Nanoclusterzyme for Dual Colorimetric Sensings: A Case Study on [Au14(Dppp)5I4]2+ DOI Open Access

Hongliang Zhao,

Qing You,

Wanli Zhu

и другие.

Small, Год журнала: 2023, Номер 19(30)

Опубликована: Апрель 14, 2023

The enzymatic activity of atomically precise metal nanoclusters has recently been recognized; however, the number nanoclusterzymes is very small. Besides, applications nanoclusterzyme wait to be explored. Herein, a novel synthesized and its structure majorly resolved by single-crystal X-ray diffraction mass spectrometry, which reveal that nanocluster consists an Au13 icosahedron capped exterior shell including four I, three Dppp (1,3-bis(diphenylphosphino) propane) ligands, rarely reported Dppp-Au-Dppp handle staple, contributes lot enzyme [Au14 (Dppp)5 I4 ]2+ nanocluster. as-obtained can catalyze oxygen O2•- under visible light irradiation with specific up 0.182 U·mg-1 lead blue color 3,3',5,5'-tetramethylbenzidine (TMB) in both solution solid states. With addition acetylcholinesterase (AChE), (Au14 + TMB) system disappears due inhibition, but further organophosphorus pesticides (OPs) into above mixture restore recover color. Based on turn-off on, various nanoclusterzyme-containing systems are used colorimetrically sense AChE OPs detection limits reaching 0.04 mU·mL-1 0.02 ng·mL-1 , respectively.

Язык: Английский

Multiscale Bioresponses of Metal Nanoclusters DOI
Yujia Shi, Zhennan Wu, Manlin Qi

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(13)

Опубликована: Дек. 25, 2023

Abstract Metal nanoclusters (NCs) are well‐recognized novel nano‐agents that hold great promise for applications in nanomedicine because of their ultrafine size, low toxicity, and high renal clearance. As foreign substances, however, an in‐depth understanding the bioresponses to metal NCs is necessary but still far from being realized. Herein, this review deployed summarize biofates at various biological levels, emphasizing multiscale molecular, cellular, organismal levels. In parts‐to‐whole schema, interactions between biomolecules discussed, presenting typical protein‐dictated nano–bio interfaces, hierarchical structures, vivo trajectories. Then, accumulation, internalization, metabolic evolution cellular environment as‐imparted theranostic functionalization demonstrated. The metabolism transportation processes subsequently distilled. Finally, ends with conclusions perspectives on outstanding issues NC‐mediated near future. This expected provide inspiration tailoring customization NC‐based meet practical requirements different sectors nanomedicine.

Язык: Английский

Процитировано

17
Biochemical hallmarks-targeting antineoplastic nanotherapeutics DOI Creative Commons
J. G. Han, He Dong, Tianyi Zhu

и другие.

Bioactive Materials, Год журнала: 2024, Номер 36, С. 427 - 454

Опубликована: Июнь 1, 2024

Tumor microenvironments (TMEs) have received increasing attention in recent years as they play pivotal roles tumorigenesis, progression, metastases, and resistance to the traditional modalities of cancer therapy like chemotherapy. With rapid development nanotechnology, effective antineoplastic nanotherapeutics targeting aberrant hallmarks TMEs been proposed. The appropriate design fabrication endow nanomedicines with abilities for active targeting, TMEs-responsiveness, optimization physicochemical properties tumors, thereby overcoming transport barriers significantly improving therapeutic benefits. This review begins origins characteristics discusses latest strategies modulating by focusing on regulation biochemical microenvironments, such tumor acidosis, hypoxia, dysregulated metabolism. Finally, this summarizes challenges smart anti-cancer TME modulation examines promising combination therapies treatments further clinical translation.

Язык: Английский

Процитировано

6
Atomically Precise Cu Nanoclusters: Recent Advances, Challenges, and Perspectives in Synthesis and Catalytic Applications DOI Creative Commons

Mengyao Chen,

Chengyu Guo, Lubing Qin

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 17(1)

Опубликована: Дек. 3, 2024

Abstract Atomically precise metal nanoclusters are an emerging type of nanomaterial which has diverse interfacial metal–ligand coordination motifs that can significantly affect their physicochemical properties and functionalities. Among that, Cu have been gaining continuous increasing research attentions, thanks to the low cost, diversified structures, superior catalytic performance for various reactions. In this review, we first summarize recent progress regarding synthetic methods atomically modes between several typical ligands then discuss applications these with some explicit examples explain atomical-level structure–performance relationship. Finally, current challenges future perspectives critical thoughts elaborated. We hope review not only provide a whole picture advances synthesis nanoclusters, but also points out visions in rapidly booming field.

Язык: Английский

Процитировано

6
Ultrasmall PtAu2 nanoclusters activate endogenous anti-inflammatory and anti-oxidative systems to prevent inflammatory osteolysis DOI Creative Commons
Xuzhuo Chen, Xiankun Cao,

Dasheng Zheng

и другие.

Theranostics, Год журнала: 2023, Номер 13(3), С. 1010 - 1027

Опубликована: Янв. 1, 2023

Rationale: Inflammatory osteolysis, characterized by abundant immune cell infiltration and osteoclast (OC) formation, is a common complication induced bacterial products and/or wear particles at the bone-prosthesis interface that severely reduces long-term stability after implantation.Molecular nanoclusters are ultrasmall with unique physicochemical biological properties have great potential as theranostic agents for treating inflammatory diseases.Methods: In this study, heterometallic PtAu2 sensitive nitric oxide-responsive phosphorescence turn-on characteristics strong binding interactions cysteine were designed, making them desirable candidates treatment of osteolysis.Results: clusters exhibited satisfactory biocompatibility cellular uptake behavior, potent antiinflammatory anti-OC activities in vitro.In addition, alleviated lipopolysaccharide-induced calvarial osteolysis vivo activated nuclear factor erythroid 2-related 2 (Nrf2) expression disrupting its association Kelch-like ECH-associated protein 1 (Keap1), thereby upregulating endogenous anti-inflammatory anti-oxidative products.Conclusion: Through rational design novel activate system, study provides new insights into development multifunctional molecular therapeutic other diseases.

Язык: Английский

Процитировано

13
Nanoclusterzyme for Dual Colorimetric Sensings: A Case Study on [Au14(Dppp)5I4]2+ DOI Open Access

Hongliang Zhao,

Qing You,

Wanli Zhu

и другие.

Small, Год журнала: 2023, Номер 19(30)

Опубликована: Апрель 14, 2023

The enzymatic activity of atomically precise metal nanoclusters has recently been recognized; however, the number nanoclusterzymes is very small. Besides, applications nanoclusterzyme wait to be explored. Herein, a novel synthesized and its structure majorly resolved by single-crystal X-ray diffraction mass spectrometry, which reveal that nanocluster consists an Au13 icosahedron capped exterior shell including four I, three Dppp (1,3-bis(diphenylphosphino) propane) ligands, rarely reported Dppp-Au-Dppp handle staple, contributes lot enzyme [Au14 (Dppp)5 I4 ]2+ nanocluster. as-obtained can catalyze oxygen O2•- under visible light irradiation with specific up 0.182 U·mg-1 lead blue color 3,3',5,5'-tetramethylbenzidine (TMB) in both solution solid states. With addition acetylcholinesterase (AChE), (Au14 + TMB) system disappears due inhibition, but further organophosphorus pesticides (OPs) into above mixture restore recover color. Based on turn-off on, various nanoclusterzyme-containing systems are used colorimetrically sense AChE OPs detection limits reaching 0.04 mU·mL-1 0.02 ng·mL-1 , respectively.

Язык: Английский

Процитировано

11