Hypoxia signaling in cancer: Implications for therapeutic interventions

MedComm, Год журнала: 2023, Номер 4(1)

Опубликована: Янв. 23, 2023

Abstract Hypoxia is a persistent physiological feature of many different solid tumors and key driver malignancy, in recent years, it has been recognized as an important target for cancer therapy. occurs the majority due to poor vascular oxygen supply that not sufficient meet needs rapidly proliferating cells. A hypoxic tumor microenvironment (TME) can reduce effectiveness other therapies, such radiotherapy, chemotherapy, immunotherapy. In this review, we discuss critical role hypoxia development, including metabolism, immunity, angiogenesis. The treatment methods TME are summarized, hypoxia‐targeted therapy improving oxygenation by alleviating itself. Hyperoxia be used improve tissue partial pressure relieve hypoxia. We focus on underlying mechanisms hyperoxia their impact current therapies prospects treatment.

Язык: Английский

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Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Янв. 5, 2024

This review article explores the dynamic field of radiopharmaceuticals, where innovative developments arise from combining radioisotopes and pharmaceuticals, opening up exciting therapeutic possibilities. The in-depth exploration covers targeted drug delivery, delving into passive targeting through enhanced permeability retention, as well active using ligand-receptor strategies. also discusses stimulus-responsive release systems, which orchestrate controlled release, enhancing precision effectiveness. A significant focus is placed on crucial role radiopharmaceuticals in medical imaging theranostics, highlighting their contribution to diagnostic accuracy image-guided curative interventions. emphasizes safety considerations strategies for mitigating side effects, providing valuable insights addressing challenges achieving precise delivery. Looking ahead, nanoparticle formulations cutting-edge innovations next-generation showcasing potential applications. Real-world examples are presented case studies, including use radiolabelled antibodies solid tumors, peptide receptor radionuclide therapy neuroendocrine intricate management bone metastases. concluding perspective envisions future trajectory anticipating a harmonious integration medicine artificial intelligence. vision foresees an era aligns seamlessly with scientific advancements, ushering new epoch marked by fusion resonance visionary progress.

Язык: Английский

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The changing treatment landscape of EGFR-mutant non-small-cell lung cancer

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 29, 2024

Язык: Английский

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Functional Relevance of Extracellular Vesicle-Derived Long Non-Coding and Circular RNAs in Cancer Angiogenesis

Non-Coding RNA, Год журнала: 2024, Номер 10(1), С. 12 - 12

Опубликована: Фев. 6, 2024

Extracellular vesicles (EVs) are defined as subcellular structures limited by a bilayer lipid membrane that function important intercellular communication transporting active biomolecules, such proteins, amino acids, metabolites, and nucleic including long non-coding RNAs (lncRNAs). These cargos can effectively be delivered to target cells induce highly variable response. LncRNAs functional composed of at least 200 nucleotides do not code for proteins. Nowadays, lncRNAs circRNAs known play crucial roles in many biological processes, plethora diseases cancer. Growing evidence shows an presence lnc- EVs, generating downstream responses ultimately affect cancer progression mechanisms, angiogenesis. Moreover, studies have revealed some tumor promote angiogenesis secreting which endothelial take up new vessel formation. In this review, we aim summarize the bioactive EVs with cargo their effect on Also, discuss future clinical strategies treatment based current knowledge circ- lncRNA-EVs.

Язык: Английский

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The future of plant based green carbon dots as cancer Nanomedicine: From current progress to future Perspectives and beyond

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Фев. 1, 2024

The emergence of carbon dots (CDs) as anticancer agents had sparked a transformation in cancer research and treatment strategies. These fluorescent CDs, initially introduced the early 2000 s, possess exceptional biocompatibility, tunable fluorescence, surface modification capabilities, positioning them promising tools biomedical applications.

Язык: Английский

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“Find Me” and “Eat Me” signals: tools to drive phagocytic processes for modulating antitumor immunity

Cancer Communications, Год журнала: 2024, Номер 44(7), С. 791 - 832

Опубликована: Июнь 23, 2024

Phagocytosis, a vital defense mechanism, involves the recognition and elimination of foreign substances by cells. Phagocytes, such as neutrophils macrophages, rapidly respond to invaders; macrophages are especially important in later stages immune response. They detect "find me" signals locate apoptotic cells migrate toward them. Apoptotic then send "eat that recognized phagocytes via specific receptors. "Find can be strategically harnessed modulate antitumor immunity support cancer therapy. These signals, calreticulin phosphatidylserine, mediate potent pro-phagocytic effects, thereby promoting engulfment dying or their remnants neutrophils, dendritic inducing tumor cell death. This review summarizes phagocytic including concepts, signaling mechanisms, involved ligands, functions. Furthermore, we delineate relationships between molecules tumors, roles these initiation, progression, diagnosis, patient prognosis. The interplay with biology is elucidated, approaches enhance explored. Additionally, novel therapeutic strategies combine better bridge innate adaptive treatment patients discussed.

Язык: Английский

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Progression of m6A in the tumor microenvironment: hypoxia, immune and metabolic reprogramming

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Июль 20, 2024

Abstract Recently, N6-methyladenosine (m 6 A) has aroused widespread discussion in the scientific community as a mode of RNA modification. m A comprises writers, erasers, and readers, which regulates production, nuclear export, translation is very important for human health. large number studies have found that regulation closely related to occurrence invasion tumors, while homeostasis function tumor microenvironment (TME) determine development tumors some extent. TME composed variety immune cells (T cells, B etc.) nonimmune (tumor-associated mesenchymal stem (TA-MSCs), cancer-associated fibroblasts (CAFs), etc.). Current suggest involved regulating various TME, thereby affecting progression. In this manuscript, we present composition relationship between methylation characteristic changes role potential therapeutic strategies provide new perspectives better treatment clinical work.

Язык: Английский

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Hypoxia-activated oxidative stress mediates SHP2/PI3K signaling pathway to promote hepatocellular carcinoma growth and metastasis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 10, 2025

Hepatocellular carcinoma is considered to be the fifth most rampant type of cancer in whole world and has a high death rate. The hypoxic microenvironment one typical features tumor tissues an important impact on activity multiple signaling pathways. It great significance study effects hypoxia pathophysiological processes molecular mechanisms HCC. Signalling pathways associated with SHP2 were analysed using bioinformatics. Detection relevant protein expression Western blotting. Tube formation assay was used evalution angiogenic potential. concentrations MDA SOD measured by ELISA. cell migration invasion ability scratch wound transwell SMMC-7721, HepG2 Huh-7 cells. effect growth hepatocellular examined subcutaneous graft tumors HE staining experiments nude mice. Bioinformatics analysis negatively correlates PI3K signalling pathway. Hypoxia promotes concentration inhibited SOD. may up-regulate NOX2, NOX4 p-PI3K down-regulate treatment p-SHP2. Compared NC group, p-SHP2 KD group p-PI3K, HIF1α, COX2, FOXM1, β-catenin MMP9 promoted. However, differences between two groups abolished after addition inhibitor. angiogenesis, abilities significantly increased compared group. Similarly, inhibitor, difference these eliminated. can promote carcinoma. activate oxidative stress-mediated SHP2/PI3K pathway migration, carcinoma, thus advancing development

Язык: Английский

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Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июнь 8, 2023

Abstract Cancer cell metabolism contributes to the establishment of an immunosuppressive tumor microenvironment. Aberrant expression CD73, a critical enzyme in ATP metabolism, on surface results extracellular accumulation adenosine, which exhibits direct inhibitory effects tumor-infiltrating lymphocytes. However, little is known about influence CD73 negative immune regulation-associated signaling molecules and transduction pathways inside cells. This study aims demonstrate moonlighting functions immunosuppression pancreatic cancer, ideal model characterized by complex crosstalk among cancer microenvironment, immunotherapeutic resistance. The synergistic effect CD73-specific drugs combination with checkpoint blockade observed multiple models. Cytometry time-of-flight analysis shows that inhibition reduces Tregs cancer. Tumor cell-autonomous found facilitate Treg recruitment, CCL5 identified as significant downstream effector using integrated proteomic transcriptomic analyses. transcriptionally upregulates through cell-autocrine adenosine–Adora2a signaling-mediated activation p38–STAT1 axis, recruiting tumors causing Together, this highlights CD73–adenosine controls tumor-autonomous -autocrine manner.

Язык: Английский

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Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 6945 - 6945

Опубликована: Апрель 8, 2023

Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer, with clinical features high metastatic potential, susceptibility to relapse, and poor prognosis. TNBC lacks expression estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2). It characterized by genomic transcriptional heterogeneity a tumor microenvironment (TME) presence levels stromal tumor-infiltrating lymphocytes (TILs), immunogenicity, an important immunosuppressive landscape. Recent evidence suggests that metabolic changes in TME play key role molding development impacting immune cell fractions, composition, activation. Hence, complex inter-talk between signaling exists, highlighting possibility uncovering investigating novel therapeutic targets. A better understanding interaction cells, underlying molecular mechanisms cell–cell communication signaling, may uncover additional targets for strategies treatment. In this review, we aim discuss reprogramming, linking these potential targetable generate new, physical science-inspired translational insights cure TNBC.

Язык: Английский

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