Extended Conjugation Tuning Carbon Nitride for Non‐sacrificial H₂O₂Photosynthesis and Hypoxic Tumor Therapy**

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(43)

Опубликована: Авг. 8, 2022

Abstract Artificial photocatalysis offers a clean approach for producing H 2 O . However, the poor selectivity and activity of production hamper traditional industrial applications emerging photodynamic therapy (PDT)/chemodynamic (CDT). Herein, we report C 5 N photocatalyst with conjugated C=N linkage selective efficient non‐sacrificial in both normoxic hypoxic systems. The strengthened delocalization π‐electrons by linkers downshifted band position, thermodynamically eliminating side evolution reaction kinetically promoting water oxidation. As result, had competitive solar‐to‐chemical conversion efficiency 0.55 % overall exhibited far highest under conditions (698 μM h −1 ). was further applied to PDT/CDT outstanding performance apparent cancer cell death synchronous bioimaging. study sheds light on photosynthesis carbon nitrides health applications.

Язык: Английский

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Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses

ACS Nano, Год журнала: 2022, Номер 16(12), С. 19691 - 19721

Опубликована: Ноя. 15, 2022

The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires innovative solutions for its congenitally deficient shadow penetration the visible-light excitation. X-ray-induced (X-PDT) has been proven to be a successful technique reforming conventional PDT deep-seated tumors by creatively utilizing penetrating X-rays as external excitation sources and witnessed rapid developments over past several years. Beyond proof-of-concept demonstration, recent advances X-PDT have exhibited trend minimizing X-ray radiation doses quite low values. As such, scintillating materials used bridge photosensitizers play significant role, do diverse well-designed irradiation modes smart strategies improving tumor microenvironment. Here this review, we provide comprehensive summary achievements highlight trending efforts using radiation. We first describe concept relationships with radiodynamic radiotherapy then dissect mechanism absorption conversion materials, reactive oxygen species evaluation X-PDT, side effects clinical concerns on Finally, discuss detailed overview progress regarding low-dose present perspectives possible translation. It is expected that pursuit will facilitate breakthroughs, both fundamentally clinically, effective treatment near future.

Язык: Английский

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Enzyme-Responsive Double-Locked Photodynamic Molecular Beacon for Targeted Photodynamic Anticancer Therapy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(13), С. 7361 - 7375

Опубликована: Март 24, 2023

An advanced photodynamic molecular beacon (PMB) was designed and synthesized, in which a distyryl boron dipyrromethene (DSBDP)-based photosensitizer Black Hole Quencher 3 moiety were connected via two peptide segments containing the sequences PLGVR GFLG, respectively, of cyclic peptide. These short are well-known substrates matrix metalloproteinase-2 (MMP-2) cathepsin B, both overexpressed wide range cancer cells either extracellularly (for MMP-2) or intracellularly B). Owing to efficient Förster resonance energy transfer between components, this PMB fully quenched native form. Only upon interaction with MMP-2 buffer solution cells, cleaved specifically, components could be completely separated, thereby restoring activities DSBDP moiety. This also activated tumors, it effectively suppressed tumor growth A549 tumor-bearing nude mice laser irradiation without causing notable side effects. In particular, did not cause skin photosensitivity, is very common effect therapy (PDT) using conventional "always-on" photosensitizers. The overall results showed that "double-locked" functioned as biological AND logic gate only unlocked by coexistence tumor-associated enzymes, greatly enhance specificity PDT.

Язык: Английский

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Biodegradable NIR‐II Pseudo Conjugate Polymeric Nanoparticles Amplify Photodynamic Immunotherapy via Alleviation of Tumor Hypoxia and Tumor‐Associated Macrophage Reprogramming

Advanced Materials, Год журнала: 2023, Номер 35(31)

Опубликована: Июнь 7, 2023

Photodynamic therapy (PDT) has achieved great success in cancer treatment. Despite its promise, the efficacy of photodynamic immunotherapy can be limited by hypoxia solid tumors which is closely related to abnormal tumor vasculature. These vasculatures are a hallmark most and facilitate immune evasion. Therefore, vascular normalization developed as promising strategy overcome hypoxia, resulting improved therapy. Here, NIR-II bio-degradable pseudo-conjugate polymer (PSP)-based designed deliver agent, i.e., regorafenib (Reg) nanoparticles (NP-PDT@Reg). NP-PDT@Reg under 808 nm laser irradiation (NP-PDT@Reg + L) efficiently release Reg improve via normalization, making more oxygen enter tumors. Moreover, L further result generation reactive species (ROS) eradicate cells while inducing immunogenic cell death (ICD) activate anti-tumor responses. In addition, reprogram TAM from pro-tumor M2 phenotype tumor-killing M1 well, thereby reversing immunosuppressive microenvironment. Taken together, current study provides an innovative perspective on development novel nanomaterials limitations immunotherapy.

Язык: Английский

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An ER‐targeted, Viscosity‐sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)

Опубликована: Янв. 10, 2024

The concept of molecular design, integrating diagnostic and therapeutic functions, aligns with the general trend modern medical advancement. Herein, we rationally designed smart molecule ER-ZS for endoplasmic reticulum (ER)-targeted diagnosis treatment in cell animal models by combining hemicyanine dyes ER-targeted functional groups (p-toluenesulfonamide). Owing to its ability target ER a highly specific response viscosity, demonstrated substantial fluorescence turn-on only after binding ER, independent other physiological environments. In addition, ER-ZS, being small molecule, allows nonalcoholic fatty liver disease (NAFLD) via imaging based on high stress. Importantly, is type I photosensitizer, producing O

Язык: Английский

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An Activatable Phototheranostic Probe for Anti‐hypoxic Type I Photodynamic‐ and Immuno‐Therapy of Cancer

Advanced Materials, Год журнала: 2023, Номер 36(4)

Опубликована: Авг. 29, 2023

Photodynamic therapy (PDT), which utilizes type I photoreactions, has great potential as an effective cancer treatment because of its hypoxia-tolerant superiority over the commonly used II pathway. A few photosensitizers are exploited; however, they majorly induce cytotoxicity and possess poor tumor specificity low-efficient theranostics. To resolve this issue, herein aminopeptidase N (APN)-activated phototheranostic probe (CyA) is reported for anti-hypoxic PDT in conjunction with immunotherapy treatment. CyA can specifically activate near-infrared fluorescence, photoacoustic signals, phototoxicity following APN-induced substrate cleavage subsequent generation active molecules (such CyBr). endows specific imaging capabilities toward cells overexpressing APN under both normoxia hypoxia. In addition, locally activatable induces systemic antitumor immune responses. More importantly, integration localized activated evokes enhanced therapeutic effects improved inhibition efficiency live mice compared individual treatments. This study aims to present combination therapy.

Язык: Английский

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Hypoxia signaling in cancer: Implications for therapeutic interventions

MedComm, Год журнала: 2023, Номер 4(1)

Опубликована: Янв. 23, 2023

Abstract Hypoxia is a persistent physiological feature of many different solid tumors and key driver malignancy, in recent years, it has been recognized as an important target for cancer therapy. occurs the majority due to poor vascular oxygen supply that not sufficient meet needs rapidly proliferating cells. A hypoxic tumor microenvironment (TME) can reduce effectiveness other therapies, such radiotherapy, chemotherapy, immunotherapy. In this review, we discuss critical role hypoxia development, including metabolism, immunity, angiogenesis. The treatment methods TME are summarized, hypoxia‐targeted therapy improving oxygenation by alleviating itself. Hyperoxia be used improve tissue partial pressure relieve hypoxia. We focus on underlying mechanisms hyperoxia their impact current therapies prospects treatment.

Язык: Английский

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Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Advanced Materials, Год журнала: 2023, Номер 36(17)

Опубликована: Авг. 19, 2023

Abstract Recently, many organic optoelectronic materials (OOMs), especially those used in light‐emitting diodes (OLEDs), solar cells (OSCs), and field‐effect transistors (OFETs), are explored for biomedical applications including imaging photoexcited therapies. In this review, recently developed OOMs fluorescence imaging, photoacoustic photothermal therapy, photodynamic summarized. Relationships between their molecular structures, nanoaggregation photophysical mechanisms, properties various discussed. Mainly four kinds of covered: thermally activated delayed OLEDs, conjugated small molecules polymers OSCs, charge‐transfer complexes OFETs. Based on the unique optical properties, excitation light wavelength exciton dynamics, they respectively exploited suitable applications. This review is intended to serve as a bridge researchers area devices Moreover, it provides guidance selecting or modifying high‐performance uses. Current challenges future perspectives also discussed with hope inspiring further development efficient

Язык: Английский

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External physical field‐driven nanocatalytic cancer therapy

BMEMat, Год журнала: 2023, Номер 1(1)

Опубликована: Фев. 14, 2023

Abstract Recently, variable nanocatalysts have provided novel, highly selective, minimally invasive strategies driven by external physical fields for cancer therapy. In the catalytic reaction, less toxic or nontoxic substances can be in situ converted into agents suppression. this review, we systematically summarize therapy based on different types of fields, including light, ultrasound, electricity, temperature, X‐ray, magnetic field, and microwave. The properties, mechanisms, advantages corresponding are also introduced. Importantly, considering rapid development nanomedicine, research progress is discussed. Finally, remaining challenges outlooks that faced outlined. We believe emerging fields‐driven nanocatalytic will provide a new avenue treatment.

Язык: Английский

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Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy

Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215560 - 215560

Опубликована: Ноя. 27, 2023

Язык: Английский

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