Engineered exosomes from different sources for cancer-targeted therapy

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 15, 2023

Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort modified with surface decoration and internal molecules. After appropriate modification, engineered able to deliver antitumor drugs tumor sites efficiently precisely fewer treatment-related adverse effects. However, there still exist many challenges clinical translation exosomes. For instance, what sources modification strategies could endow most activity poorly understood. Additionally, how choose appropriately in different therapies another unresolved problem. In this review, we summarized characteristics exosomes, especially spatial temporal properties. concluded recent advances cancer fields, including sources, isolation technologies, strategies, labeling imaging methods Furthermore, applications were summarized, such photodynamic therapy, gene immunotherapy. Consequently, above provides researchers community latest ideas on exosome new direction drug development, prospective accelerate cancer-targeted therapy.

Язык: Английский

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Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Март 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Язык: Английский

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Organic Sonodynamic Materials for Combination Cancer Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(51)

Опубликована: Июнь 1, 2023

Sonodynamic therapy (SDT) is a promising non-invasive therapeutic modality to treat deep-seated tumors owing the good tissue penetration ability and spatiotemporal controllability of ultrasound (US); however, low sonodynamic activity potential side effects greatly limit its clinical translation. Cancer immunotherapy that leverages immune system fight against cancer has great synergize with SDT for treatment high efficiency safety. In this review, convergence exert their merits break through limitations combination sono-immunotherapy are discussed. The focus on development construction organic materials immunotherapeutic efficiency. These not only induce immunogenic cell death improve tumor immunogenicity via but also activate antitumor immunity immuno-oncology drug-mediated pathway modulation. various drugs sonosensitizers categorized discussed along prospects challenges

Язык: Английский

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Melatonin Engineering M2 Macrophage‐Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy

Advanced Science, Год журнала: 2023, Номер 10(27)

Опубликована: Июль 14, 2023

Periodontitis is a chronic infectious disease caused by bacterial irritation. As an essential component of the host immunity, macrophages are highly plastic and play crucial role in inflammatory response. An appropriate timely transition from proinflammatory (M1) to anti-inflammatory (M2) indispensable for treating periodontitis. M2 macrophage-derived exosomes (M2-exos) can actively target sites modulate immune microenvironments, M2-exos effectively treat Excessive endoplasmic reticulum stress (ER stress) unfolded protein response (UPR) destructive pathological characteristics during periodontal bone loss. Although melatonin has antioxidant effects, studies focusing on ER modulation remain limited. This study fabricates engineered loading with (Mel@M2-exos) result, drive macrophage reprogramming M1 type, which resolves inflammation accelerated healing. Melatonin released Mel@M2-exos rescues osteogenic cementogenic differentiation capacity human ligament cells (hPDLCs) reducing excessive UPR. Injectable gelatin methacryloyl (GelMA) hydrogels sustained-release accelerate regeneration rats ligation-induced Taken together, engineering promising candidates tissue regeneration.

Язык: Английский

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Stimuli responsive nanosonosensitizers for sonodynamic therapy

Journal of Controlled Release, Год журнала: 2023, Номер 361, С. 547 - 567

Опубликована: Авг. 15, 2023

Язык: Английский

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Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

Theranostics, Год журнала: 2023, Номер 13(6), С. 1974 - 2014

Опубликована: Янв. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Язык: Английский

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Extracellular Vesicles‐Derived Hybrid Nanoplatforms for Amplified CD47 Blockade‐Based Cancer Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(35)

Опубликована: Июнь 29, 2023

Immunomodulation of tumor-associated macrophages (TAMs) into tumor-inhibiting M1-like phenotype is a promising but challenging strategy. Cleverly, tumor cells overexpress CD47, "don't eat me" signal that ligates with the regulatory protein alpha (SIRPα) on to escape phagocytosis. Thus, effective re-education TAMs "eat type and blocking CD47-SIRPα signaling play pivotal roles in immunotherapy. Herein, it reported hybrid nanovesicles (hEL-RS17) derived from extracellular vesicles M1 decorated RS17 peptide, an antitumor peptide specifically binds CD47 blocks signaling, can actively target remodel TAM phenotypes. Consequently, more infiltrate tissue phagocytize due blockade. By further co-encapsulating chemotherapeutic agent shikonin, photosensitizer IR820, immunomodulator polymetformin hEL-RS17, enhanced effect obtained combinational treatment modality close synergy among each component. Upon laser irradiation, designed SPI@hEL-RS17 nanoparticles exert potent efficacy against both 4T1 breast B16F10 melanoma models, which not only suppresses primary growth also inhibits lung metastasis prevents recurrence, exhibiting great potential boosting blockade-based

Язык: Английский

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M2 Macrophage Hybrid Membrane‐Camouflaged Targeted Biomimetic Nanosomes to Reprogram Inflammatory Microenvironment for Enhanced Enzyme‐Thermo‐Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(39)

Опубликована: Июнь 20, 2023

Excessive inflammatory reactions caused by uric acid deposition are the key factor leading to gout. However, clinical medications cannot simultaneously remove and eliminate inflammation. An M2 macrophage-erythrocyte hybrid membrane-camouflaged biomimetic nanosized liposome (USM[H]L) is engineered deliver targeted self-cascading bienzymes immunomodulators reprogram microenvironment in gouty rats. The cell-membrane-coating endow nanosomes with good immune escape lysosomal achieve long circulation time intracellular retention times. After being uptaken cells, synergistic enzyme-thermo-immunotherapies achieved: uricase nanozyme degraded hydrogen peroxide, respectively; improved catalytic abilities of each other; produced photothermal effects; methotrexate has immunomodulatory anti-inflammatory effects. levels markedly decrease, ankle swelling claw curling effectively alleviated. cytokines ROS while cytokine increase. Proinflammatory M1 macrophages reprogrammed phenotype. Notably, IgG IgM USM[H]L-treated rats decrease substantially, uricase-treated show high immunogenicity. Proteomic analysis that there 898 downregulated 725 upregulated differentially expressed proteins protein-protein interaction network indicates signaling pathways include spliceosome, ribosome, purine metabolism, etc.

Язык: Английский

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Augmenting Immunogenic Cell Death and Alleviating Myeloid‐Derived Suppressor Cells by Sono‐Activatable Semiconducting Polymer Nanopartners for Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(33)

Опубликована: Май 11, 2023

Inducing immunogenic cell death (ICD) by sonodynamic therapy (SDT) is promising for cancer immunotherapy, which however inefficient due to oxygen depletion that compromises SDT effect and mediates recruitment of immunosuppressive myeloid-derived suppressor cells (MDSCs). The fabrication sono-activatable semiconducting polymer nanopartners (SPNTi ) simultaneously augment ICD alleviate MDSCs immunotherapy reported. A polymer, hydrophobic hypoxia-responsive tirapazamine (TPZ)-conjugate, MDSC-targeting drug (ibrutinib) are encapsulated inside such SPNTi with surface shell a singlet (1 O2 )-cleavable amphiphilic polymer. TPZ ibrutinib serve as partners enlarge immunotherapeutic effect. Upon sono-activation, generate 1 break -cleavable polymers in situ liberations TPZ-conjugate tumor sites, consumed create severe hypoxic microenvironment, which, activated augmenting action, while alleviates promoting antitumor immunological In bilateral mouse model, -mediated results growth restraints primary distant tumors noteworthy precaution metastases. This study thus provides strategy high precision safety via overcoming post-treatment hypoxia targeting MDSCs.

Язык: Английский

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Engineered Living Materials for Advanced Diseases Therapy

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Июль 12, 2023

Abstract Natural living materials serving as biotherapeutics exhibit great potential for treating various diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this review, the recent developments in engineered materials, including mammalian cells, bacteria, viruses, fungi, microalgae, plants, active derivatives that are used summarized. Further, future perspectives challenges of such material‐based discussed provide considerations advances biomedical applications.

Язык: Английский

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