Nanozyme‐Engineered Bioglass through Supercharged Interface for Enhanced Anti‐Infection and Fibroblast Regulation

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(2)

Published: Nov. 4, 2022

Abstract Effective therapy of infection impaired tissue defects has long been an important but challenging topic, and alternative antibiotic‐free solutions are greatly demanded to tackle bacterial infections promote repair. Herein, the use supercharged gold nanoclusters (AuNCs) with enhanced enzyme mimic activity as novel interface modulator bioactive glass nanoparticles (BGN) for infected wound treatment is reported. The AuNCs exhibit extraordinary affinity toward BGN, leading robust immobilization on BGN (BGN‐AuNCs). Functional endow superior peroxidase‐like catalytic antibacterial action, which can kill bacteria a concentration down 75 µg mL −1 within 6 h due production highly toxic ·OH. Moreover, expression level COL‐1, TGF‐β, FGF‐2 in fibroblasts actively up‐regulated 2.9, 3.1, 1.6 times higher than that control group positive effect BGN‐AuNCs cell proliferation. Meanwhile, intrinsic photoluminescent property enables direct visualization at both vitro vivo levels potentially bioimaging‐guided therapy. Further results demonstrate hold enormous promise infectious disease pro‐regeneration, proposed engineering strategy attractive developing advanced functional nanomedicines.

Language: Английский

---

Multiscale Bioresponses of Metal Nanoclusters

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(13)

Published: Dec. 25, 2023

Abstract Metal nanoclusters (NCs) are well‐recognized novel nano‐agents that hold great promise for applications in nanomedicine because of their ultrafine size, low toxicity, and high renal clearance. As foreign substances, however, an in‐depth understanding the bioresponses to metal NCs is necessary but still far from being realized. Herein, this review deployed summarize biofates at various biological levels, emphasizing multiscale molecular, cellular, organismal levels. In parts‐to‐whole schema, interactions between biomolecules discussed, presenting typical protein‐dictated nano–bio interfaces, hierarchical structures, vivo trajectories. Then, accumulation, internalization, metabolic evolution cellular environment as‐imparted theranostic functionalization demonstrated. The metabolism transportation processes subsequently distilled. Finally, ends with conclusions perspectives on outstanding issues NC‐mediated near future. This expected provide inspiration tailoring customization NC‐based meet practical requirements different sectors nanomedicine.

Language: Английский

---

Ultrasmall PtAu₂ nanoclusters activate endogenous anti-inflammatory and anti-oxidative systems to prevent inflammatory osteolysis

Theranostics, Journal Year: 2023, Volume and Issue: 13(3), P. 1010 - 1027

Published: Jan. 1, 2023

Rationale: Inflammatory osteolysis, characterized by abundant immune cell infiltration and osteoclast (OC) formation, is a common complication induced bacterial products and/or wear particles at the bone-prosthesis interface that severely reduces long-term stability after implantation.Molecular nanoclusters are ultrasmall with unique physicochemical biological properties have great potential as theranostic agents for treating inflammatory diseases.Methods: In this study, heterometallic PtAu2 sensitive nitric oxide-responsive phosphorescence turn-on characteristics strong binding interactions cysteine were designed, making them desirable candidates treatment of osteolysis.Results: clusters exhibited satisfactory biocompatibility cellular uptake behavior, potent antiinflammatory anti-OC activities in vitro.In addition, alleviated lipopolysaccharide-induced calvarial osteolysis vivo activated nuclear factor erythroid 2-related 2 (Nrf2) expression disrupting its association Kelch-like ECH-associated protein 1 (Keap1), thereby upregulating endogenous anti-inflammatory anti-oxidative products.Conclusion: Through rational design novel activate system, study provides new insights into development multifunctional molecular therapeutic other diseases.

Language: Английский

---

Nanoclusterzyme for Dual Colorimetric Sensings: A Case Study on [Au₁₄(Dppp)₅I₄]²⁺

Small, Journal Year: 2023, Volume and Issue: 19(30)

Published: April 14, 2023

The enzymatic activity of atomically precise metal nanoclusters has recently been recognized; however, the number nanoclusterzymes is very small. Besides, applications nanoclusterzyme wait to be explored. Herein, a novel synthesized and its structure majorly resolved by single-crystal X-ray diffraction mass spectrometry, which reveal that nanocluster consists an Au13 icosahedron capped exterior shell including four I, three Dppp (1,3-bis(diphenylphosphino) propane) ligands, rarely reported Dppp-Au-Dppp handle staple, contributes lot enzyme [Au14 (Dppp)5 I4 ]2+ nanocluster. as-obtained can catalyze oxygen O2•- under visible light irradiation with specific up 0.182 U·mg-1 lead blue color 3,3',5,5'-tetramethylbenzidine (TMB) in both solution solid states. With addition acetylcholinesterase (AChE), (Au14 + TMB) system disappears due inhibition, but further organophosphorus pesticides (OPs) into above mixture restore recover color. Based on turn-off on, various nanoclusterzyme-containing systems are used colorimetrically sense AChE OPs detection limits reaching 0.04 mU·mL-1 0.02 ng·mL-1 , respectively.

Language: Английский

---

Cu₂Se-Based Thermoresponsive Multifunctional Nanomaterial Initiated by NIR-II Light for Cancer Therapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

---