-associated
resistance.
Biomimetic
active
materials
being
extensively
explored
guided
agents
unique
advantages.
In
this
review,
two
major
strategies
systematically
introduced
that
have
been
employed
exploit
biomimetic
immunotherapy,
mainly
including
naive
organism-derived
nanoagents
engineered
bioactive
platforms.
This
review
outlines
recent
advances
in
field
at
physiotherapy,
chemotherapy,
biotherapy
induction.
The
challenges
applications
further
discussed
future
clinical
practice.
provides
an
overview
targeting
immunoregulation
treatment
can
contribute
advanced
combination
therapy.
Abstract
Tumor
cells
may
be
eliminated
by
increasing
their
temperature.
This
is
achieved
via
photothermal
therapy
(PTT)
penetrating
the
tumor
tissue
with
near‐infrared
light
and
converting
energy
into
heat
using
agents.
Copper
sulfide
nanoparticles
(CuS
NPs)
are
commonly
used
as
PTAs
in
PTT.
In
this
review,
we
aimed
to
discuss
synergism
between
PTT
CuS
NPs
other
therapies
such
chemotherapy,
radiotherapy,
dynamic
(photodynamic,
chemodynamic,
sonodynamic
therapy),
immunotherapy,
gene
therapy,
gas
magnetic
hyperthermia.
Furthermore,
summarized
results
obtained
a
combination
of
two
treatments
at
least
therapies,
one
included
therapies.
Finally,
benefits
drawbacks
various
therapeutic
options
state
art
CuS‐based
provided
future
directions
for
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Ноя. 16, 2022
Abstract
With
the
economy's
globalization
and
population's
aging,
cancer
has
become
leading
cause
of
death
in
most
countries.
While
imposing
a
considerable
burden
on
society,
high
morbidity
mortality
rates
have
continuously
prompted
researchers
to
develop
new
oncology
treatment
options.
Anti-tumor
regimens
evolved
from
early
single
surgical
combined
(or
not)
chemoradiotherapy
then
current
stage
tumor
immunotherapy.
Tumor
immunotherapy
undoubtedly
pulled
some
patients
back
death.
However,
this
strategy
activating
or
boosting
body's
immune
system
hardly
benefits
patients.
It
is
limited
by
low
bioavailability,
response
rate
severe
side
effects.
Thankfully,
rapid
development
nanotechnology
broken
through
bottleneck
problem
anti-tumor
Multifunctional
nanomaterials
can
not
only
kill
tumors
combining
drugs
but
also
be
designed
enhance
immunity
thus
achieve
multi-treatment
effect.
worth
noting
that
variety
nanomaterials,
their
modifiability,
diversity
combinations
allow
them
shine
antitumor
In
paper,
several
nanobiotics
commonly
used
at
are
discussed,
they
activate
with
unique
advantages.
conclusion,
we
reviewed
recent
advances
based
such
as
biological
cell
membrane
modification,
self-assembly,
mesoporous,
metal
hydrogels,
explore
directions
strategies
for
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(26)
Опубликована: Авг. 4, 2023
Abstract
The
application
of
nanomaterials
in
healthcare
has
emerged
as
a
promising
strategy
due
to
their
unique
structural
diversity,
surface
properties,
and
compositional
diversity.
In
particular,
have
found
significant
role
improving
drug
delivery
inhibiting
the
growth
metastasis
tumor
cells.
Moreover,
recent
studies
highlighted
potential
modulating
microenvironment
(TME)
enhancing
activity
immune
cells
improve
therapy
efficacy.
Various
types
are
currently
utilized
carriers,
immunosuppressants,
activators,
immunoassay
reagents,
more
for
immunotherapy.
Necessarily,
used
immunotherapy
can
be
grouped
into
two
categories:
organic
inorganic
nanomaterials.
Though
both
shown
ability
achieve
purpose
immunotherapy,
composition
properties
result
differences
mechanisms
modes
action.
Organic
further
divided
polymers,
cell
membranes,
nanoemulsion‐modified,
hydrogel
forms.
At
same
time,
broadly
classified
nonmetallic
metallic
current
work
aims
explore
action
these
different
prospects
promoting
Advanced Drug Delivery Reviews,
Год журнала:
2023,
Номер
200, С. 115028 - 115028
Опубликована: Июль 28, 2023
Lipid-based
nanocarriers
have
been
extensively
investigated
for
their
application
in
drug
delivery.
Particularly,
liposomes
are
now
clinically
established
treating
various
diseases
such
as
fungal
infections.
In
contrast,
extracellular
vesicles
(EVs)
-
small
cell-derived
nanoparticles
involved
cellular
communication
just
recently
sparked
interest
carriers
but
development
is
still
at
the
preclinical
level.
To
drive
this
further,
methods
and
technologies
exploited
context
of
liposome
research
should
be
applied
domain
EVs
to
facilitate
accelerate
clinical
translation.
One
crucial
steps
EV-based
therapeutics
designing
them
proper
dosage
forms
specific
applications.
This
review
offers
a
comprehensive
overview
state-of-the-art
polysaccharide-based
hydrogel
platforms
designed
artificial
natural
with
delivery
skin.
We
discuss
physicochemical
biological
properties
try
create
sound
basis
optimization
EV-embedded
hydrogels
versatile
therapeutic
avenues.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(34), С. 40267 - 40279
Опубликована: Авг. 18, 2023
Transdermal
cancer
therapy
faces
great
challenges
in
clinical
practice
due
to
the
low
drug
transdermal
efficiency
and
unsatisfactory
effect
of
monotherapy.
Herein,
we
develop
a
novel
bubble
pump
microneedle
system
(BPMN-CuS/DOX)
by
embedding
sodium
bicarbonate
(NaHCO3)
into
hyaluronic
acid
microneedles
(MNs)
loaded
with
fucoidan-based
copper
sulfide
nanoparticles
(Fuc-CuS
NPs)
doxorubicin
(DOX).
BPMN-CuS/DOX
can
generate
CO2
bubbles
triggered
an
acidic
tumor
microenvironment
for
deep
rapid
intradermal
delivery.
Fuc-CuS
NPs
exhibit
excellent
photothermal
Fenton-like
catalytic
activity,
producing
more
reactive
oxygen
species
(ROS)
(PTT)
chemodynamic
(CDT),
which
enhances
antitumor
efficacy
DOX
reduces
dosage
its
chemotherapy
(CT).
Simultaneously,
increases
intracellular
hydrogen
peroxide
(H2O2)
supplementation
promotes
sustained
production
ROS.
significantly
inhibits
melanoma
both
vitro
vivo
combination
CDT,
PTT,
CT.
In
short,
our
study
effectiveness
delivery
constructing
BPMNs
provides
promising
strategy
treatment
multiple
therapies.
In
recent
years,
cancer
immunotherapy
has
undergone
a
transformative
shift
toward
personalized
and
targeted
therapeutic
strategies.
Bacteria-derived
outer
membrane
vesicles
(OMVs)
have
emerged
as
promising
adaptable
platform
for
due
to
their
unique
properties,
including
natural
immunogenicity
the
ability
be
engineered
specific
purposes.
this
review,
comprehensive
overview
is
provided
of
state-of-the-art
techniques
methodologies
employed
in
engineering
versatile
OMVs
immunotherapy.
Beginning
by
exploring
biogenesis
composition
OMVs,
unveiling
intrinsic
immunogenic
properties
appeal.
Subsequently,
innovative
approaches
engineer
are
delved
into,
ranging
from
genetic
parent
bacteria
incorporation
functional
molecules.
The
importance
rational
design
strategies
highlighted
enhance
specificity
allowing
tailoring
diverse
types.
Furthermore,
insights
into
clinical
studies
potential
challenges
utilizing
vaccines
or
adjuvants
also
provided,
offering
assessment
current
landscape
future
prospects.
Overall,
review
provides
valuable
researchers
involved
rapidly
evolving
field
immunotherapy,
roadmap
harnessing
full
treatment.
