Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 28, 2025
The
incidence
and
mortality
rates
of
liver
cancer
in
China
remain
elevated.
Although
early-stage
is
amenable
to
surgical
resection,
a
significant
proportion
patients
are
diagnosed
at
advanced
stages.
Currently,
addition
resection
for
hepatocellular
carcinoma,
the
primary
treatment
modalities
predominantly
include
chemotherapy.
widespread
use
chemotherapy,
which
non-selectively
targets
both
malignant
healthy
cells,
often
results
substantial
immunosuppression.
Simultaneously,
accumulation
chemotherapeutic
agents
can
readily
induce
drug
resistance
upon
reaching
physiological
threshold,
thereby
diminishing
efficacy
these
treatments.
Besides
there
exist
targeted
therapy,
immunotherapy
other
therapeutic
approaches.
Nevertheless,
development
remains
an
inevitable
challenge.
To
address
challenges,
we
turn
nanomedicine,
emerging
widely
utilized
discipline
that
significantly
influences
medical
imaging,
antimicrobial
strategies,
delivery
systems,
related
areas.
Stable
safe
nanomaterials
serve
as
effective
carriers
delivering
anticancer
drugs.
They
enhance
precision
targeting,
improve
bioavailability,
minimize
damage
cells.
This
review
focuses
on
common
nanomaterial
used
carcinoma
(HCC)
over
past
five
years.
following
summary
three
drugs:
Sorafenib,
Gefitinib,
lenvatinib.
Each
employs
distinct
result
varying
levels
release
rates,
efficacy.
Molecules,
Год журнала:
2023,
Номер
28(18), С. 6624 - 6624
Опубликована: Сен. 14, 2023
Knowing
the
beneficial
aspects
of
nanomedicine,
scientists
are
trying
to
harness
applications
nanotechnology
in
diagnosis,
treatment,
and
prevention
diseases.
There
also
potential
uses
designing
medical
tools
processes
for
new
generation
scientists.
The
main
objective
conducting
this
research
review
is
gather
widespread
nanomedicine
under
one
heading
highlight
standard
practices
field.
Comprehensive
has
been
conducted
incorporate
latest
data
related
medicine
therapeutics
derived
from
acknowledged
scientific
platforms.
Nanotechnology
used
conduct
sensitive
procedures.
showing
successful
fields
diagnostics,
disease
regenerative
medicine,
gene
therapy,
dentistry,
oncology,
aesthetics
industry,
drug
delivery,
therapeutics.
A
thorough
association
cooperation
between
physicians,
clinicians,
researchers,
technologies
will
bring
forward
a
future
where
there
more
calculated,
outlined,
technically
programed
field
nanomedicine.
Advances
being
made
overcome
challenges
associated
with
application
due
pathophysiological
basis
This
highlights
multipronged
how
proving
health
industry.
need
minimize
health,
environmental,
ethical
concerns
linked
nanotechnology.
ACS Nano,
Год журнала:
2024,
Номер
18(15), С. 10542 - 10556
Опубликована: Апрель 1, 2024
Immunotherapy
has
emerged
as
a
potential
approach
for
breast
cancer
treatment.
However,
the
rigid
stromal
microenvironment
and
low
immunogenicity
of
tumors
strongly
reduce
sensitivity
to
immunotherapy.
To
sensitize
patients
immunotherapy,
hyaluronic
acid-modified
zinc
peroxide–iron
nanocomposites
(Fe-ZnO2@HA,
abbreviated
FZOH)
were
synthesized
remodel
increase
tumor
immunogenicity.
The
constructed
FZOH
spontaneously
generated
highly
oxidative
hydroxyl
radicals
(·OH)
that
degrade
acid
(HA)
in
extracellular
matrix
(ECM),
thereby
reshaping
enhancing
blood
perfusion,
drug
penetration,
immune
cell
infiltration.
Furthermore,
not
only
triggers
pyroptosis
through
activation
caspase-1/GSDMD-dependent
pathway
but
also
induces
ferroptosis
various
mechanisms,
including
increasing
levels
Fe2+
intracellular
iron
pool,
downregulating
expression
FPN1
inhibit
efflux,
activating
p53
signaling
cause
failure
SLC7A11-GSH-GPX4
axis.
Upon
treatment
with
FZOH,
4T1
cells
undergo
both
pyroptosis,
exhibiting
strong
immunogenic
response.
remodeling
response
induced
by
collectively
compensate
limitations
immunotherapy
significantly
enhance
antitumor
checkpoint
inhibitor
αPD-1.
This
study
proposes
perspective
therapy
cancer.
Tumor
microenvironment
(TME)-induced
nanocatalytic
therapy
is
a
promising
strategy
for
cancer
treatment,
but
the
low
catalytic
efficiency
limits
its
therapeutic
efficacy.
Single-atom
catalysts
(SACs)
are
new
type
of
nanozyme
with
incredible
efficiency.
Here,
single-atom
manganese
(Mn)-N/C
constructed.
Mn-N/C
catalyzes
conversion
cellular
H
Abstract
For
tumor
treatment,
the
ultimate
goal
in
therapy
is
to
eliminate
primary
tumor,
manage
potential
metastases,
and
trigger
an
antitumor
immune
response,
resulting
complete
clearance
of
all
malignant
cells.
Tumor
microenvironment
(TME)
refers
local
biological
environment
solid
tumors
has
increasingly
become
attractive
target
for
cancer
therapy.
Neutrophils
within
TME
gastric
(GC)
spontaneously
undergo
ferroptosis,
this
process
releases
oxidized
lipids
that
limit
T
cell
activity.
Enhanced
photodynamic
(PDT)
mediated
by
di‐iodinated
IR780
(Icy7)
significantly
increases
production
reactive
oxygen
species
(ROS).
Meanwhile,
neutrophil
ferroptosis
can
be
triggered
increased
ROS
generation
TME.
In
study,
a
liposome
encapsulating
both
inhibitor
Liproxstatin‐1
modified
photosensitizer
Icy7,
denoted
LLI,
inhibits
growth
GC.
LLI
internalizes
into
MFC
cells
generate
causing
immunogenic
death
(ICD).
Simultaneously,
liposome‐deliver
effectively
neutrophils.
LLI‐based
PDT
neutrophil‐targeting
immunotherapy
synergistically
boost
anti‐PD‐1
treatment
elicit
potent
systemic
response
with
abscopal
effects.
conclusion,
holds
great
GC
immunotherapy.
Chemical Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.
RSC Advances,
Год журнала:
2024,
Номер
14(15), С. 10608 - 10637
Опубликована: Янв. 1, 2024
This
review
summarized
the
function
of
cancer
cell
membranes
and
comprehensively
discussed
preparation
membrane-coated
nanoparticles
(CCM-NPs)
their
application
in
anti-tumor
therapy.
The
graphical
abstract
figure
was
drawn
by
Figdraw
(https://www.figdraw.com).
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(40)
Опубликована: Июль 3, 2024
Abstract
Sonodynamic
therapy
(SDT),
as
a
promising
non‐invasive
therapeutic
modality
combining
ultrasound
(US)
and
sonosensitizers
to
produce
cytotoxic
reactive
oxygen
species
(ROS)
for
treating
deep‐seated
tumors,
has
received
increasing
attention
in
recent
years.
Porphyrins
are
multifunctional
organic
materials,
which
can
be
excited
both
by
light
US
ROS
possess
various
fascinating
features,
including
controllable
synthetic
processes,
excellent
biodegradability,
low
cytotoxicity
without
or
US.
Nevertheless,
their
poor
water
solubility,
skin‐photosensitive
toxicity,
insufficient
target
specificity
hinder
clinical
applications
sonosensitizer.
Although
the
issue
may
improved
using
nanoparticle
carriers,
SDT
efficacy
enhanced
with
other
modalities,
such
combination
makes
it
more
confusing
about
true
mechanism
of
SDT.
This
review
will
focus
on
following
points:
1)
Why
porphyrin‐based
considered
most
sonosensitizer
SDT?
2)
Recent
progress
development
sonosensitizers.
3)
What
new
insight
been
gained
years?
4)
The
trend
designing
efficient
existing
challenges.
Finally,
future
perspective
practical
based
discussed.
