The
enzymatic
activity
of
atomically
precise
metal
nanoclusters
has
recently
been
recognized;
however,
the
number
nanoclusterzymes
is
very
small.
Besides,
applications
nanoclusterzyme
wait
to
be
explored.
Herein,
a
novel
synthesized
and
its
structure
majorly
resolved
by
single-crystal
X-ray
diffraction
mass
spectrometry,
which
reveal
that
nanocluster
consists
an
Au13
icosahedron
capped
exterior
shell
including
four
I,
three
Dppp
(1,3-bis(diphenylphosphino)
propane)
ligands,
rarely
reported
Dppp-Au-Dppp
handle
staple,
contributes
lot
enzyme
[Au14
(Dppp)5
I4
]2+
nanocluster.
as-obtained
can
catalyze
oxygen
O2•-
under
visible
light
irradiation
with
specific
up
0.182
U·mg-1
lead
blue
color
3,3',5,5'-tetramethylbenzidine
(TMB)
in
both
solution
solid
states.
With
addition
acetylcholinesterase
(AChE),
(Au14
+
TMB)
system
disappears
due
inhibition,
but
further
organophosphorus
pesticides
(OPs)
into
above
mixture
restore
recover
color.
Based
on
turn-off
on,
various
nanoclusterzyme-containing
systems
are
used
colorimetrically
sense
AChE
OPs
detection
limits
reaching
0.04
mU·mL-1
0.02
ng·mL-1
,
respectively.
ACS Nano,
Год журнала:
2023,
Номер
17(8), С. 7837 - 7846
Опубликована: Апрель 6, 2023
Atomically
precise
gold
clusters
play
an
important
role
in
the
development
of
high-Z-element-based
radiosensitizers,
due
to
their
intriguing
structural
diversity
and
advantages
correlating
structures
properties.
However,
synthesis
with
both
water-solubility
single-crystal
structure
remains
a
challenge.
In
this
study,
atomically
Au25(S-TPP)18
(TPP-SNa
=
sodium
3-(triphenylphosphonio)propane-1-thiolate
bromide)
showing
mitochondria-targeting
ability
were
obtained
via
ligand
design
for
enhanced
radioimmunotherapy.
Compared
Au25(SG)18
(SG
glutathione),
exhibited
higher
radiosensitization
efficiency
its
ability,
ROS
production
capacity,
obvious
inhibition
upon
thioredoxin
reductase
(TrxR).
addition,
radiotherapy-triggered
abscopal
effect
combination
checkpoint
blockade
displayed
effective
growth
distant
tumors.
This
work
reveals
ligand-regulated
organelle
targeting
metal
by
which
feasible
strategies
promote
application
theranostics
could
be
realized.
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(25), С. 13514 - 13519
Опубликована: Июнь 12, 2023
Luminescent
metal–organic
cages
are
of
great
interest
in
contemporary
research;
however,
their
designed
synthesis
remains
challenging.
Here,
we
created
metal-cluster-derived
spacers,
where
emissive
C3-symmetric
Cu4
clusters
have
three
arms
modified
by
benzene
alkynyl
ligands,
which
terminally
functionalized
extensile
−COOH
and
15-crown-5-ether
groups
with
directional
coordination
ability.
Through
vertex
orientation,
−COOH-functionalized
cluster-based
spacers
coassembled
paddle-wheel
Cu(I)xZn(II)2-x(COO)3
nodes
3+3
mode,
generating
an
cubic
cage,
subsequently
gave
another
distorted
cage
synthetic
modification
on
the
nodes.
face
15-crown-5-ether-containing
capturing
K+
ions
3+2
mode
produced
octahedral
whose
empty
phase
showed
dual
emission
peaks,
leading
to
diverse
stimuli-responsive
photoluminescence.
This
work
provides
new
design
strategies
for
integration
based
metal
materials
as
well
prototypes
luminescent
metal-cluster
important
sensing
applications.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 5, 2024
Abstract
Background
Radiotherapy
is
one
of
the
mainstays
cancer
therapy
and
has
been
used
for
treating
65–75%
patients
with
solid
tumors.
However,
radiotherapy
tumors
two
limitations:
high-dose
X-rays
damage
adjacent
normal
tissue
tumor
metastases
cannot
be
prevented.
Results
Therefore,
to
overcome
limitations
radiotherapy,
a
multifunctional
core–shell
R837/BMS@Au8
nanoparticles
as
novel
radiosensitizer
were
fabricated
by
assembling
Au
8
NCs
on
surface
bifunctional
nanoimmunomodulator
R837/BMS
nanocore
using
nanoprecipitation
followed
electrostatic
assembly.
Formed
NP
composed
R837,
BMS-1,
clusters.
NC
can
enhance
X-ray
absorption
at
site
reduce
dose
releases
large
number
tumor-associated
antigens
under
irradiation.
With
help
immune
adjuvant
dendritic
cells
effectively
process
present
activate
effector
T
cells,
meanwhile,
small-molecule
PD-L1
inhibitor
BMS-1
block
PD-1/PD-L1
pathway
reactivate
cytotoxic
lymphocyte,
resulting
in
strong
systemic
antitumor
response
that
beneficial
limiting
metastasis.
According
vivo
vitro
experiments,
radioimmunotherapy
based
increase
calreticulin
expression
reactive
oxygen
species
generation,
DNA
breakage
decrease
colony
formation.
The
results
revealed
distant
78.2%
inhibited
depending
primary
use
NPs
realizes
low-dose
combined
immunotherapy
against
advanced
cancer.
Conclusion
In
conclusion,
metastasis
1
Gy,
providing
an
efective
strategy
construction
nanosystems
radiosensitizing
function.
Advanced Functional Materials,
Год журнала:
2022,
Номер
33(2)
Опубликована: Ноя. 4, 2022
Abstract
Effective
therapy
of
infection
impaired
tissue
defects
has
long
been
an
important
but
challenging
topic,
and
alternative
antibiotic‐free
solutions
are
greatly
demanded
to
tackle
bacterial
infections
promote
repair.
Herein,
the
use
supercharged
gold
nanoclusters
(AuNCs)
with
enhanced
enzyme
mimic
activity
as
novel
interface
modulator
bioactive
glass
nanoparticles
(BGN)
for
infected
wound
treatment
is
reported.
The
AuNCs
exhibit
extraordinary
affinity
toward
BGN,
leading
robust
immobilization
on
BGN
(BGN‐AuNCs).
Functional
endow
superior
peroxidase‐like
catalytic
antibacterial
action,
which
can
kill
bacteria
a
concentration
down
75
µg
mL
−1
within
6
h
due
production
highly
toxic
·OH.
Moreover,
expression
level
COL‐1,
TGF‐β,
FGF‐2
in
fibroblasts
actively
up‐regulated
2.9,
3.1,
1.6
times
higher
than
that
control
group
positive
effect
BGN‐AuNCs
cell
proliferation.
Meanwhile,
intrinsic
photoluminescent
property
enables
direct
visualization
at
both
vitro
vivo
levels
potentially
bioimaging‐guided
therapy.
Further
results
demonstrate
hold
enormous
promise
infectious
disease
pro‐regeneration,
proposed
engineering
strategy
attractive
developing
advanced
functional
nanomedicines.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Янв. 25, 2023
Abstract
Background
Combined
therapy
based
on
the
effects
of
cascade
reactions
nanoplatforms
to
combat
specific
solid
tumor
microenvironments
is
considered
a
cancer
treatment
strategy
with
transformative
clinical
value.
Unfortunately,
an
insufficient
O
2
supply
and
lack
visual
indication
hinder
further
applications
most
for
therapy.
Results
A
visualizable
nanoplatform
liposome
nanoparticles
loaded
GOD,
H(Gd),
PFP
grafted
peptide
tLyP-1,
named
tLyP-1
H(Gd)-GOD@PFP,
was
constructed.
The
double-domain
used
specifically
target
penetrate
cells;
then,
US
imaging,
starvation
sonodynamic
(SDT)
were
then
achieved
by
ultrasound
(US)-activated
cavitation
effect
under
guidance
MR/PA
imaging.
GOD
not
only
deprived
glucose
but
also
produced
H
,
which
in
coordination
1
enable
SDT
achieve
synergistic
therapeutic
effect.
Moreover,
enhanced
from
low-intensity
focused
(LIFU)-accelerated
redox
GOD.
present
study
demonstrated
that
could
generate
3.3-fold
increase
ROS,
produce
1.5-fold
maximum
rate
2.3-fold
vitro
significant
inhibition
vivo.
Conclusion
We
tumor-penetrating
ability
can
be
unlocked
overcome
current
problems
improving
controllability
supply,
ultimately
synergistically
