Biomaterials Advances, Год журнала: 2022, Номер 144, С. 213232 - 213232
Опубликована: Дек. 5, 2022
Язык: Английский
Pharmaceutics, Год журнала: 2023, Номер 15(6), С. 1677 - 1677
Опубликована: Июнь 8, 2023
Achieving precise cancer theranostics necessitates the rational design of smart nanosystems that ensure high biological safety and minimize non-specific interactions with normal tissues. In this regard, “bioinspired” membrane-coated have emerged as a promising approach, providing versatile platform for development next-generation nanosystems. This review article presents an in-depth investigation into potential these targeted theranostics, encompassing key aspects such cell membrane sources, isolation techniques, nanoparticle core selection, approaches coating cores membrane, characterization methods. Moreover, underscores strategies employed to enhance multi-functionality nanosystems, including lipid insertion, hybridization, metabolic engineering, genetic modification. Additionally, applications bioinspired in diagnosis therapeutics are discussed, along recent advances field. Through comprehensive exploration provides valuable insights their theranostics.
Язык: Английский
Процитировано
29
Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)
Опубликована: Июнь 23, 2023
Abstract Hematologic malignancies (HMs) pose a serious threat to patients’ health and life, the five-year overall survival of HMs remains low. The lack understanding pathogenesis complex clinical symptoms brings immense challenges diagnosis treatment HMs. Traditional therapeutic strategies for include radiotherapy, chemotherapy, targeted therapy hematopoietic stem cell transplantation. Although immunotherapy have made considerable progress in last decade, nearly half patients still relapse or suffer from drug resistance. Recently, studies emerged that nanomaterials, nanotechnology nanomedicine show great promise cancer by enhancing targeting, reducing toxicity side effects boosting immune response promote durable immunological memory. In this review, we summarized recently developed nanomedicines against then proposed emerging future designment treat based on urgent needs technological progress.
Язык: Английский
Процитировано
27
Biomaterials Research, Год журнала: 2023, Номер 27(1)
Опубликована: Фев. 9, 2023
Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth spread abnormal cells body," fails to convey intricate interaction between many entities involved cancer. Recent advancements field cancer research have shed light on role played individual tumor microenvironment as whole development progression. This breakthrough enables utilization components biological tools, opening new possibilities. article delves deeply into concept "tumor-derived systems", an umbrella term for tools sourced from aid combatting it. It includes cell membrane-coated nanoparticles (for theranostics), extracellular vesicles diagnosis/therapy), lysates vaccine development), engineered cells/organoids research). review seeks offer complete overview tumor-derived materials are utilized research, well their current stages implementation. aimed primarily at researchers working interface biology biomedical engineering, it provides vital insights this fast-growing topic.
Язык: Английский
Процитировано
26
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2071 - 2071
Опубликована: Фев. 8, 2024
Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle faces challenges such as short circulation time immune recognition. To tackle these issues, cell membrane-coated nanoparticles have been suggested practical alternative. The production process involves three main stages: lysis membrane fragmentation, isolation, coating. Cell membranes are typically fragmented using hypotonic with homogenization sonication. Subsequent fragments isolated through multiple centrifugation steps. Coating can be achieved extrusion, sonication, combination of both methods. Notably, this analysis reveals the absence universally applicable method for coating, stages differ significantly their procedures. This review explores current developments approaches nanoparticles, highlighting potential an effective alternative various therapeutic applications.
Язык: Английский
Процитировано
17
Nano Materials Science, Год журнала: 2024, Номер unknown
Опубликована: Март 1, 2024
The field of photocatalysis has witnessed a significant advancement in the development bioinspired and biomimetic photocatalysts for various biomedical applications, including drug delivery, tissue engineering, cancer therapy, bioimaging. Nature evolved efficient light-harvesting systems energy conversion mechanisms, which serve as benchmark researchers. However, reproducing such complexity harnessing it applications is daunting task. It requires comprehensive understanding underlying biological processes ability to replicate them synthetically. By utilizing light energy, these can trigger specific chemical reactions, leading targeted release, enhanced regeneration, precise imaging structures. In this context, addressing stability, long-term performance, scalability, cost-effectiveness materials crucial their widespread implementation applications. While challenges stability persist, advantages delivery personalized medicine make fascinating area research. purpose review provide analysis evaluation existing research, highlighting advancements, current challenges, advantages, limitations, future prospects biomedicine.
Язык: Английский
Процитировано
16
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Март 16, 2024
Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their translation requires a deep understanding complex interplay between nanotechnology MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative versatile microphysiological platform to replicate dynamics tissue microenvironment studying nanotechnology-biology interactions. This review first covers recent advances applications OoCs ability mimic biophysical biochemical stimuli encountered by tissues. Next, integrating into OoCs, cellular responses behaviors may be investigated precisely controlling manipulating nanoscale environment. Analysis disease mechanisms, particularly bone, joint, muscle degeneration, drug screening development personalized medicine greatly facilitated using OoCs. Finally, future challenges directions outlined field, including advanced sensing technologies, integration immune-active components, enhancement biomimetic functionality. By highlighting emerging this aims advance intricate nanotechnology-MSK biology interface its significance in management, therapeutic interventional strategies.
Язык: Английский
Процитировано
15
Chemical Society Reviews, Год журнала: 2024, Номер 53(15), С. 7657 - 7680
Опубликована: Янв. 1, 2024
Nanomaterials exhibit significant potential for stimulating immune responses, offering both local and systemic modulation across a variety of diseases. The lymphoid organs, such as the spleen lymph nodes, are home to various cells, including monocytes dendritic which contribute progression prevention/treatment Consequently, many nanomaterial formulations being rationally designed target these organs engage with specific cell types, thereby inducing therapeutic protective effects. In this review, we explore crucial cellular interactions processes involved in regulation highlight innovative nano-based immunomodulatory approaches. We outline essential considerations design an emphasis on their impact biological interactions, targeting capabilities, treatment efficacy. Through selected examples, illustrate strategic therapeutically active nanomaterials subsequent immunomodulation infection resistance, inflammation suppression, self-antigen tolerance, cancer immunotherapy. Additionally, address current challenges, discuss emerging topics, share our outlook future developments field.
Язык: Английский
Процитировано
12
MedComm – Biomaterials and Applications, Год журнала: 2022, Номер 1(2)
Опубликована: Сен. 1, 2022
Abstract Photothermal therapy (PTT) has been regarded as a promising strategy considering its advantages of high inherent specificity and lower invasive burden. Since the photothermal killing cells/bacteria showed different patterns death depending on varying temperature in PTT, change PTT is vital to cell/tissue response scientific research clinical application. On one hand, mild received substantial attention treatment cancer soft/hard tissue repair. other induced by capable antibacterial capacity, which better than conventional antibiotic with drug resistance. Herein, we summarize recent developments application temperature‐dependent biomaterials, mainly covering ranges 40–42°C, 43–50°C, over 50°C. We highlight biological mechanism latest progress diseases. Finally, conclude discussing challenges perspectives biomaterials addressing temperature‐orchestrated PTT. Given deep understanding interaction between biology, rationally designed sophisticated responsiveness will benefit outcomes personalized toward various
Язык: Английский
Процитировано
30
Materials Today, Год журнала: 2023, Номер 68, С. 125 - 147
Опубликована: Авг. 3, 2023
Язык: Английский
Процитировано
23
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, Год журнала: 2025, Номер 58(1)
Опубликована: Янв. 16, 2025
Over the past several decades, nanoparticles (NPs) have attracted considerable attention for anti-tumor treatment. However, exogenous NPs directly exposed to physiological environment are easily recognized as foreign substances and rapidly eliminated by immune system. Cell membrane camouflaging can provide "stealth" ability avoiding recognition elimination system, endows with diverse functionalities via inheriting functions of parent cells, representing a facile top-down approach multi-functionalization. In this review, we discuss unique biomedical tasks performed cell membrane-camouflaged tumor therapy in term circulation, targeting, immunity. addition intrinsic derived from camouflaging, introduce further improvements additional combinations novel technologies. Finally, highlight current challenges prospects these therapeutics that will contribute development.
Язык: Английский
Процитировано
1