Опубликована: Янв. 1, 2024
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(23)
Опубликована: Апрель 3, 2024
Abstract Cuproptosis is an emerging cell death pathway that depends on the intracellular Cu ions. Elesclomol (ES) as efficient ionophore can specifically transport into mitochondria and trigger cuproptosis. However, ES be rapidly removed metabolized during intravenous administration, leading to a short half‐life limited tumor accumulation, which hampers its clinical application. Here, study develops reactive oxygen species (ROS)‐responsive polymer (PCP) based cinnamaldehyde (CA) polyethylene glycol (PEG) encapsulate ES‐Cu compound (EC), forming ECPCP. ECPCP significantly prolongs systemic circulation of EC enhances accumulation. After cellular internalization, PCP coating stimulatingly dissociates exposing high‐level ROS, releases Cu, thereby triggering via Meanwhile, 2+ ‐stimulated Fenton‐like reaction together with CA‐stimulated ROS production simultaneously breaks redox homeostasis, compensates for insufficient oxidative stress treated alone, in turn inducing immunogenic cells, achieving simultaneous cuproptosis immunotherapy. Furthermore, excessive accelerates stimuli‐dissociation ECPCP, positive feedback therapy loop against self‐alleviation. Therefore, nanoplatform immunotherapy improves dual antitumor mechanism provides potential optimization
Язык: Английский
Процитировано
48
Nano Today, Год журнала: 2024, Номер 55, С. 102166 - 102166
Опубликована: Янв. 22, 2024
Язык: Английский
Процитировано
16
Nano Today, Год журнала: 2024, Номер 57, С. 102371 - 102371
Опубликована: Июнь 24, 2024
Язык: Английский
Процитировано
11
Small, Год журнала: 2024, Номер 20(28)
Опубликована: Фев. 11, 2024
Abstract In order to avoid the time‐consuming and laborious identification of tumor‐specific antigens (TSAs) during traditional vaccine fabrication process, a versatile photodynamic therapy (PDT)‐based method is developed construct whole‐tumor antigen tumor (TV) from surgically resected tissues for personalized immunotherapy. Mucoadhesive nanoparticles containing small‐molecular photosensitizer are fabricated directly co‐incubated with suspended cells obtained after cytoreduction surgery. After irradiation 405 nm laser, potent immunogenic cell death cancer could be induced. Along release TSAs, as‐prepared TV activate safe robust immune responses, leading efficient suppression postsurgery recurrence metastasis. The cannot only applied alone through various administration routes but also synergize immunoadjuvant, chemotherapeutics, checkpoint blockers exert more responses. This work provides an alternative way promote clinical translation PDT, which generally restricted by limited penetration light. Moreover, strategy facilitates application whole‐cell vaccines.
Язык: Английский
Процитировано
6
Small Methods, Год журнала: 2023, Номер 8(1)
Опубликована: Окт. 17, 2023
Abstract Despite the tremendous progress in cancer treatment recent decades, cancers often become resistant due to multiple mechanisms, such as intrinsic or acquired multidrug resistance, which leads unsatisfactory effects accompanying metastasis and recurrence, ultimately failure. With a deeper understanding of molecular mechanisms tumors, researchers have realized that designs targeting tumor resistance would be promising strategy break therapeutic deadlock. Nanodelivery systems excellent physicochemical properties, including highly efficient tissue‐specific delivery, substantial specific surface area, controllable chemistry, endow nanodelivery with capabilities precise targeting, deep penetration, responsive drug release, codelivery, multimodal synergy, are currently widely used biomedical researches bring new dawn for overcoming resistance. Based on this review summarizes research improve efficacy years offers prospects challenges application
Язык: Английский
Процитировано
10
Regenerative Biomaterials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
In this article, we fabricated nanomedicines with mitochondrial targeting function and autophagy inhibitor for enhancing cancer photothermal-chemotherapy. The nanoparticles were gold (AuNPs) as cores amphiphilic dextran (3-carboxypropyl) triphenyl phosphorus bromide β-cyclodextrin (β-CD) modification (TPP-DCD) shells; the chemotherapeutic doxorubicin (DOX) chloroquine (CQ) encapsulated in nanoparticles. TPP-DCD was synthesized via immobilization of 2-aminoethanethiol modified β-CD triphenylphosphonium on to receive coordination interaction AuNPs mitochondria targeting. size, morphology properties Au@DOX/CQ@TPP-DCD studied. efficiently targeted cellular produce reactive oxygen species photothermal effect under NIR irradiation. released DOX CQ could not only kill tumor cells directly, but also inhibit enhance therapeutic effects. Both vitro vivo anticancer activities investigated detail. imaging demonstrated that exhibited efficient targeting, accumulation retention tumor-bearing mice. apoptosis suppression greatly accelerated addition 808 nm nanomedicine significant synergistic therapy, 75% tumors mice disappeared. nanoparticle is a promising therapy
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Developing nanomedicines with simultaneous diagnosis and treatment functions is a promising therapeutic strategy for cancer therapy. Herein, multifunctional manganese oxide-mesoporous carbon nanoparticles (MnOx-MCN NPs) were designed magnetic resonance imaging (MRI)-guided chemotherapy, photothermal therapy (PTT), chemodynamic (CDT). The excellent conversion efficiency (44.2%) outstanding fenton-like catalytic activity endowed MnOx-MCN NPs PTT/CDT synergistic Furthermore, their unique mesoporous structure, can also act as drug delivery carrier encapsulating chemotherapy agent doxorubicin (DOX). mild acid tumor microenvironment (TME) near-infrared (NIR) heat induced the release of DOX. In addition, NIR laser enhanced CDT NPs, thus generating chemotherapy/PTT/CDT effect. Extracellular experiments demonstrated that generated by irradiation could encourage generation •OH. More importantly, displayed superior anticancer both in vitro vivo. Such elaborately synthesized nanomaterial provides paradigm design other multifunction nanoagents.
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Immunotherapy is a critical modality in cancer treatment with diverse activation pathways. In recent years, the stimulator of interferon genes (STING) signaling pathway has exhibited significant potential tumor immunotherapy. This exerts notable antitumor effects by activating innate and adaptive immunity regulating immune microenvironment. Various metal ions have been identified as effective activators STING and, through design synthesis nanodelivery platforms, applied immunotherapy well combination therapies, such chemotherapy, chemodynamic therapy, photodynamic vaccines. Metal nanomaterials showcase unique advantages immunotherapy; however, there are still aspects that require optimization. review systematically examines existing metal-based nanomaterials, elaborates on mechanisms which different activate pathway, discusses their application models therapies. We also provide comparative analysis over other methods. Our exploration highlights broad prospects treatment, offering new insights directions for advancement
Язык: Английский
Процитировано
0
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Tumor immunotherapy has shown considerable therapeutic potential, especially when combined with chemotherapy. In this study, we developed a multifunctional nanoplatform GNPs-DOX/R848 that and chemotherapy for the treatment of melanoma, in which gelatin nanoparticles (GNPs) were loaded immunomodulatory agent resiquimod (R848) drug doxorubicin (DOX). GNPs possessed inherent properties; R848, they induced more pronounced polarization M1-like macrophages by activating NF-κB signaling pathway, thereby reversing immunosuppressive tumor microenvironment. Meanwhile, effectively delivered R848 DOX to cells, promoting stronger effects drugs, strongly immunogenic cell death triggered DOX, leading infiltration T cells into tissue. The melanoma demonstrated significantly reduced volume, enhanced chemotherapy, providing new approach cancer
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(17), С. 4162 - 4171
Опубликована: Янв. 1, 2024
A defect-rich hollow Schottky heterojunction sonosensitizer, constructed by defect engineering and noble metal enrichment, exhibits an amplified treatment effect for sonodynamic therapy due to the inhibition of electron–hole pair recombination.
Язык: Английский
Процитировано
2